Invasive breast carcinoma - IARC

distinguishes this tumour from the
Krukenberg tumour. All of the re p o rt e d
cases are benign.
Sertoli-stromal cell tumours
Fig. 2.73 Well differentiated Sertoli-Leydig cell
tumour. The tumour shows well developed tubules
lined by Sertoli cells and aggregates of Leydig cells.
nous or oedematous tissue. The cellular
a reas contain prominent thin-walled
vessels with varying degrees of sclerosis
admixed with both spindle and
round cells, the latter may re s e m b l e
luteinized theca cells or show perinuclear
vacuolization.
Histochemical studies show the activity
of stero i d o g e n e s i s - related enzymes
{1575,2537} and immunoreactivity for
desmin and smooth muscle actin, as
well as vimentin {419,1419,2512,2637}.
Prognosis and predictive factors
The tumour is benign, and there have
been no re c u r rent cases.
Signet-ring stromal tumour
D e f i n i t i o n
A rare stromal tumour composed of
signet-ring cells that do not contain
mucin, glycogen or lipid {697,2332,
2 6 0 5 , 2 8 1 1 } .
Clinical findings
This tumour occurs in adults and is hormonally
inactive.
M a c r o s c o p y
M a c roscopically the tumours, may be
both solid and cystic or uniformly solid.
D e f i n i t i o n
Tumours containing in pure form or in
various combinations Sertoli cells, cells
resembling rete epithelial cells, cells
resembling fibroblasts and Leydig cells
in variable degrees of diff e re n t i a t i o n .
ICD-O codes
S e rtoli-Leydig cell tumour gro u p
Well diff e re n t i a t e d 8631 / 0
Of intermediate diff e re n t i a t i o n 8631/1
With heterologous elements 8634 / 1
Poorly diff e re n t i a t e d 8631 / 3
With heterologous elements 8634 / 3
R e t i f o rm 8633 / 1
With heterologous elements 8634 / 1
S e rtoli cell tumour, NOS 8640 / 1
Sertoli-Leydig cell tumour
g r o u p
D e f i n i t i o n
Tumours composed of variable pro p o r-
tions of Sertoli cells, Leydig cells, and in
A
Fig. 2.74 T1 weighted MR image of a Sertoli-Leydig
cell tumour that fills the abdomen.
the case of intermediate and poorly diff
e rentiated neoplasms, primitive
gonadal stroma and sometimes hetero l-
ogous elements.
S y n o n y m
A n d ro b l a s t o m a .
E p i d e m i o l o g y
S e rtoli-Leydig cell tumours (SLCTs) are
r a re, accounting for