Invasive breast carcinoma - IARC

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Previous volumes in this series Kleihues P., Cavenee W. K . (Eds.): World Health Org a n i z a t i o n Classification of Tu m o u r s . Pathology and Genetics of Tumours of the Nerv o u s System. IARC Press: Lyon 2000 I S B N 92 83 22409 4 Hamilton S.R., Aaltonen L.A. (Eds.): World Health Org a n i z a t i o n Classification of Tu m o u r s . Pathology and Genetics of Tumours of the Digestive System. IARC Press: Lyon 2000 ISBN 92 83 22410 8 J a ffe E.S., Harris N.L., Stein H., Va rdiman J.V. (Eds.): World Health Org a n i z a t i o n Classification of Tu m o u r s . Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon 2001 ISBN 92 83 22411 6 Fletcher C.D.M., Unni K.K., Mertens F. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press: Lyon 2002 ISBN 92 832 2413 2 This book and all other volumes of the series can be purchased from: International Agency for IARCPress IARCPress Research on Cancer (IARC) 150 Cours Albert Thomas 1775 K Street, NW, Suite 480 69008 Lyon (France) Washington, DC 20006 (USA) Tel. +33 4 72 73 85 15 Toll-free order line: 877 WHO-IARC Fax +33 4 72 73 83 02 Fax (202) 223 1782 press@iarc.fr iarcpress@who.int World Health Organization (WHO) WHO Marketing and Dissemination WHO Publications Center 1211 Geneva (Switzerland) Albany, NY 12210 (USA) Tel. +41 22 791 2476 Tel. (518) 436 9686 Fax +41 22 791 4857 Fax (518) 436 7433 bookorders@who.ch qcorp@compuserve.com Oxford University Press (OUP) OUP Oxford (UK) Tel. +44 1536 454534 24 hr. Hotline: Tel. +44 1 536 74 17 27 Fax +44 1 865 26 77 82 book.orders@oup.co.uk WHO Blue Books on the web: www.iarc.fr/who-bluebooks
Page 5 and 6: World Health Organization Classific
Page 7 and 8: This volume was produced in collabo
Page 9 and 10: Contents 1 Tumours of the breast 9
Page 11 and 12: WHO histological classification of
Page 13 and 14: Stage Grouping Stage 0 Tis N0 M0 St
Page 15 and 16: Fig. 1.02 Incidence of female breas
Page 17 and 18: similar effects within different po
Page 19 and 20: A B Fig. 1.09 Mammographic demonstr
Page 21 and 22: Fig. 1.11 Invasive ductal carcinoma
Page 23 and 24: Fig. 1.15 Invasive carcinomas with
Page 25 and 26: A Fig. 1.19 Mammography of invasive
Page 27 and 28: Treatment of ILC should depend on t
Page 29 and 30: ment associated with a minor (
Page 31 and 32: eadily recognizable. The tumours ra
Page 33 and 34: Table 1.07 Criteria for the differe
Page 35 and 36: evidence of neuroendocrine diff e r
Page 37 and 38: p redominantly of apocrine cells co
Page 39 and 40: Fig. 1.42 Squamous cell carcinoma.
Page 41 and 42: Fig. 1.48 Mucoepidermoid carcinoma.
Page 43 and 44: Lobular neoplasia F.A. Tavassoli R.
Page 45 and 46: lesions {1707}, suggesting that bot
Page 47 and 48: DIN terminology is used, the tradit
Page 49 and 50: Synonyms Ductal intraepithelial neo
Page 51 and 52: u p period currently available for
Page 53 and 54:
are rare. Some require complete inv
Page 55 and 56:
these added studies, the distinctio
Page 57 and 58:
Microinvasive carcinoma I.O. Ellis
Page 59 and 60:
Intraductal papillary neoplasms G.
