Incontinence Associated Dermatitis
Incontinence Associated Dermatitis
Incontinence Associated Dermatitis
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Moisture Barrier:<br />
Additional Factors<br />
Aquaglyceroporin AQP3 1<br />
– Membrane protein that forms water channels across<br />
cell facilitating transport of water, urea, glycerol<br />
within epidermis but preventing excessive loss via SC<br />
– Expressed from the granulosum to just below the SC<br />
Tight Membrane Junctions 2<br />
– Water gradient steepest at junction or stratum<br />
corneum and stratum granulosum<br />
– TMJ comprises transmembrane proteins that control<br />
skin permeability<br />
1. Verkman AS, Mitra American J Physiology Renal Phys 2000; 278: F13.<br />
2. Madara JL. Annual Review of Physiology 1998; 60: 143.
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