From the Practice - Biologische Heilmittel Heel GmbH

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Journal of 

Biomedical 

Therapy 

Volume 3, Number 1 ) 2009 

Integrating Homeopathy 

and Conventional Medicine 

Neuroendocrine 

Dysfunction 

• Psychogenic Factors in Gastrointestinal Pathology 

• Bioregulatory Treatment of Dysautonomia

) 

Contents 

In Focus 

Applied Bioregulation in Neuroendocrine Disease: 

Chronic Stress . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 

What Else Is New? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 

Fr o m t h e P ra c t i c e 

Metabolic and Endocrine Disorders Associated 

With Pseudarthrosis: Presentation of a Clinical Case . . . . . . 10 

Around the Globe 

Verona – More Than Just Romeo and Juliet ... . . . . . . . . . . . . . 15 

Practical Protocols 

Bioregulatory Treatment of Dysautonomia . . . . . . . . . . . . . . 16 

In memoriam 

Professor Michael F. Kirkman . . . . . . . . . . . . . . . . . . . . . . . . . . 17 

Re f re s h Yo u r H o m o t ox i c o l o g y 

Psychogenic Factors in Gastrointestinal Pathology . . . . . . . 18 

M a r ke t i n g Yo u r P ra c t i c e 

Communication in Your Practice . . . . . . . . . . . . . . . . . . . . . . . 20 

Specialized Applications 

The Acupuncture Approach to the 

Hypothalamus-Pituitary-Adrenal Axis . . . . . . . . . . . . . . . . . . 22 

Making of ... 

Manufacturing of Traumeel Injection Solution 

Part I: From Work Preparation to Filling . . . . . . . . . . . . . . . . . 26 

Meet the Expert 

Dr. Arturo O’Byrne . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 

Cover photograph © Sebastian Kaulitzki/Fotolia.de 

Research Highlights 

Nervoheel N vs. Lorazepam for Mild Nervous Disorders . . . 30 

) 2 

Published by/Verlegt durch: International Academy for Homotoxicology GmbH, Bahnackerstraße 16, 

76532 Baden-Baden, Germany, e-mail: journal@iah-online.com 

Editor in charge/verantwortlicher Redakteur: Dr. Alta A. Smit 

Print/Druck: VVA Konkordia GmbH, Dr.-Rudolf-Eberle-Straße 15, 76534 Baden-Baden, Germany 

© 2009 International Academy for Homotoxicology GmbH, Baden-Baden, Germany

) 

Stress and the Immune System 

Dr. Alta A. Smit 

Psychoneuroimmunology (PNI) 

has come a long way since Walter 

Cannon’s early work with animals. 

Cannon observed that any 

change in emotional state (such as 

anxiety, distress, or rage) was accompanied 

by total cessation of stomach 

movements. Cannon’s research culminated 

in his seminal work, Bodily 

Changes in Pain, Hunger, Fear and 

Rage, published in 1915. 1 

Hans Selye then drew on Cannon’s 

research for his own animal experiments. 

Selye subjected animals to a 

variety of adverse physical and mental 

conditions and observed consistent 

adaptations that allow the body 

to heal and recover. The General 

Adaptation Syndrome Selye described 

is still important in bioregulatory 

medicine today. 2 

Even conventional medicine increasingly 

recognizes the mind-brain 

connection and psychoneuroendocrinoimmunology 

(PNEI). For instance, 

stress at work is associated 

with cardiovascular risk factors such 

as BMI, hypertension, and lipid levels. 

The Whitehall studies examined 

this possible larger relationship between 

work stress and cardiovascular 

disease in depth. 3 

Bioregulatory medicine recognizes 

and tests for autonomic dysfunction 

as one of the main obstacles to regulatory 

ability in patients. For example, 

heart rate variability is one of 

the main risk factors for cardiac disease. 

4 

In this issue, we present a variety of 

articles on the effects of stress on the 

immune system, which have been 

well-known for decades. In the focus 

article, Dr. Jesús Agudo gives a 

general introduction to the subject. 

Dr. Mónica Name presents a case 

study demonstrating the effect of 

bioregulatory medicines on bone 

healing. Dr. Butch Levy examines 

the role of acupuncture in the treatment 

of autonomic dysfunction, and 

Dr. Bert Hannosset contributes a 

treatment protocol for dysautonomia. 

In Research Highlights, we present the 

results of a study investigating the 

effectiveness of Nervoheel in mild 

nervous disorders, and our marketing 

specialist offers tips on successful 

communication with your patients. 

We also examine how ampoule 

medications are manufactured (Part 

1) and continue our Meet the Expert 

series with an introduction to Dr. 

Arturo O’Byrne of Colombia. 

It is with great sadness that we remember 

another expert, Professor 

Michael Kirkman. His sudden death 

this year leaves a huge void in the 

world of homotoxicology. Dr. Damir 

Shakambet, who worked closely 

with Professor Kirkman in the UK, 

contributes a heartfelt obituary. 

Dr. Alta A. Smit 

References 

1. Quick JC, Spielberger CD. Walter Bradford 

Cannon: Pioneer of stress research. 

International Journal of Stress Management. 

1994;1(2):141-143. 

2. Selye H. A syndrome produced by diverse nocuous 

agents. Nature. 1936;138(3479):32. 

3. Marmot M. UCL Department of Epidemiology 

and Public Health: Whitehall II Study. 

2008. UCL web site. http://www.ucl.ac.uk/ 

whitehallII/. Updated February 27, 2008. 

Accessed July 14, 2009. 

4. Institute of HeartMath Research Staff. Science 

of the heart: exploring the role of the 

heart in human performance. Institute of 

HeartMath web site. http://www.heartmath. 

org/research/research-science-of-the-heart. 

html. Accessed July 14, 2009. 

) 3 

Journal of Biomedical Therapy 2009 ) Vol. 3, No. 1

) In Focus 

Applied Bioregulation in Neuroendocrine Disease 

Chronic Stress 

By Jesús Agudo, MD 

) 4 

Chronic stress is often a reaction to the stimuli of a more 

or less hostile environment, to which most people living 

in the 21st century have succumbed. With increasing 

clarity, chronic stress is shown to be a causative agent of 

numerous diseases, especially those of neuroendocrine 

origin. A new cross-functional medical specialization is 

appearing, propelled by increasingly detailed knowledge 

about the biological foundations of the relationship 

between stress and a variety of diseases: psychoneuroimmunology. 

The history of medicine has been 

a constant struggle between 

monism and dualism, between those 

researchers who consider the human 

being to be a unit and those who see 

in the individual the confluence of 

2 separate entities: physical and 

spiritual, material and immaterial, 

metabolism and emotions, body and 

soul. 

If we go back some 2,600 years, 

Hippocrates had already declared 

that health was a state inherent to 

the individual, whom nature had endowed 

with self-healing abilities. 

Furthermore, while a person lived in 

harmony with nature, his or her 

health would be maintained or, were 

it lost, could easily be recovered. 

Disease was only an imbalance resulting 

from a failure to observe the 

rules of Hygeia. Thus, the physician’s 

mission would be to help individuals 

recover the lost equilibrium 

and teach them to live in 

accordance with the laws of nature 

(vis medicatrix naturae). 

In contrast, students of the school of 

Aesculapius believed that for every 

disease there was a determined 

cause, a separate treatment, and 

some organs or systems involved, 

and that the most prestigious physician 

was the one who made the diagnosis 

and prescribed the correct 

treatment. This compartmentalized 

and highly specialized vision is that 

which now dominates “modern” 

medicine, one in which the idea of 

the individual is, incorrectly, not 

considered to be an indivisible entity, 

a single unit with one material 

component and another apparently 

immaterial component. 

Fortunately, in the second half of 

the 20th century, the development 

of that highly specialized and fragmented 

medicine, with an impressive 

ability to delve into the core of 

the most subtle physiological processes, 

converged with the other, 

more humanist medicine descended 

from Hippocrates, which pays attention 

to the psycho-emotional aspects 

of humankind. We could say that 

the more cartesian-reductionist and 

more fiercely material medicine has 

discovered the influence of the human 

soul on physiopathological 

processes. 