Page 61 and 62:
Table 1.15 Differential diagnosis o
Page 63 and 64:
population (featuring epithelial an
Page 65 and 66:
Fig. 1.53 Secretory carcinoma. The
Page 67 and 68:
A B Fig. 1.58 Adenoid cystic carcin
Page 69 and 70:
Table 1.09 G l y c o g e n - r i c
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of synchronous cancers has been rep
Page 73 and 74:
A B Fig. 1.66 Poorly differentiated
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1 6 q 2 2 : C D H 1. The cell-cell
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f i r s t - d e g ree re l atives o
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nent only. There is often poor corr
Page 81 and 82:
Fig. 1.73 A Supervised classificati
Page 83 and 84:
A B Fig. 1.109 A Apocrine adenosis/
Page 85 and 86:
Fig. 1.119 Sclerosing adenosis with
Page 87 and 88:
Myoepithelial lesions F.A. Tavassol
Page 89 and 90:
Table 1.17 Immunoprofile of various
Page 91 and 92:
Pseudoangiomatous stromal hyperplas
Page 93 and 94:
Fig. 1.136 Fibromatosis. Fascicles
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lipoma {1645}, hibernoma {2425} and
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in all grade I and most grade II an
Page 99 and 100:
A Fig. 1.145 Leiomyoma. A The well
Page 101 and 102:
Fig. 1.148 Phyllodes tumour. A well
Page 103 and 104:
A Fig. 1.153 Periductal stroma sarc
Page 105 and 106:
Tumours of the nipple V. Eusebi K.T
Page 107 and 108:
A B Fig. 1.158 Paget disease of the
Page 109 and 110:
Fig. 1.160 CD20 immunoexpression in
Page 111 and 112:
Tumours of the male breast K. Prech
Page 113 and 114:
M a c r o s c o p y The majority of
Page 115 and 116:
WHO histological classification of
Page 117 and 118:
TNM and FIGO classification of tumo
Page 119 and 120:
Fig. 2.02 Serous adenocarcinoma. Th
Page 121 and 122:
Fig. 2.05 Serous borderline tumour.
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Fig. 2.08 Non-invasive peritoneal i
Page 125 and 126:
Fig. 2.12 Serous surface papilloma.
Page 127 and 128:
Table 2.03 Primary vs. metastatic m
Page 129 and 130:
A Fig. 2.24 Mucinous borderline tum
Page 131 and 132:
A Fig. 2.29 Ovarian endometrioid ad
Page 133 and 134:
A Fig. 2.31 Sertoliform endometroid
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Clinical features M o re than 70% o
Page 137 and 138:
Prognosis and predictive factors Th
Page 139 and 140:
Fig. 2.43 Clear cell adenocarcinoma
Page 141 and 142:
Transitional cell tumours Definitio
Page 143 and 144:
Malignant Brenner tumour Definition
Page 145 and 146:
mixed Brenner-mucinous cystic tumou
Page 147 and 148:
Sex cord-stromal tumours F.A. Tavas
Page 149 and 150:
Fig. 2.62 Juvenile granulosa cell t
Page 151 and 152:
A B Fig. 2.67 Fibroma. A The sectio
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f i b roblasts and round cells and
Page 155 and 156:
A Fig. 2.76 Poorly differentiated S
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muscle may appear cellular and of f
Page 159 and 160:
mitotic rate may be present in thes
Page 161 and 162:
Unclassified sex cord-stromal t u m
Page 163 and 164:
162 Tumours of the ovary
Page 165 and 166:
A B C Fig. 2.88 Dysgerminoma. A Thi
Page 167 and 168:
A B Fig. 2.90 Yolk sac tumour. A Th
Page 169 and 170:
Fig. 2.96 Embryoid body in polyembr
Page 171 and 172:
Fig. 2.99 Mature cystic teratoma. T
Page 173 and 174:
c a rcinomas are difficult to diagn
Page 175 and 176:
A B Fig. 2.108 Strumal carcinoid. A
Page 177 and 178:
Mixed germ cell-sex cord-stromal tu
Page 179 and 180:
A B Fig. 2.112 Mixed germ cell-sex
Page 181 and 182:
Tumours and related lesions of the
Page 183 and 184:
Miscellaneous tumours and tumour-li
Page 185 and 186:
A Fig. 2.119 Hepatoid carcinoma. A
Page 187 and 188:
hydropic chorionic villi with ciste
Page 189 and 190:
A Fig. 2.124 Luteoma of pregnancy.
