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COSIG CONFERENCE BROCHURE.pdf - Drexel University College ...

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468<br />

Mental retardation<br />

For the psychiatrist who is managing medications, and is<br />

part of a team of other mental health professionals, when<br />

accepting a patient with FASD, they will very often ®nd<br />

themselves caring for an individual with chronic and<br />

persistent mental illness. The symptomatology and the<br />

response to medication may wax and wane over time as<br />

the individual grows and matures, passing physiologically<br />

into different phases of their life. In addition to<br />

concrete symptom relief, being able to support the<br />

patient and family through crisis is one of the most<br />

important and meaningful tools that psychiatrists and<br />

other mental health providers have at their disposal.<br />

Even if the treatment is not as effective as hoped,<br />

helping the family to avoid `burn-out', maintain hope<br />

and enthusiasm for the individual's welfare, and entering<br />

into a partnership with them to lead this individual to<br />

their best outcome, are all skills that are important to<br />

desperate parents [44].<br />

When approaching psychopharmacological treatment,<br />

the psychiatrist needs to be cognizant of common<br />

physical problems that can complicate one's ability to<br />

treat these individuals safely (cardiac problems, possibly<br />

lowered seizure threshold, optic nerve hypoplasia,<br />

auditory and vestibular problems) as well as atypical<br />

responses to commonly used medications. Approaching<br />

carefully as in the treatment of other organic brain<br />

syndromes is in order; especially in severely affected<br />

individuals.<br />

Conclusion<br />

Mental health treatment research is understood to be<br />

one of the most urgent areas in need of further<br />

development. Better psychopharmacological approaches,<br />

focused individual and group psychotherapy across a<br />

number of domains (behavioral, social and cognitive)<br />

need to be developed speci®cally for these individuals.<br />

Disability criteria need to be broadened in each region,<br />

to accommodate the recent neurodevelopmental data<br />

demonstrating severe disability across a spectrum of<br />

effects. Those with the full FAS criteria are just a small<br />

proportion of those experiencing severe limitations in<br />

functioning as a consequence of prenatal alcohol<br />

exposure. The rather large number of individuals with<br />

some alcohol-related disability, with and without dysmorphic<br />

features, or mental retardation leaves the mental<br />

health community worldwide with the great responsibility<br />

of identifying and providing life-enhancing support,<br />

understanding and treatment to this very needy<br />

population.<br />

Acknowledgements<br />

The author wishes to thank Cynthia Keysor, PhD and Elaine Tierney,<br />

MD for their assistance in preparing this manuscript.<br />

References and recommended reading<br />

Papers of particular interest, published within the annual period of review, have<br />

been highlighted as:<br />

. of special interest<br />

.. of outstanding interest<br />

1 Committee on Substance Abuse and Committee on Children with Disabilities.<br />

. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders.<br />

Pediatrics 2000; 106: no 2.<br />

This is a quick overview of prenatal alcohol exposure related disabilities.<br />

2 Hagaman RJ. Fetal alcohol syndrome in neurodevelopmental disorders ±<br />

diagnosis and treatment. Oxford <strong>University</strong> Press, New York; 1999. pp. 1±<br />

59.<br />

3 Streissguth AP. Fetal alcohol syndrome: A guide for families and communities.<br />

Brooks Publishing, Baltimore, Maryland; 1997.<br />

4 Streissguth AP, O'Malley K. Neuropsychiatric implications and long-term<br />

.. consequences of fetal alcohol spectrum disorders. Semin Clin Neuropsychiatry<br />

2000; 5:177±190.<br />

This very timely article explains that there is an urgent need for treatment research<br />

into the neuropsychiatric sequelae of FASD. The authors review the `secondary<br />

disabilities', that can arise from the disorder especially if not adequately identified<br />

early by the medical and mental health community.<br />

5 Lemoine P, Harouseau H, Borteryu JT, Menuet JC. Les enfants des parents<br />

alcooliques: anomalies observe es apropos de 127 cas. Ouest Medical 1968;<br />

21:476±482.<br />

6 Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early<br />

infancy. Lancet 1973; 2:999±1001.<br />

7 Jones KL, Smith D, Ulleland CN, Streissguth AP. Pattern of malformation in<br />

offspring of chronic alcoholic mothers. Lancet 1973; 1:1267±1271.<br />

8 Olson HC. Helping individuals with fetal alcohol syndrome and related<br />

conditions: a clinician's overview. Presented at the National FAS Conference.<br />

Atlanta, Georgia, 27±28 April 2001.<br />

9 Stratton, K. Howe, C. Battaglia, F. (editors) Fetal alcohol syndrome:<br />

Diagnosis, epidemiology, prevention and treatment. Institute of Medicine<br />

National Academy Press, Wash. DC; 1996; 4±5.<br />

10 Astley SJ, Clarren SK. A case definition and photographic screening tool for<br />

the facial phenotype of fetal alcohol syndrome. J Pediatr 1996; 129:33±41.<br />

11 Astley SJ, Clarren SK. Measuring the facial phenotype of individuals with<br />

. prenatal alcohol exposure: correlations with brain dysfunction. Alcohol and<br />

Alcoholism 2001; 36:147±159.<br />

This article describes a 4-Digit Diagnostic Code that quantifies and correlates the<br />

expression of the facial features of FAS and other alcohol related symptoms with<br />

structural brain abnormalities in alcohol exposed individuals.<br />

12 Sampson PD, Streissguth AP, Bookstein FL, Barr HM. Environmental health<br />

perspectives. On categorizations in analyses of alcohol teratogenesis.<br />

Environ Health Perspect 2000; 108 (Suppl. 3):421±428.<br />

13 Su B, Debelak KA, Tessmer LL, et al. Genetic influences in craniofacial<br />

. outcome in an avian model of prenatal alcohol exposure. Alcoholism, Clin Exp<br />

Res 2001; 25:60±69.<br />

This article demonstrates that influences on craniofacial development are<br />

multifactorial and that genetic influences may underlie the differences in facial<br />

dysmorphia in alcohol exposed chicks when dose and timing of exposure were<br />

held constant.<br />

14 Chaudhuri Joydeep D. Alcohol and the developing fetus ± A Review. Med Sci<br />

2000; 6:1031±1041.<br />

15 Menegola E, Broccia ML, Di Renzo F, Giavini E. Acetaldehyde in vitro exposure<br />

. and apoptosis: a possible mechanism of teratogenesis. Alcohol 2001; 23:35±<br />

39.<br />

Acetaldehyde is shown in this study to be as teratogenic as ethanol.<br />

16 Ikonomidou C, Bittigau P, Ishimaru J, et al. Ethanol±induced apoptotic neurodegeneration<br />

and fetal alcohol syndrome. Science 2000; 287:1056±1060.<br />

17 Bonthius DJ, Woodhouse J, Bonthius NE, et al. Reduced seizure threshold<br />

and hippocampal cell loss in rats exposed to alcohol during the brain growth<br />

spurt. Alcohol Clin Exp Res 2001; 25:70±82.<br />

18 Ponnappa BC, Rubin E. Modeling alcohol's effects on organs in animal models.<br />

. Alcohol Research Health 2000; 24:93±104.<br />

This review very clearly describes a number of possible neurobiological<br />

mechanisms underlying alcohol's toxic effects on a number of organ systems<br />

including the central nervous system.<br />

19 Miller MW. Effects of alcohol on the generation and migration of cerebral<br />

cortical neurons. Science 1986; 233:1308±1311.

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