It is, therefore, absolutely fascinating 

that more than 2,000 years ago, 

the pineal gland was described by 

Galen, who credited it with the ability 

to regulate the flow of thought; 

in the 17th century, it was described 

by Descartes as the seat of the rational 

soul. What is surprising is the 

insight, from ancient times, that this 

area would be the gateway between 

body and soul and the approximation 

of what was being described to 

what we know today about the interrelationships 

between emotions 

and their physical responses. 

The study of the relationships between 

mind and body has been 

termed psychoneuroimmunology, 

and what we are truly faced with is 

the most refined, holistic concept of 

medical science. 


) In Focus 

Stress 

Brain 

A 

Adrenaline 

ACh+ 5-HT+ IL-1+ CRH+ GABA- NA+/– 

+ 

– 

IL-1 RA 

NA 

ACh 

GABA 

Noradrenaline 

Acetylcholine 

γ-Aminobutyric acid 

Hypothalamus 

CRH+ 

AVP+ 

Pituitary 

– 

– 

IL-1, IL-6, TNF-a 

Monocytes 

Macrophages 

5-HT 

5-Hydroxytryptamine 

IL-1 RA Interleukin 1 

receptor antagonist 

TNF 

IL 

ACTH 

Tumor necrosis factor 

Interleukin 

Corticotropin 

NA/A+ 

ACTH+ 

AVP 

Arginine vasopressin 

Adrenal gland 

Cortisol +/– 

CRH 

Corticotropinreleasing 

hormone 

Figure 1: Relationship between the cortex, hypothalamus, pituitary gland, 

and adrenal glands (after Lack and Wright 1 ) 

The hypothalamic- 

pituitary-adrenal system 

The stimuli generated in the cerebral 

cortex by adverse situations such as 

stress or various pathological mental 

processes will create a response in 

the limbic system that triggers the 

release of several neurotransmitters 

(e.g., acetylcholine, 5-hydroxytrypta 

mine, interleukin [IL] 1, corticotropin-releasing 

hormone [CRH], 

γ-aminobutyric acid [GABA], and 

noradrenaline). These neurotransmitters 

will ultimately activate the 

hypothalamic-pituitary-adrenal axis 

according to the cascade described 

later (Figure 1). 

Corticotropin-releasing hormone 

and arginine vasopressin (AVP) are 

produced in the paraventricular nuclei 

of the hypothalamus. These substances 

are carried to the anterior 

pituitary gland, where they regulate 

the secretion of adrenocorticotropic 

hormone (ACTH or corticotropin). 

Adrenocorticotropic hormone travels 

through the bloodstream to the 

cortex of the adrenal glands, where 

it stimulates the synthesis and release 

of glucocorticoids (GCs). 

In turn, these GCs exert a negative 

feedback on several targets, including 

the adrenal cortex, inhibiting 

their own secretion; the pituitary 

gland, inhibiting ACTH production; 

and even the hypothalamus itself, 

down-regulating the release of 

ACTH and AVP. Glucocorticoids 

also act on the hypothalamus 

through the production of GABA, 

which ultimately inhibits this organ’s 

synthesis of CRH and AVP. 

Another intermediate feedback regulator 

of the release of CRH in this 

process would be the one exerted on 

the noradrenergic and serotonergic 

neurons. 2 

Finally, we must not forget that the 

brain will also exert an influence on 

the sympathetic and endocrine system 

by means of the CRH that regulates 

the sympathetic nervous system. 

This has nerve endings in the 

bone marrow, thymus, and spleen, 

which are the cell factories responsible 

for cellular and humoral immunity. 

The psychoneuroimmuno 

logy of stress 

It is now clear that CRH plays a 

fundamental role in the response to 

stress. Administration of CRH produces 

a broad suppression of immune 

functions similar to that observed 

in depression or chronic 

stress. 


regulates immune functions through 

a central pathway and a peripheral 

pathway. By means of the central 

pathway, it notably suppresses the 

proliferation of lymphocytes and 

phagocytosis by neutrophils while 

increasing the number of neutrophils 

and cellular aggregation. It also 

decreases the quantity and activity 

of natural killer (NK) cells and 

IgG levels. In the peripheral pathway, 

its activity is based on the CRH 

receptors that exist on macrophages, 

monocytes, and helper lymphocytes. 


reduces the replication and survival 

of spleen cells while simultaneously 

encouraging the migration of monocytes. 

) 5 


) In Focus 

) 6 

We have already seen how stress activates 

the production of CRH directly 

in the hypothalamus and indirectly 

through noradrenergic and 

serotonergic neurons. However, it 

also activates the autonomic nervous 

system. For these tasks, mediation 

by intermediaries such as acetylcholine, 

IL-1, and serotonin is required. 

Meanwhile, to balance this reaction, 

stress-inhibiting substances are also 

present, such as GABA; opioid peptides, 

whose producing neurons are 

closely related to CRH-producing 

neurons to establish an equilibrium; 

and a third group (e.g., adrenaline/ 

noradrenaline) that acts on various 

senses. 

With respect to the sympathetic nervous 

system, we could say that in 

states of stress it will be activated by 

CRH, and on being stimulated, it 

will produce adrenaline and noradrenaline. 

Peripherally, these substances 

will trigger a series of actions, 

such as an increase in blood 

pressure, blood glucose, heart rate, 

alertness, and vigilance, and inhibit 

the sensation of hunger and growth 

through the suppression of growth 

hormone (GH). 

Stress affects various 

vital areas 

The immune system 

According to recent studies, the role 

of cortisol in the inhibition of the 

immune system appears to consist of 

suppressing the ability of immune 

cells to activate their own telomerase 

to reproduce their telomeres each 

time the cell divides. The telomere 

would, therefore, be shortened, a 

characteristic observed in pathological 

conditions, such as human immunodeficiency 

virus infection, osteoporosis, 

coronary heart disease, 

and even aging. 3 

Cancerous diseases 

Stress significantly reduces the activity 

of NK cells. 4 In laboratory experiments 

on animals subjected to 

stress, the rate of pulmonary metastases 

from induced breast cancers 

doubled. 

Studies of women who underwent 

surgery for carcinoma of the breast 

have also shown a significantly reduced 

NK cell count in patients with 

high stress levels compared with 

those who controlled their stress, resulting 

from uncertainty about the 

treatment or prognosis of their disease. 

5 

Infectious diseases 

In laboratory experiments on animals 

subjected to stress conditions, 

their response to the flu virus decreased 

significantly. Along with 

high levels of plasma corticosterone, 

a decrease in the mononuclear cell 

population and a 60% to 95% decrease 

in IL-2 production in lymphoid 

organs were observed. 

In preschool-aged children subjected 

to various situations of environmental 

stress, several changes in the 

CD4, CD8, and NK cell counts were 

observed, which have been correlated 

with respiratory diseases. 4 

Another experiment conducted on 

astronauts found that during periods 

of stress, there was a decrease in antibodies 

to the Epstein-Barr virus 

nuclear antigens, along with an increase 

in adrenaline and noradrenaline 

in the urine and a decrease in 

virus-specific T lymphocytes. This 

led to the reactivation of the Epstein-Barr 

virus in 11 of 28 astronauts. 

6 

Wound healing 

There also appears to be evidence 

from in vitro studies showing that 

fibroblasts would be less effective in 

matrix repair for recovery from injuries 

and wounds in situations of psychological 

stress, precisely because 

of the presence of high tissue levels 

of corticosteroids. In one study of 

student volunteers who underwent 

small incisions on mucous membranes, 

the healing time was 40% 

longer during examination periods 

than during vacation periods. This 

longer duration was associated with 

a 30% decrease in IL-1 levels during 

examination periods. 7 

Stress and allergies 

In a joint experiment, physicians 

and psychologists studied the relationship 

between stressful situations 

and an increase in the most common 

signs of allergies (rhinitis, sneezing, 

coughing, and conjunctivitis), along 

with the peculiarity that the allergic 

symptoms worsened in the following 

days while the stress stimulus 

continued. Analytically, this translates 

to a significant increase in IL-6 

and catecholamines in the blood of 

stressed patients with symptoms of 

allergies. 

