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Mathias FINK - Institut d'études scientifiques de Cargèse (IESC)

Mathias FINK - Institut d'études scientifiques de Cargèse (IESC)

Mathias FINK - Institut d'études scientifiques de Cargèse (IESC)

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Photoacoustic tomography (PAT), combining optical and ultrasonic waves via the photoacoustic<br />

effect, provi<strong>de</strong>s in vivo multiscale non-ionizing functional and molecular imaging. PAT is the only<br />

modality capable of imaging across the length scales of organelles, cells, tissues, and organs with<br />

consistent contrast. PAT has the potential to empower multiscale systems biology and accelerate<br />

translation from microscopic laboratory discoveries to macroscopic clinical practice. PAT may also<br />

hold the key to the earliest <strong>de</strong>tection of cancer by in vivo label-free quantification of<br />

hypermetabolism, the quintessential hallmark of cancer. Time-reversed ultrasonically enco<strong>de</strong>d<br />

(TRUE) optical focusing is based on ultrasonic modulation of coherence light propagating in<br />

scattering tissue followed by time reversal of the ultrasonically enco<strong>de</strong>d light component. TRUE<br />

focusing can noninvasively <strong>de</strong>liver light to a dynamically <strong>de</strong>fined focus <strong>de</strong>ep in a scattering<br />

medium. This technology opens the door to an even greater paradigm-shifting opportunity—one<br />

that controls the photon paths to minimize transmission loss in tissue.<br />

Pr. Martin Wegener<br />

Transformation materials for optics, elastodynamics, and thermodynamics<br />

I review our experimental efforts regarding implementing the i<strong>de</strong>as of transformation optics in the<br />

areas of optics, mechanics, and thermodynamics. This requires <strong>de</strong>signing and fabricating artificial<br />

materials with intentionally spatially inhomogeneous and/or anisotropic effective material<br />

properties. In optics, visible-frequency broadband polarization-in<strong>de</strong>pen<strong>de</strong>nt three-dimensional<br />

carpet cloaks have become possible. In mechanics, broadband two-dimensional free-space cloaks<br />

have been <strong>de</strong>monstrated and pentamo<strong>de</strong> metamaterials for three-dimensional architectures are<br />

emerging. In thermodynamics, two-dimensional free-space cloaks have recently become possible -<br />

bringing us back to the beginnings of the field, i.e., to the Cal<strong>de</strong>ron tomography problem.<br />

Pr. Nikolay Zhelu<strong>de</strong>v<br />

What’s matter with meta matter ?<br />

We report on recent <strong>de</strong>velopments in metamaterials and nanophotonics research. Out particular<br />

focus will be on coherent control of signals with metamaterials, generation of vector potential fields<br />

with toroidal structures and using photonic network as oracle for solving complex <strong>de</strong>cision<br />

problems.<br />

Pr. Clau<strong>de</strong> Boccara<br />

Random behavior in optical coherence<br />

The randomness of the refractive in<strong>de</strong>x and/or the position of the scatterers blur the images in<br />

biological tissues. OCT by selecting singly backscattered photons is a first approach that allows<br />

overcoming this problem. Even with incoherent sources the OCT signal exhibits a speckle<br />

distribution. Despite of the speckle in the images the Full Field OCT (FFOCT) approach that we<br />

have <strong>de</strong>veloped allows to reveal the tissue morphology at the micron scale and starts to be a<br />

valuable tool in intra operative surgery. Sometimes the morphology is not enough to characterize<br />

the tissue, so we will examine the basic nature of the signal and what kind of supplementary<br />

information can be extracted from the OCT data such as local refractive in<strong>de</strong>x, <strong>de</strong>nsity of scatterers<br />

and elasticity map. Finally (because we are in Cargese !) I will shows how FFOCT is used to count<br />

and characterize, through their Brownian trajectories, viruses in see water.<br />

Pr. Rémi Carminati<br />

Weak and strong coupling regimes of light-matter interaction in nanoscale disor<strong>de</strong>red media<br />

The interplay between multiple scattering, near-field interactions and material resonances in

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