AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
convulsion when ammonium sulfate was injected.<br />
Reliability: (2) valid with restrictions<br />
limited documentation, no further information on purity<br />
18-NOV-<strong>20</strong>03 (109)<br />
Type:<br />
Distribution<br />
Remark:<br />
In aqueous environments, such as the body the ammonium sulfate<br />
is completely dissociated into the ammonium (NH4+) and the<br />
sulfate (SO42-) ions. At physiological pH in aqueous media,<br />
the ammonium ion is in equilibrium with un-ionized ammonia,<br />
according to the following equation:<br />
NH4+ + H2O --- NH3 + H3O+<br />
The ammonium ion serves a major role in the maintenance of the<br />
acid-base balance. In the normal pH range of blood, the NH4+ /<br />
NH3 is about 100.<br />
Reliability: (2) valid with restrictions<br />
reliable review<br />
10-APR-<strong>20</strong>06 (11)<br />
Type:<br />
Absorption<br />
Remark: Absorption of sulfate depends on the amount ingested. 30-44%<br />
of sulfate was excreted in the 24-h urine after oral<br />
administration of magnesium or sodium sulfate (5.4 g sulfate)<br />
in volunteers. At high sulfate doses that exceed intestinal<br />
absorption, sulfate is excreted in feces. Intestinal sulfate<br />
may bind water into the lumen and cause diarrhoea in high<br />
doses. Sulfate is a normal constituent of human blood and does<br />
not accumulate in tissues. Sulfate levels are regulated by the<br />
kidney through a reabsorption mechanism. Sulfate is usually<br />
eliminated by renal excretion. It has also an important role<br />
in the detoxification of various endogenous and exogenous<br />
compounds, as it may combine with these to form soluble<br />
sulfate esters that are excreted in the urine.<br />
Reliability: (2) valid with restrictions<br />
reliable review<br />
10-APR-<strong>20</strong>06 (110)<br />
5.1 Acute Toxicity<br />
5.1.1 Acute Oral Toxicity<br />
Type:<br />
Species:<br />
Strain:<br />
Sex:<br />
Vehicle:<br />
Doses:<br />
Value:<br />
LD50<br />
rat<br />
no data<br />
male/female<br />
other: water (test substance was applied as a 30 % aqueous<br />
solution)<br />
2500, 3<strong>20</strong>0, 4000, 5000, 6400 mg/kg bw<br />
= 4250 mg/kg bw<br />
Method:<br />
other: see Test Condition<br />
Year: 1969<br />
GLP:<br />
no<br />
UNEP PUBLICATIONS 145