There is another mediator, vasoactive 

intestinal polypeptide, that has 

been found in increased quantities 

in children who have experienced 

significant stress (typically parental 

separation) and that is closely linked 

to sensitization and the onset of allergic 

phenomena. 9 

In another recent experiment performed 

in Canada, 10 it was found 

that maternal stress in the first 7 

years of the child’s life has a significant 

influence on the rates of childhood 

asthma because mothers in 

this situation are less likely to interact 

with and show affection to their 

children. This is recognized by the 

child’s immune system, which could 

be considered an “affective” transmission 

of stress. 


) In Focus 

Systemic lupus erythematosus, 

depression, and stress 

Distinct immunological changes 

have been found in patients with depressive 

syndromes of various degrees 

and clinical manifestations. 11 

In contrast to healthy control subjects, 

an increase in B lymphocytes, 

antinuclear antibodies, and serum 

immunoglobulins can be observed 

in patients with depressive syndromes. 

Thus, depressive illnesses 

can demonstrate a certain relationship 

to autoimmunity. Also, many 

autoimmune diseases are characterized 

by major episodes of depression, 

especially systemic lupus erythematosus, 

regardless of treatment 

with GCs. 

With depression in general, prolonged 

activity in the adrenal cortex 

is a factor that makes recovery notably 

difficult. These are patients in 

whom the administration of corticosteroids 

does not exert a negative 

feedback on their own cortisol levels. 

12 

Growth and stress 

As previously mentioned, sustained 

stress causes high levels of CRH, 

which in turn inhibits GH and insulinlike 

growth factor 1. The circulating 

corticosteroids also exert a 

negative feedback on GH production 

by the pituitary gland. 2 

Stress and sleep 

Patients experiencing stress have a 

poor quality of sleep as a cause and 

a result of stress. 5,13 Failure to follow 

circadian rhythms due to a lack of 

sleep reduces the amount of melatonin 

in the blood to below required 

levels. It is, therefore, presumed that 

its antioxidant activity cannot be 

performed. Also, melatonin’s likely 

activity of promoting immunity by 

inhibiting the production of gonadotropins 

is inhibited. 1,14 

Bioregulatory approach to 

stress 

A fascinating opportunity remains 

open for bioregulatory medicine to 

establish treatment protocols consisting 

of immune regulatory medicines 

(e.g., Echinacea compositum 

and Engystol), medicines supporting 

brain function (e.g., Cerebrum 

compositum, Thalamus compositum, 

Ypsiloheel, Neuro-Injeel, Tonico-Injeel, 

Nervoheel, and Ignatia- 

Homaccord), and the classic 

organoregulators, such as Ovarium 

compositum, Pulsatilla compositum, 

Coenzyme compositum, Hepar 

compositum, Testis compositum, 

Thyreoidea compositum, Galium- 

Heel, and Ubichinon compositum. 

Neurexan, a medication for nervousness 

and insomnia, has recently been 

shown in preliminary studies to be 

possibly useful in anticipatory anxiety. 

15 | 

References 

1. Lack LC, Wright HR. Chronobiology 

of sleep in humans. Cell Mol Life Sci. 

2007;64(10):1205-1215. 

2. Rosales Estrada M. Síndrome de inflamación de 

las mucosas: tratamiento antihomotóxico. Colombia: 

M. Rosales Estrada; 2005. 

3. Choi J, Fauce SR, Effros RB. Reduced telomerase 

activity in human T lymphocytes 

exposed to cortisol. Brain Behav Immun. 

2008;22(4):600-605. 

4. Song C, Leonard BE. Fundamentals of Psychoneuroimmunology. 

Chichester, England: 

Wiley & Sons; 2000. 

5. Andersen BL, Farrar WB, Golden-Kreutz 

D, et al. Stress and immune responses after 

surgical treatment for regional breast cancer. 

J Natl Cancer Inst. 1998;90(1):30-36. 

6. Stowe RP, Pierson DL, Barrett AD. Elevated 

stress hormone levels relate to Epstein-Barr 

virus reactivation in astronauts. Psychosom 

Med. 2001;63(6):891-895. 

7. Glaser R, Kiecolt-Glaser JK. Stress-induced 

immune dysfunction: implications for health. 

Nat Rev Immunol. 2005;5(3):243-251. 

8. Stress, anxiety can make allergy attacks even 

more miserable and last longer. ScienceDaily 

Web site. http://www.sciencedaily.com/ 

releases/2008/08/080814154327.htm. 

Published August 17, 2008. Accessed July 

14, 2009. 

9. Stress during childhood increases the risk of 

allergies. e! Science News Web site. http:// 

esciencenews.com/articles/2008/06/18/ 

stress.during.childhood.increases.risk.allergies. 

Published June 18, 2008. Accessed 

July 14, 2009. 

10. Kozyrskyj AL, Mai XM, McGrath P, Hayglass 

KT, Becker AB, Macneil B. Continued 

exposure to maternal distress in early life is 

associated with an increased risk of childhood 

asthma. Am J Respir Crit Care Med. 

2008;177(2):142-147. 

11. Eiguchi K, Soneira SG. Psiconeuroinmunoendocrinología 

en enfermedades autoinmunes 

(LES). Archivos de Alergia e Inmunología Clínica. 

2002;33(suppl 1):S8-S16. 

12. McEwen BS. Physiology and neurobiology 

of stress and adaptation: central role of the 

brain. Physiol Rev. 2007;87(3):873-904. 

13. Zisapel N. Sleep and sleep disturbances: biological 

basis and clinical implications. Cell 

Mol Life Sci. 2007;64(10):1174-1186. 

14. Plant TM. Hypothalamic control of the pituitary-gonadal 

axis in higher primates: key 

advances over the last two decades. J Neuroendocrinol. 

2008;20(6):719-726. 

15. Dimpfel W. Psychophysiological effects of 

neurexan on stress-induced etropsychograms: 

a double blind, randomized, placebo-controlled 

study in human volunteers. 

NeuroCode-AG Web site. http://www. 

neurocode-ag.com/Poster%20Stresskongress%20Teil%20A.pdf 

and http://www. 

neurocode-ag.com/Poster%20Stresskongress%20Teil%20B.pdf. 

Accessed July 14, 

2009. 

) 7 


Hearing voices when there is nobody 

around? A recent study suggests that 

high caffeine consumption may 

increase a pre-existing tendency 

to hallucinate. 

Getting a good night’s sleep reduces 

the risk of catching a viral infection. 

Link between caffeine and 

hallucinations? 

The more expensive 

the better? 

For good health, 

get enough sleep 

) 8 

A new research study, conducted at 

Durham University, UK, examines a 

possible link between high caffeine 

consumption and an increased tendency 

to hallucinate. The study assessed 

typical caffeine consumption 

of 200 students, along with stress 

levels and proneness to common 

hallucinatory experiences such as 

hearing voices when no one is present. 

“High caffeine users” consuming 

more than the equivalent of 

seven cups of instant coffee a day 

were three times more likely to hear 

voices than “low users” consuming 

less than one cup-equivalent. 

What’s the theory behind this research? 

As a result of traumatic 

events in their past, many hallucination-prone 

individuals respond to 

current stress by producing increased 

amounts of the stress hormone cortisol. 

Caffeine consumption further 

increases release of the stress hormone, 

and this extra cortisol boost 

might exacerbate a pre-existing tendency 

to hallucinate. 

The authors call the findings a first 

step in better understanding how 

nutrition affects hallucinations. More 

research is needed to see if changes 

in caffeine intake might help people 

to better cope with distressing hallucinations 

or reduce the frequency 

of these experiences. 

Personality and Individual Differences. 

2009;46(4):562-564. 

