Invasive breast carcinoma - IARC

Fig. 1.67 Lobular carcinoma of breast. Immunohistochemical staining of a lobular breast carcinoma with a
mutated CDH1 gene. Normal duct epithelium shows positive staining for membrane associated E-cadherin,
which is lacking in tumour cells.
in breast cancer to varying degre e s
{265,680}. Unfort u n a t e l y, collation of
LOH data into a coherent map has been
complicated enormously by the use of
d i ff e rent terminology and technology in
this area {679}. A tumour specific loss of
an allele, but also an imbalance in allele
intensities (allelic imbalance) are both
called LOH. LOH is often equated with
'deletion' although it may also be
caused by somatic re c o m b i n a t i o n .
Complete loss of an allele can only be
reliably and unequivocally measured in
tumour DNA samples with very low levels
of contamination from non-malignant
cells (i.e.