Page 191 and 192:
Differential diagnosis Stromal hype
Page 193 and 194:
A Fig. 2.129 Precursor T-cell lymph
Page 195 and 196:
A B Fig. 2.131 Krukenberg tumour. A
Page 197 and 198:
A mal luteinization, can be confuse
Page 199 and 200:
A Fig. 2.139 Multicystic peritoneal
Page 201 and 202:
A Fig. 2.142 Leiomyomatosis periton
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tumour size less than 5 x 5 mm {257
Page 205 and 206:
Page 207 and 208:
Tumours of the fallopian tube I. Al
Page 209 and 210:
A Fig. 3.05 Endometrioid carcinoma
Page 211 and 212:
incidental finding {659,1591}. Rare
Page 213 and 214:
Tumours of the uterine ligaments S.
Page 215 and 216:
A Fig. 3.15 Papillary cystadenoma a
Page 217 and 218:
genic effects, have been re p o rt
Page 219 and 220:
Page 221 and 222:
TNM and FIGO classification of gest
Page 223 and 224:
administration or to endogenous hyp
Page 225 and 226:
Table 4.01 Grading of type I (endom
Page 227 and 228:
Differential diagnosis The much mor
Page 229 and 230:
A B Fig. 4.15 Simple hyperplasia. A
Page 231 and 232:
Fig. 4.19 Endometrial polyp. The gl
Page 233 and 234:
and many examples with corre l a t
Page 235 and 236:
A Fig. 4.26 Low grade endometrial s
Page 237 and 238:
Fig. 4.29 Undifferentiated endometr
Page 239 and 240:
Histopathology The usual leiomyosar
Page 241 and 242:
Fig. 4.34 Leiomyomas. The sectioned
Page 243 and 244:
Intravenous leiomyomatosis Intraven
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cause obvious diagnostic pro b l e
Page 247 and 248:
A B C Fig. 4.43 Carcinosarcoma. A A
Page 249 and 250:
sarcomatous component, usually of h
Page 251 and 252:
Gestational trophoblastic disease D
Page 253 and 254:
A Fig. 4.48 Epithelioid trophoblast
Page 255 and 256:
origin, the mitochondrial DNA is of
Page 257 and 258:
Clinical findings The patients typi
Page 259 and 260:
CHAPTER 5 Tumours of the Uterine Ce
Page 261 and 262:
TNM and FIGO classification of carc
Page 263 and 264:
Fig. 5.02 A marked decrease in the
Page 265 and 266:
Fig. 5.06 Sagittal T2-weighted MRI
Page 267 and 268:
Histopathology There have been few
Page 269 and 270:
s t romal invasion often appears to
Page 271 and 272:
Cells typical of carcinoma in situ
Page 273 and 274:
who had a mucinous adenocarcinoma o
Page 275 and 276:
The tubular variant is distinguishe
Page 277 and 278:
Histopathology Endocervical polyps
Page 279 and 280:
A Fig. 5.35 Large cell neuroendocri
Page 281 and 282:
have been reported {543,912,927,104
Page 283 and 284:
Fig. 5.40 Venous haemangioma. Vascu
Page 285 and 286:
Epidemiology Cervical adenosarcomas
Page 287 and 288:
Melanotic, germ cell, lymphoid and
Page 289 and 290:
A Fig. 5.48 Metastatic gastric carc
Page 291 and 292:
Page 293 and 294:
Table 6.01 Terminology of premalign
Page 295 and 296:
High grade VAIN appears to be an im
Page 297 and 298:
A Fig. 6.12 Adenosis of the vagina.