“If it’s not expensive, it can’t be any 

good.” Many people seem to approach 

medical care with this attitude. In an 

American study, 82 healthy volunteers 

were given what they thought 

was a new pain reliever. In reality, all 

of the subjects received identical 

placebos, but half of them were told 

that the price per tablet was $2.50, 

while the others were allowed to believe 

the medication was very lowpriced. 

The analge sic effects of the 

fake medication were then tested using 

mild electrical shocks to induce 

pain. Subjective sen sations of pain 

were significantly reduced in the 

group receiving the supposedly 

more expensive medication in comparison 

to the other group. 

JAMA. 2008;299:1016-1017 

Enjoy food and lose weight 

Eating rapidly to the point of satiety 

increases the risk of obesity. When 

3,287 Japanese women and men 

were surveyed about their eating 

habits, respondents who said they 

tended to eat fast until they felt full 

were three times more likely to be 

overweight than people who ate 

slowly and enjoyed their food. It 

seems that weightwatchers should 

not only pay attention to what they 

eat but also to how they eat. 

BMJ. 2008;337:a2002 

People who sleep well and long 

enough are less susceptible to viral 

infections, according to a study of 

153 healthy men ranging in age 

from 21 to 55 years. The subjects 

were surveyed about the quantity 

and quality of their sleep over a 14- 

day period, after which they were 

infected by administering nose 

drops containing rhinoviruses. Researchers 

found that subjects who 

slept longer and better got sick less 

often than participants who slept 

less. For example, participants who 

got eight hours of sleep or more 

were approximately 2.94 times less 

likely to catch colds than those who 

slept for seven hours or less. The effects 

of sleep efficiency (actual sleeping 

time as a percentage of total time 

in bed) were even greater: Participants 

with 92 percent efficiency or 

less were 5.5 times more likely to 

develop a cold than those with 98 

percent efficiency or more. The immune 

system appears to need adequate 

sleep to effectively fend off 

germs. 

Arch Intern Med. 2009;169(1):62-67 


) What Else Is New? 

During a coughing attack, airborne 

pathogens will be propelled into the 

surrounding air for about four meters. 

Sexy women wear red 

“Red-light” districts and sexy red 

lingerie suggest that the color red 

has long been associated with male 

sexual drive, but this connection had 

never been scientifically confirmed. 

To test men’s responses to the color 

red in relationship to women’s sexual 

attractiveness, participants were 

shown photos of women in front of 

different colored backgrounds. Other 

pictures showed the women wearing 

different colored tops. The study 

found that men saw women posing 

in front of a red background or 

wearing red tops as sexually more 

desirable than the same women in 

other photos. Red had no effect on 

the men’s assessment of the women’s 

other qualities such as intelligence 

or kindness. Women shown the 

same photos seemed to be colorblind 

when it came to rating the attractiveness 

of other women. 

J Pers Soc Psychol. 2008;95(5):1150- 

1164 

Communicating with 

patients through positive 

images 

We humans still think best in images, 

and abstract numbers are difficult 

for most of us to remember. Health 

care practitioners should also use 

this fact to their advantage and enhance 

their communication with patients 

by using pictures and graphic 

elements. Researchers from New 

Zealand recently investigated the 

best way to convey important information 

about treatments to patients. 

Two-thirds of the patients questioned 

preferred graphically presented 

information to pure numbers 

and percentages. Positive formulations 

were also considered help ful. 

In other words, it is generally better 

to emphasize the benefits of a particular 

therapy instead of stressing 

the possible risks of leaving a condition 

untreated. 

Ann Fam Med 2008;6(3):213-217 

Keep your distance to 

stay healthy 

Many diseases are transmitted by 

airborne drops. At work, in the subway, 

while shopping – wherever we 

meet other people, we are bombarded 

with germs. People who are already 

sick and coughing are especially 

likely to contaminate the air 

with germ-filled spray. A recent 

study investigated how fast this 

cloud spreads around a cougher. 

Scien tists from the USA calculated 

the speed of spread at up to eight 

meters per second over a period of 

approximately half a second. This 

means that an attack of coughing 

propels germs into the surroundings 

for about four meters. Anyone who 

wants to make it through cold season 

unscathed would do well to 

keep their distance from other people. 

N Engl J Med. 2008;359(15):e19 

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articles in this journal. 

The purpose of the Journal of Biomedical Therapy is to share worldwide scientific information about successful protocols from orthodox and complementary practitioners. 

The intent of the scientific information contained in this journal is not to “dispense recipes” but to provide practitioners with “practice information” for a better 

understanding of the possibilities and limits of complementary and integrative therapies. 

Some of the products referred to in articles may not be available in all countries in which the journal is made available, with the formulation described in any article or 

available for sale with the conditions of use and/or claims indicated in the articles. It is the practitioner’s responsibility to use this information as applicable 

and in a manner that is permitted in his or her respective jurisdiction based on the applicable regulatory environment. We encourage our readers to share 

their complementary therapies, as the purpose of the Journal of Biomedical Therapy is to join together like-minded practitioners from around the globe. 

Written permission is required to reproduce any of the enclosed material. The articles contained herein are not independently verified for accuracy or truth. They have 

been provided to the Journal of Biomedical Therapy by the author and represent the thoughts, views and opinions of the article’s author. 

) 9 


) From the Practice 

Metabolic and Endocrine Disorders 

Associated With Pseudarthrosis 

Presentation of a Clinical Case 

Mónica Name Guerra, MD 

Bone fatigue is a considerable risk factor causing fractures 

in high-performance athletes, as a result of many extrinsic 

and intrinsic factors. This article describes a 13-year-old 

girl, a professional skater with a fracture of the femur and 

atrophic pseudarthrosis 10 months after initial surgical 

treatment. A metabolic disturbance was found at the 

biological medical consultation; this was managed 

holistically, and the patient’s fracture healed after 

2 months of antihomotoxic and integrative treatment. 

The use of unsuitable equipment, 

very intensive training schedules, 

and inappropriate diets are 

among the external risk factors that 

predispose towards bone pathology 

in athletes. Age; mechanical biophysical 

factors arising from the 

bone-muscle relationship, which alter 

physiological alignment; bone 

density; and metabolic or hormonal 

imbalances are intrinsic causes of 

stress fractures and pseudarthrosis. 

Prepubertal girls and women, as a 

result of the physiological changes 

inherent to their sexual development 

and monthly hormonal fluctuation, 

are a population especially at risk. 1 

In 1986, the US Food and Drug 

Administration defined pseudarthrosis 

as nonhealing of a fracture 

9 months after injury. However, depending 

on the bone and the site of 

the injury, this period may vary. In 

fractures of the long bones in the 

middle third of the femur, a waiting 

period of 6 months is allowed, 

whereas neck fractures should heal 

within 3 months after the trauma. 2 

Although the exact cause of pseudarthrosis 

is not clear, it is believed that 

local factors (e.g., infection and poor 

vascularization) and systemic factors 

(e.g., nutritional state and hormonal 

balance) contribute to nonhealing of 

fractures. Although there are opposing 

opinions, there is considerable 

bibliographic evidence implicating 

nonsteroidal anti-inflammatory 

drugs and corticoids as important 

factors in fractures that are not healing. 

3 

Pseudarthrosis can be hypertrophic 

or hypervascularized and atrophic 

or avascular. 

Figure 1: Fracture 

Figure 2: Intramedullary pin 

(June 26, 2004) 

Figure 3: Pseudarthrosis at follow-up 

) 10 



Figure 4: Second operative procedure 

Figure 5: Postoperative view 5 months 

after the second operative procedure 

Clinical case 

The patient is a 13-year-old sportsperson 

who, on June 25, 2004, experienced 

a displaced fracture in the 

middle third of the right femur (Figure 

1), which required surgical treatment 

with an intramedullary pin 

(Figure 2). 

A 5-month postoperative followup 

X-ray showed pseudarthrosis 

(Figure 3). Thus, from an orthopedic 

viewpoint of the mechanical instability 

and hypertrophic pseudarthrosis, 

a further intervention changing 

the pin for one of a larger 

diameter with double distal locking 

was performed on November 17, 

2004 (Figure 4). 

