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COSIG CONFERENCE BROCHURE.pdf - Drexel University College ...

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<strong>COSIG</strong> Co-Occurring Disorders Conference, Hershey PA, May 15-17, 2006<br />

Suspected Mechanisms Implicated in<br />

CNS Damage<br />

• Cell death modes(necrosis and apoptosis)<br />

• Free radical damage<br />

• Interference with growth factor functions<br />

• Adverse effects on astrocyte formation<br />

• Abnormal development of neurotransmitter system<br />

• Altered glucose transport and uptake<br />

• Abnormal cell adhesion molecules<br />

• Altered regulation of gene expression<br />

Cerebrum<br />

Corpus Callosum<br />

Change in brain size<br />

Cerebellum<br />

100<br />

95<br />

90<br />

85<br />

80<br />

75<br />

Cerebrum<br />

p < 0.010<br />

PEA<br />

Cerebellum<br />

***<br />

**<br />

FAS p < 0.001<br />

Mattson et al., 1994<br />

Cerebral Cortex<br />

Migration Problems<br />

• cerebral architecture is affected<br />

• changes in myelination.<br />

• neurons do not make their way to their<br />

proper location.<br />

• frontal lobes and parietal lobes can be<br />

heavily affected<br />

During embryonic development cells fail to<br />

migrate to their proper location<br />

Miller, 1986<br />

Blood vessel<br />

Neuron<br />

Cortical layer<br />

I<br />

II<br />

III<br />

IV<br />

V<br />

Neuronal Effects<br />

• neurogenesis<br />

• neuronal differentiation<br />

• neuronal migration<br />

• arborization<br />

• synaptogenesis<br />

VI<br />

Miller, 1986<br />

7

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