Page 299 and 300:
cell adenocarcinoma, mesonephric ca
Page 301 and 302:
Mesenchymal tumours A.G. Östör Va
Page 303 and 304:
Prognosis and predicitive factors D
Page 305 and 306:
Mixed epithelial and mesenchymal tu
Page 307 and 308:
Melanotic, neuroectodermal, lymphoi
Page 309 and 310:
Fig. 6.25 Peripheral primitive neur
Page 311 and 312:
CHAPTER 7 Tumours of the Vulva Squa
Page 313 and 314:
TNM classification of carcinomas of
Page 315 and 316:
Fig. 7.01 Squamous cell carcinoma,
Page 317 and 318:
A B Fig. 7.05 Vulvar intraepithelia
Page 319 and 320:
A B Fig. 7.09 Fibroepithelial polyp
Page 321 and 322:
Table 7.02 Immunohistochemical find
Page 323 and 324:
Syringoma Definition A benign epith
Page 325 and 326:
A Fig. 7.16 Epithelioid sarcoma of
Page 327 and 328:
Deep angiomyxoma Definition A local
Page 329 and 330:
Melanocytic tumours E.J. Wilkinson
Page 331 and 332:
Dysplastic melanocytic naevus Defin
Page 333 and 334:
CHAPTER 8 Inherited Tumour Syndrome
Page 335 and 336:
family cancer database {715}, a sli
Page 337 and 338:
of hormone independence of BRCA1- a
Page 339 and 340:
dent gland formation with intermedi
Page 341 and 342:
cance, was the discovery of direct
Page 343 and 344:
east surveillance using MRI suggest
Page 345 and 346:
of TP53 mutation and p53 expression
Page 347 and 348:
2323}. Both proteins co-exist with
Page 349 and 350:
cient power to determine the effect
Page 351 and 352:
These modifications result in the i
Page 353 and 354:
Cowden syndrome C. Eng D e f i n i
Page 355 and 356:
acting in the phosphoinositol-3-kin
Page 357 and 358:
Genetics of MLH1, MSH2, MSH6 Chromo
Page 359 and 360:
cancer seemed to be reduced while e
Page 361 and 362:
ATM protein is detected and missens
Page 363 and 364:
Dr Rosalind EELES Translational Can
Page 365 and 366:
Dr Johannes L. PETERSE* Department
Page 367 and 368:
Source of charts and photographs 1.
Page 369 and 370:
References 1 . Anon. (1982). The Wo
Page 371 and 372:
1 1 4 . Aozasa K, Saeki K, Ohsawa M
Page 373 and 374:
244. Berkowitz RS, Cramer DW, Berns
Page 375 and 376:
369. Bur ME, Zimarowski MJ, Schnitt
Page 377 and 378:
501. Claus EB, Risch NJ, Thompson W
Page 379 and 380:
623. Daroca PJ Jr. (1987). Medullar
Page 381 and 382:
757. Eichhorn JH, Scully RE (1991).
Page 383 and 384:
882. Fisher RA, Lawler SD, Ormerod
Page 385 and 386:
1004. Gilks CB, Young RH, Aguirre P
Page 387 and 388:
1132. Hanselaar AG, Boss EA, Massug
Page 389 and 390:
1262. Hughesdon PE (1982). Ovarian
Page 391 and 392:
1387. Kaku T, Kamura T, Shigematsu
Page 393 and 394:
1511. Kotylo PK, Michael H, Davis T
Page 395 and 396:
1624. Lele SB, Piver MS, Barlow JJ,
Page 397 and 398:
1750. Maluf FC, Sabbatini P, Schwar
Page 399 and 400:
1870. Miller B, Flax S, Dockter M,
Page 401 and 402:
1995. Nesland JM, Lunde S, Holm R,
Page 403 and 404:
2116. Ordonez NG, Mackay B (2000).
Page 405 and 406:
2240. Phelan CM, Rebbeck TR, Weber
Page 407 and 408:
2367. Richardson WW (1956). Medulla
Page 409 and 410:
2499. Rutledge F (1967). Cancer of
Page 411 and 412:
2622. Seidman JD, Borkowski A, Aisn
Page 413 and 414:
2746. Somerville JE, Clarke LA, Big
Page 415 and 416:
2878. Tavassoli FA, Andradre R, Mer
Page 417 and 418:
3001. Vang R, Medeiros LJ, Silva EG
Page 419 and 420:
3125. Willemsen W, Kruitwagen R, Ba
Page 421 and 422:
3256. Zheng W, Khurana R, Farahmand
Page 423 and 424:
Subject index A Acantholytic varian
Page 425 and 426:
DCIS, see Ductal carcinoma in situ
Page 427 and 428:
Koilocytosis, 267, 270, 271, 294, 2
Page 429 and 430:
Placental site nodule, 211, 252, 25
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Invasive breast carcinoma - IARC

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