Five months after the second operative 

procedure, the fracture was classified 

as atrophic pseudarthrosis 

(Figure 5), and the treating orthopedic 

surgeon proposed a third intervention. 

The patient decided to consult 

a biological medicine specialist 

to obtain a second opinion. 

The consultation on April 13, 2005, 

showed that the patient was in pain, 

with no support from the lower 

right limb, and had a high consumption 

of nonsteroidal anti-inflammatory 

drugs. 

The results of the Meridian Stress 

Assessment (developed by Reinhold 

Voll) were pancreatic and splenic 

dysfunction (Table 1); therefore, 

clinical laboratory tests were performed 

to complete the investigation 

(Table 2). These test results 

showed a state of hypercortisolism 

with a normal basal insulin level (no 

postprandial insulin test result was 

available). The postprandial glucose 

response at 30 minutes was normal; 

however, at 1 hour, it was very low. 

The thyrotropin level was in the 

normal range, the free thyroxine 

level was normal, and the triiodothyronine 

level was not obtained. The 

parathyroid hormone level was normal; 

the result of bone densitometry 

showed osteopenia. 

Organ Right side Left side 

Lymphatic deg. 48 46 

Lung 54 46 

Large intestine 34 56 

Central nervous 

system deg. 

42 46 

Circulation 46 48 

Allergy deg. 42 42 

Parenchyma deg. 34 42 

Endocrine 46 46 

Heart 52 46 

Small intestine 44 58 

Pancreas 18 

Spleen 16 

Liver 44 46 

Joint deg. 46 36 

Stomach 54 52 

Fibroid deg. 58 48 

Skin deg. 66 58 

Fat deg. 56 58 

Gallbladder 70 52 

Kidney 54 52 

Bladder 48 56 

Uterus/prostate 48 54 

Laboratory test Patient value Reference value 

Urinary cortisol, µg/24 h 60.86 5-55 

Basal blood glucose, mg/dL 79 70-105 

Postprandial blood glucose at 30 min, mg/dL 125 > 110 

Postprandial blood glucose at 1 h, mg/dL 74 120-170 

Postprandial blood glucose at 2 h, mg/dL 94 70-120 

Thyrotropin, µUI/mL 2.40 0.35-5.50 

Free thyroxine, ng/dL 1.06 0.93-1.70 

Parathyroid hormone, pg/mL 31.3 11.0-79.5 

Basal insulin, µU/mL 5.02 2.60 -24.90 

Table 1: 

Meridian Stress Assessment results* 

Table 2: 

Clinical laboratory results 

* Normal values, 40-60; Irritation, 61-80; 

Inflammation, 81-100; Weakness, 31-39; 

Degeneration, < 30 

) 11 



Figure 6: Consolidated fracture (June 23, 

2005) 

) 12 

Treatment was started as follows: 

• Osteoheel, 

1 tablet 4 times per day 

• Strumeel, 

1 tablet 4 times per day 

• Momordica compositum, 

1 ampoule twice weekly, 

10 doses 

• Placenta compositum, 


10 doses 

• Acidum citricum-Injeel, 


10 doses 

• Lymphomyosot, 1 ampoule 

twice weekly, 10 doses 

Nutritional changes reducing the intake 

of rapidly absorbed carbohydrates 

(refined sugars) and avoiding 

high-sodium processed foods (ready 

meals and fast food) were recommended. 

At the 2-month clinical follow-up, 

pain was absent, normal electrical 

measurements of the pancreas (44) 

and spleen (48) were noted, and radiography 

showed healing of the 

fracture (Figure 6); therefore, the intramedullary 

pin was removed (Figure 

7). Laboratory findings at the 

end of treatment were normal. 

Discussion 

According to the Meridian Stress 

Assessment, this patient had an abnormality 

of the pancreas. Her low 

glucose level, using the result of the 

oral glucose tolerance test at 60 

minutes, indicates hypoglycemia and 

a state of chronic hypercortisolism. 

This state of transitory hypoglycemia 

leads to a functional imbalance 

of the hypothalamus-pituitary-adrenal 

cortex axis 4-6 ; therefore, the response 

is an increase in β-adrenergic 

activity in the hypothalamus, with 

the release of the growth hormones 

somatotrophin and corticotropin 

and increased secretion of cortisol 

and epinephrine. 5,6 

The cortisol acts like a counterregulating 

hormone and induces the 

production of glucose, activating the 

gluconeogenesis pathway. If the hypoglycemia 

persists, the level of cortisol 

rises, conforming a state of 

chronic hypercortisolism. 

The increased cortisol levels in this 

patient could be secondary to the 

hypoglycemia and stress produced 

by competitive exercise and the influence 

of interleukin 6 as a chronic 

inflammatory cytokine. 7 

Intense exercise by high-performance 

athletes suppresses the function 

of the T cells and natural killer 

cells and increases the release of 

cortisol and interleukin 6 proinflammatory 

factors. 7 

Cortisol causes a reduction in bone 

formation and an increase in resorption 

by various mechanisms 

(Figure 8). 8 

Cortisol antagonizes the action of 

1,25-dihydroxyvitamin D 3 

or calcitriol, 

which acts on the osteoblast by 

increasing the synthesis of tissue 

growth factor β (TGF-β) and raising 

the number of insulinlike growth 

factor receptors, whose anabolic effect 

regulates bone growth and tissue 

repair. 8-12 Vitamin D 3 

increases 

the synthesis of osteocalcin and osteopontin 

by improving the mineralization 

of the collagen fibrils of 

the bone when they are depleted. 

9-12 

The formation of hydroxyapatite alters 

with sodium/calcium interchange 

in the renal distal tubules, 

where phosphorus and magnesium 

are also lost. Each gram of sodium 

ion in urine corresponds to 26.3 mg 

of lost calcium; therefore, salty and 

fast food diets are not recommended. 

13 

Ingesting oily seeds and extra virgin 

vegetable oils rich in polyunsaturated 

fatty acids and conjugated linoleic 

acid increases the absorption 

rate of calcium in the cells and reduces 

osteoclastogenesis. 14 

Acidification secondary to the ingestion 

of refined sugar and proteins 

with sulfur atoms (methionine and 

cysteine) alters the mineralization 

and metabolism of the bone. 9 

The concentration of protons in the 

plasma and in the extracellular fluid 

is about 40 nM, corresponding to a 

pH of 7.4; to stabilize and alkalize 

this, there are systems that include 

balancing phosphate with calcium 

and magnesium ions originating 

from the bone matrix at the expense 

of weakening the bone. 9 

According to the personal analysis 

that I have made of this clinical case, 



Figure 7: Fracture without intramedullary 

pin (November 28, 2006) 

antihomotoxic medications could 

hypothetically have acted in the following 

manner in healing the fracture: 

1. Antihomotoxic medications, 

which contain low doses of antigens, 

could have stimulated the 

production of TGF-β from the 

lymphocyte line T-helper cell 3. 

This TGF-β intervenes in the reconstruction 

of the bone matrix 

by inhibiting the activation of 

the osteoclasts and stimulating 

the action of the osteoblasts, 

promoting the healing of the tissue 

and the resolution of the inflammation. 

15-18 

2. The bioregulatory effect of Momordica 

compositum in the 

pancreas in controlling hypoglycemia 

and secondary hypercorti 

solism could be the result 

of a possible improvement in the 

expression of glucotransporters 

in the cells and hypothetically 

might increase the secretion 

of amylin and preptin. These 

2 polypeptides are cosecreted 

with insulin from the β cells of 

the pancreas; their function is to 

stimulate osteoblastic proliferation, 

reduce osteoblastic apoptosis, 

and inhibit osteoclastic activity. 

