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Farmacologie van de inhalatie-anesthetica

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Stages of inhalation anesthesia<br />

Halothane: hemodynamica<br />

• myocard<strong>de</strong>pressie met daling <strong>van</strong> het hart<strong>de</strong>biet<br />

• gering effect op perifeer vasculaire weerstand (SVR)<br />

• geen orthosympatische activatie; bij neonaten <strong>de</strong>pressie en<br />

parasympathisch overwicht<br />

• weinig Δ polsfrequentie, baroreceptor reflex on hypovolemia impaired<br />

• geen coronaire vasodilatatie<br />

• coronaire bloedflow daalt

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