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Incontinence Associated Dermatitis

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Barrier Function: The Bricks<br />

Corneocytes (keratinocytes)<br />

– Anucleated cells filled with<br />

keratin & other molecules created<br />

by breakdown of filaggrin<br />

– Collectively referred to as natural<br />

moisturizing factor (NMF)<br />

– Surrounded by cornified<br />

envelope (corneodesmosomes(<br />

corneodesmosomes)<br />

that degrade as they move to<br />

surface of skin<br />

– 20% content is H 2 0<br />

Verdier-Sevrain<br />

S, Bonte F. J Cosmetic Dermatology 2007; 6:75.<br />

Gray M. American Journal of Clinical Dermatology 2010; 11(3): 201.<br />

Figure:<br />

http://www.bioskinregeneration.com/wrinkles/skin.j<br />

pg

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