19-25 

3. Possibly, Acidum citricum-Injeel, 

a Krebs cycle catalyst and calcium 

metabolism regulator that 

improves the absorption of vitamin 

D, could act in the renal tubule 

cells by stimulating the mitochondrial 

1a-hy droxylase res 

pon sible for transforming 25- 

hydroxycholecalciferol (in acti ve) 

into 1,25-dihydroxy cholecalciferol 

(active) or calcitriol. 

Figure 8: Effects of cortisol on bone 8 

GI Ca absorption 

Renal Ca absorption 

Bone resorption 

LH – FSH 

Testosterone 

Estrogen 

Cortisol 

Osteoprotegerin 

Osteoporosis 

Muscle strength 

Osteoblastic 

apoptosis 

GI 

Ca 

Gastrointestinal 

Calcium 

Bone formation 

LH 

Luteinizing 

hormone 

Growth factors 

FSH 

Follicle-stimulating 

hormone 

) 13 



) 14 

Conclusion 

Antihomotoxic treatment drains the 

matrix (Lymphomyosot), regulates 

the endocrine function of the pancreas 

(Momordica compositum), 

regulates thyroid function (Strumeel), 

solves the problem of avascular atrophic 

pseudarthrosis (Placenta compositum), 

and re-establishes the 

metabolic balance of bone, the intrinsic 

calcium metabolism, and vitamin 

D absorption (Osteoheel and 

Acidum citricum-Injeel). 

Pseudarthrosis is not an exclusively 

mechanical problem. It must be confronted 

integrally, from the profession 

or lifestyle to the metabolism of 

the organism, the diet, the neuroendocrine 

system, and immunological 

modulation. “The whole organism 

suffers with the fracture of a long 

bone.” 26 | 

References 

1. DeFranco MJ, Recht M, Schils J, Parker RD. 

Stress fractures of the femur in athletes. Clin 

Sports Med. 2006;25(1):89-103, ix. 

2. Cleveland KB. Delayed union and nonunion 

of fractures. In: Canale ST, Beaty J, eds. 

Campbell’s Operative Orthopaedics. 11th ed. 

Philadelphia, PA: Mosby; 2007:chapter 56. 

3. Koester MC, Spindler KP. Pharmacologic 

agents in fracture healing. Clin Sports Med. 

2006;25(1):63-73, viii. 

4. Fruehwald-Schultes B, Kern W, Born J, 

Fehm HL, Peters A. Hyperinsulinemia 

causes activation of the hypothalamus-pituitary-adrenal 

axis in humans. Intern J Obes. 

2001;25(suppl1):S38-S40. 

5. Arias P, Arzt E, Bonet E. Estrés y procesos de 

enfermedad. Buenos Aires, Argentina: Biblos; 

1998. 

6. Suliman AM, Freaney R, McBrinn Y, et al. 

Insulin-induced hypoglycemia suppresses 

plasma parathyroid hormone levels in patients 

with adrenal insufficiency. Metabolism. 

2004;53(10):1251-1254. 

7. Rosales Estrada M. Síndrome de inflamación 

de las mucosas: tratamiento antihomotóxico. 

2nd ed. Colombia: M. Rosales Estrada; 

2005. 

8. Rubin MR, Bilezikian JP. The role of parathyroid 

hormone in the pathogenesis of 

glucocorticoid-induced osteoporosis: a reexamination 

of the evidence. J Clin Endocrinol 

Metab. 2002;87(9):4033-4041. 

9. Koolman J, Röhm K. Bioquímica: texto y atlas. 

3rd ed. Stuttgart, Germany: Panamericana; 

2004. 

10. Clark R. The somatogenic hormones and 

insulin-like growth factor-1: stimulators of 

lymphopoiesis and immune function. Endocr 

Rev. 1997;18(2):157-179. 

11. Kurtz A, Matter R, Eckardt KU, Zapf J. 

Erythropoiesis, serum erythropoietin, and serum 

IGF-I in rats during accelerated growth. 

Acta Endocrinol (Copenh). 1990;122(3):323- 

328. 

12. Gómez JM. The role of insulin-like growth 

factor I components in the regulation of vitamin 

D. Curr Pharm Biotechnol. 2006;7(2):125- 

132. 

13. Shortt C, Madden A, Flynn A, Morrissey PA. 

Influence of dietary sodium intake on urinary 

calcium excretion in selected Irish individuals. 

Eur J Clin Nutr. 1988;42(7):595-603. 

14. Bhattacharya A, Banu J, Rahman M, Causey 

J, Fernandes G. Biological effects of conjugated 

linoleic acids in health and disease. 

J Nutr Biochem. 2006;17(12):789-810. 

15. Abbas AK, Lichtman AH, Pillai S. Inmunología 

celular y molecular. 6th ed. Barcelona, 

Spain: Elsevier Saunders; 2008:3-16, 243- 

263, 267-301. 

16. Heine H. Homotoxicología: Una síntesis de las 

orientaciones médicas basadas en las ciencias 

naturales. 3rd ed. Baden-Baden, Germany: 

Aurelia-Verlag; 2004:79-85. 

17. Weiner HL, Mayer LF. Oral tolerance: mechanisms 

and applications. Ann N Y Acad Sci. 

1996;778:1-451. 

18. Weiner HL, Friedman A, Miller A, et al. 

Oral tolerance: immunologic mechanisms 

and treatment of animal and human organspecific 

autoimmune diseases by oral administration 

of autoantigens. Annu Rev Immunol. 

1994;12:809-837. 

19. Cornish J, Callon KE, Bava U, et al. Preptin, 

another peptide product of the pancreatic 

β-cell, is osteogenic in vitro and in vivo. Am 

J Physiol Endocrinol Metab. 2007;292(1): 

E117-E122. 

20. Dacquin R, Davey RA, Laplace C, et al. Amylin 

inhibits bone resorption while the calcitonin 

receptor controls bone formation in 

vivo. J Cell Biol. 2004;164(4):509-514. 

21. Valenzano KJ, Heath-Monnig E, Tollefsen 

SE, Lake M, Lobel P. Biophysical and biological 

properties of naturally occurring high 

molecular weight insulin-like growth factor 

II variants. J Biol Chem. 1997;272(8):4804- 

4813. 

22. Buchanan CM, Phillips AR, Cooper GJ. 

Preptin derived from proinsulin-like growth 

factor II (proIGF-II) is secreted from pancreatic 

islet β-cells and enhances insulin secretion. 

Biochem J. 2001;360(pt 2):431-439. 

23. Alam AS, Moonga BS, Bevis PJ, Huang CL, 

Zaidi M. Amylin inhibits bone resorption by 

a direct effect on the motility of rat osteoclasts. 

Exp Physiol. 1993;78(2):183-196. 

24. Cornish J, Callon KE, Cooper GJ, Reid IR. 

Amylin stimulates osteoblast proliferation 

and increases mineralized bone volume in 

adult mice. Biochem Biophys Res Commun. 

1995;207(1):133-139. 

25. Cornish J, Callon KE, King AR, Cooper GJ, 

Reid IR. Systemic administration of amylin 

increases bone mass, linear growth, and adiposity 

in adult male mice. Am J Physiol Endocrinol 

Metab. 1998;275(4, pt 1):E694-E699. 

26. Sodi-Pallares D. Magnetoterapia y tratamiento 

metabólico. Publisher unknown; 1994:84. 


) Around the Globe 

Verona – More Than 

Just Romeo and Juliet ... 

By Anita Bania, MD 

From November 6 to 8, 2008, in 

Verona, Italy, the International 

Academy for Homotoxicology presented 

a practice-based training for 

Polish doctors whose practices combine 

conventional medical training 

with elements of homeopathy, homotoxicology, 

acupuncture, homeosiniatry, 

and mesotherapy. The small 

group of students, all experienced 

clinicians, included three internal 

medicine specialists and two pediatricians. 

The training took place in Dr. Ivo 

Bianchi’s private medical practice, 

which he runs together with his wife 

and daughter. Dr. Bianchi sees patients 

of virtually all ages, ranging 

from infants to geriatric patients. 

The group had close contact with 

selected patients, had access to their 

histories, and was able to examine 

them. Each patient was then discussed 

in detail to determine individually 

optimized therapies and 

recommendations. 

