Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
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HR (bts/min)<br />
30<br />
20<br />
halothane<br />
isoflurane<br />
<strong>de</strong>sflurane<br />
sevoflurane<br />
10<br />
0<br />
0.5 1 1.5 2 2.5 MAC<br />
Weiskopf Eger EI RB II et Anesthesiology al. Analg 75:517,1991 55:559,1981<br />
Prikkelgeleiding<br />
• halothane vermin<strong>de</strong>rt sino-atriale geleiding: atrioventriculair<br />
ritme<br />
• halothane sensitiseert myoard voor catecholamines:<br />
ritmestoornissen (VES)<br />
• enflurane: negatief lusotroop (diastolic function = ability to<br />
relax), junctioneel ritme frequent (daling HD)
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