Dr. Bianchi had invited two guest 

speakers to contribute to the training. 

Dr. Lugero Graziolli gave a lecture 

and practical demonstrations on 

“Esthetic Biological Medicine: Diagnosis 

and Therapies,” placing particular 

emphasis on biochemical and 

electromagnetic homeostasis in the 

Sightseeing in Verona 

human body and the loss of normal 

matrix functions in the course of the 

aging process. Professor Sergio Serrano 

introduced the therapeutic use 

of biophotons and singlet oxygen 

and demonstrated their practical applications 

in traditional mesotherapy 

and biomesotherapy to the group. 

Dr. Bianchi is a seasoned expert on 

Krebs cycle catalysts and enthusiastically 

endorses their use in therapy, 

both in his youngest patients (such 

as low birth-weight babies) and in 

mature and elderly patients. We analyzed 

individual clinical case studies 

under Dr. Bianchi’s guidance. From 

the perspective of conventional 

medicine, all of these cases were at 

least very interesting and often very 

challenging. All of Dr. Bianchi’s patients 

had undergone very thorough 

diagnosis, often in university hospitals, 

and their discharge summaries 

and hospitalization information 

were available. Dr. Bianchi conducted 

detailed repertorization of each 

individual patient, applying the 

rules of classical homeopathy and 

homotoxicology, and determined 

the position of each patient’s condition 

on a neurovegetative outline he 

has developed and enriched with 

additional elements drawn from homotoxicology, 

Chinese medicine, 

and conventional medicine. 

The training itself was very intense 

but well-organized, and the sessions 

were just the right length. Between 

sessions, we were also able to enjoy 

the charming sights of the town of 

Verona and see the international 

horse show gala HORSELYRIC, for 

which Verona is now famous. 

We found participating in this training 

to be highly rewarding and recommend 

it to all practitioners interested 

in homotoxicology and holistic 

medicine.| 

For more information on 

practice-based training in 

bioregulatory medicine, 

please contact the International 

Society of Homotoxicology 

and Homeopathy at 

info@isohh.de 

At the end of the training, the 

participants received certificates 

(far left and right: Dr. Ivo Bianchi 

and his wife Marina). 

) 15 


) Practical Protocols 

Bioregulatory Treatment 

of Dysautonomia 

By Bert Hannosset, MD 

Dysautonomia, formerly called 

neurasthenia, exists in two 

forms: familial dysautonomia and 

non-familial dysautonomia. 

Familial dysautonomia is an autosomal 

recessive genetic disease, the 

result of mutation in the IKBKAP 

gene on chromosome 9. It occurs 

exclusively in Ashkenazi Jews; there 

are currently 350 known living cases 

worldwide. To date, the disease 

remains incurable. 

Non-familial dysautonomia, a disease 

or malfunction of the autonomic 

nervous system, is much more 

common. In this disorder, the human 

body fails to properly regulate 

blood pressure (e.g., orthostatic hypotension), 

heart rate (e.g., postural 

orthostatic tachycardia syndrome), 

temperature, vascular constriction/ 

dilation, and blood supply to the 

brain. The results are unpredictable 

fainting, low blood pressure, lightheadedness, 

dizziness, problems 

with concentration (“brain fog”), 

headaches, fatigue, heart palpitations, 

exercise intolerance, insomnia, 

hot flashes, chills, weakness, seizures, 

pain, and disability. The causes 

of non-familial dysautonomia are 

not fully understood but are thought 

to include viral infections, exposure 

to toxic chemicals, genetic factors (a 

variation in the angiotensin II type I 

receptor gene), autoimmune disorders 

(antibodies to neuronal nicotinic 

acetylcholine receptors of the 

autonomic ganglia), adrenal disorders, 

and trauma (injury or emotional 

trauma, which damages the autonomic 

nervous system). (See protocol 

in Table 1.)| 

DET-phase 

Basic and/or 

symptomatic 

Regulation therapy* 

Optional 

Sympathicodermal 

Impregnation 

• Ignatia- 

Homaccord 

D&D 

IM 

• Advanced supportive 

detoxification and drainage 

followed by the 

• Detox-Kit 

• Tonsilla compositum 

• Vertigoheel (dizziness) 

• Tonico-Injeel (exhaustion) 

• Cralonin (cardiac weakness) 

• Aurumheel (low blood pressure) 

• Traumeel (injury) 

OR 

• Sympathicus suis-Injeel 

if available; if not, use 

• Engystol (post-viral) 

• Cerebrum compositum 

Notes: Ignatia and Moschus = basic homeopathic treatment for dystonia. Advanced supportive detoxification and drainage consists of 

Hepar compositum (liver), Solidago compositum (kidneys), and Thyreoidea compositum (connective tissue; also regulates glandular 

functions [e.g., pineal body, thyroid, and adrenals]); Coenzyme compositum and Ubichinon compositum for cellular detoxification and 

drainage. The Detox-Kit consists of Lymphomyosot, Nux-vomica-Homaccord, and Berberis-Homaccord. Tonsilla compositum downregulates 

the Th-2 pathway and supports adrenals. Sympathicus suis-Injeel supports the autonomic nervous system. Cerebrum compositum 

supports the central nervous system and improves blood flow. 

Dosages: Ignatia-Homaccord: 15 drops 3 times per day. Regulation therapy: 1 ampoule of each medication 1-3 times per week. Detox-Kit: 

30 drops o f each medication in 1.5 liters of water; drink throughout the day. 

) 16 

Table 1: Protocol for dysautonomia 

* Antihomotoxic regulation therapy consists of a three-pillar approach: detoxification & drainage (D&D), immunomodulation (IM), 

and organ regulation (OR) 


In memoriam 

Professor Michael F. Kirkman 

died on Saturday, January 18 on 

the Isle of Wight, United Kingdom. 

He had lectured at St. Andrew’s 

Medical School; his medical knowledge 

ranged from pathology and 

tropical diseases to homeopathy, homotoxicology, 

and nutrition. He was 

one of the first doctors to apply an 

integrative concept of medicine that 

included environmental factors and 

detoxification. 

He had the courage to challenge 

medical conventions and found 

himself in the first line of attack for 

his use of homeopathic sarcodes and 

nosodes. Like Drs. Reich, Gerson, 

Bach, and Reckeweg before him, his 

dogged persistency, academic ability, 

and zeal to advance the “art of medicine” 

enabled him to carry on with 

his mission. He wrote a textbook on 

tissue microenvironment and lectured 

and published articles worldwide. 

He was one of the first certified 

lecturers of the International 

Academy for Homotoxicology (IAH) 

and won an award for the best lecture 

at the first IAH rollout in Baden- 

Baden, Germany in April 2003. 

He founded not only one of the first 

nutritional colleges in the UK (the 

European College of Nutrition at 

the Royal Society for Public Health) 

but also the first College of Homotoxicology 

in the UK; with colleagues, 

he started the first postgraduate 

course in bioregulatory 

medicine. Last but not least, he was 

involved in teaching a course in bioregulatory 

medicine at the Biomedic 

Centre in the UK in collaboration 

with two colleagues, Drs Shakambet 

and Bosh. 

Professor Michael F. Kirkman 

(1936 – 2009) 

His guidance and support were crucial 

to those following this path, 

and he was full of warmth and enthusiasm 

for new projects. His mentorship, 

wise guidance, and friendship, 

along with his witty and 

creative mind, will be greatly missed. 

His funeral was held on February 4, 

2009 on the Isle of Wight. Professor 

Kirkman is survived by his wife 

Muriel. 

Damir A. Shakambet, MD 

Hans-Heinrich Reckeweg Award 2010 

Join in – have your experience rewarded 

Heel annually honors outstanding scientific research in 

the field of a unique homeotherapeutic system (homotoxicology) 

with the Hans-Heinrich Reckeweg Award. 

The main award (€ 10,000) 

is presented for scientific work of fundamental theoretical 

and/or practical significance in antihomotoxic 

medicine in the fields of human and veterinary medicine. 

The incentive award (€ 5,000) 

is presented for promising results arising from clinical, 

case-based or fundamental research in antihomotoxic 

medicine in the fields of human and veterinary medicine. 

The prize money is intended to fund further research. 

Both prizes are awarded for research carried out in a 

laboratory or registered practice. All results must be 

new, convincing and previously unpublished, and research 

should not have involved animal testing. 

The deadline for submissions is May 31, 2010. 

For more information contact: 

Biologische Heilmittel Heel GmbH, 

Department of Research, 

76532 Baden-Baden, Germany 

Phone +49 7221 501-227, 

Fax +49 7221 501-660, info@heel.de, 

www.heel.com 

) 17 


) Re f r e s h Yo u r H o m o t ox i c o l o g y 

Psychogenic Factors in 

Gastrointestinal Pathology 

By Bruno Van Brandt 

Medical Education Manager of the IAH 

) 18 

Is half a glass of water half full or half empty? Although the 

reality remains the same, the way individuals look at it will 

definitely change their emotional state. Half full or half 

empty makes the difference between positivism and negativism, 

between stress and inner peace, between psychogenic 

factors that will, over the ideomotorical rule in psychology,* 

enhance or inhibit physical condition or strength. 

Emotional triggers of immune 

disorders are very well-known 

in modern medicine, especially 

where psycho-neuro-endocrino-immunological 

(PNEI) effects are seen 

as a major trigger within psychosomatic 

diseases. 1 Serotonin, adrenaline, 

dopamine, and glutamate are 

major neurotransmitters in the central 

nervous system. Serotonin and 

adrenaline especially are secreted in 

response to stress and emotion. All 4 

neurotransmitters mentioned are 

also present in a second, almost prehistorical, 

and often forgotten brain, 

called the enteric brain. 

This enteric nervous system, located 

in the gastrointestinal (GI) tract 

(more precisely in the epithelial lining 

of the esophagus, stomach, and 

small and large intestines), is a major 

subject in the study of neurogastroenterology 

and plays an important 

role in irritable bowel syndrome 

(IBS). According to some researchers, 

up to 95% of the serotonin 

available in the body is located in 

the GI tract; of this 95%, 90% is in 

the enterochromaffin cells, and the 

remaining 10% can be found in enteric 

neurons. Serotonin plays a key 

role in the initiation of peristaltic 

and secretory reflexes. 2 

Although the enteric brain is described 

as part of the peripheral nervous 

system, it is also defined as the 

second brain, 3 in addition to the primary 

central brain. The central nervous 

system can influence the enteric 

brain and vice versa. 3 This 

could be a possible explanation as to 

why an emotional stressor or anxiety 

can indirectly induce IBS. 

During stress, the brain will induce, 

over the brain-gut axis, mast cell degranulation 

in the intestinal tract. 

By this degranulation, histamine 

and phospholipids are set free in 

large numbers, inducing inflammatory 

pathways. Activation of the gut 

immune system may disrupt normal 

gut motility, leading to common 

symptoms such as diarrhea, cramping, 

and bloating. 4 

The inflamed tissues render the enteric 

nerves overly sensitive and 

overactive, deregulating the production 

of serotonin. Both low and 

high levels of serotonin can cause 

problems. The same molecule, when 

available in a too low or a too high 

concentration, may induce the same 

clinical symptom: cramps. As Paracelsus 

already stated centuries ago, 

“the dose makes the poison.” 

Low levels of serotonin are not only 

associated with depression, shortterm 

memory, and concentration 

deficits, but also, at the level of the 

enteric nervous system, with bowel 

problems such as constipation with 

spasm (IBS-C). Emotional stress, 

over the PNEI system, can thus induce 

changes within serotonin levels 

at the level of the GI tract and can 

induce spasms (Figure 1). A stressrelated 

nervous or anxious state will 

increase the prevalence or intensity 

of intestinal spasm over the braingut 

axis. 5 

Increased levels of serotonin are associated 

with intestinal problems 

too, such as is seen in diarrhea 

accompanied by cramps (IBS-D). 6 

Selective serotonin reuptake inhibitor 

package inserts often mention 

both symptoms as possible adverse 

effects because of the medicationinduced 

decreased reuptake of serotonin 

and thus the increased serotonin 

availability and activity levels. 

* Every thought or idea makes the body gravitate to fulfill that thought or idea. William James, The Principles of Psychology (1890) 


) Re f r e s h Yo u r H o m o t ox i c o l o g y 

The conventional medical approach 

to IBS is often the use of antispasmodic 

agents, such as hyoscine butylbromide, 

to relieve spasms and 

cramps. Research in conventional 

medicine also reports the symptomrelieving 

effects of benzodiazepines 

in patients with IBS, 7,8 pointing at 

the psychogenic factors that increase 

the physical symptoms over the 

brain-gut axis. A combination therapy 

of an antispasmodic medication 

with a benzodiazepine seems to 

have synergic therapeutic effects in 

the relief of IBS symptoms. 9 Treatments 

aimed at the gut-brain interface 

are in development, but have 

been difficult to establish because of 

adverse effects. 10 

Bioregulatory treatment 

It is thus interesting to look at a bioregulatory 

approach in these patients. 

In a comparative study, Nervoheel 

was found to be noninferior 

to lorazepam, a benzodiazepine prescribed 

worldwide, in the treatment 

of mild nervous disorders. 11 Spascupreel 

is a bioregulatory antispasmodic 

medication that will induce 

symptomatic relief of spasmodic 

conditions of the intestinal tract. In 

a comparative study versus hyoscine 

butylbromide, it was shown to possess 

a noninferior therapeutic effect 

in treating intestinal cramps. 12 This 

effect of Spascupreel can be used in 

conditions such as IBS, and, if it is 

applied together with a psychogenic 

relaxing drug such as Nervoheel, a 

synergistic action on the gut-brain 

axis may be possible. In this way, a 

bioregulatory alternative can be offered 

for the combination of antispasmodic 

agent–tranquilizer in 

conventional therapy of IBS. 

Given the PNEI link between the 

central and enteric brain and the experience 

in conventional medicine 

(i.e., antispasmodic drugs in combination 

with tranquillizers have a 

stronger symptom-relieving effect in 

IBS), it can be stated that Nervoheel 

might play an important therapeutic 

role in the bioregulatory relief of 

IBS symptoms. Although some benzodiazepines 

are known to be addictive, 

13 to my knowledge, no such 

risk has ever been reported for Nervoheel. 

Thus, Nervoheel is a safe alternative 

to benzodiazepines. In the 

same way, Spascupreel is a safe and 

effective alternative to hyoscine butylbromide 

in the symptomatic relief 

of patients with IBS. Known adverse 

effects of hyoscine butylbromide include 

constipation, dry mouth, trouble 

urinating, and nausea. Other adverse 

effects, which are very unlikely 

but reported, include rash, itching, 

swelling of the hands or feet, trouble 

breathing, increased pulse, dizziness, 

diarrhea, vision problems, and 

eye pain. To my knowledge, none of 

these adverse effects have ever been 

reported with Spascupreel. 

In conclusion, bioregulatory treatment 

may offer a viable alternative 

Stress 

Mood disturbances 

• Anxiety 

• Depression 

Central nervous system (brain) 

Autonomic nervous system 

in the management of conditions in 

which the gut-brain interface causes 

deregulation of the enteric nervous 

system, the second brain.| 

References: 

1. Sivik T, Byrne D, Lipsitt D, Christodoulou G, 

Dienstfrey H, eds. Psycho-Neuro-Endocrino- 

Immunology (PNEI). Amsterdam, the Netherlands: 

Elsevier; 2002. Excerpta Medica 

International Congress Series 1241. 

2. Grider JR, Kuemmerle JF, Jin JG. 5-HT released 

by mucosal stimuli initiates peristalsis 

by activating 5-HT4/5-HT1p receptors 

on sensory CGRP neurons. Am J Physiol. 

1996;270(5 pt 1):G778-G782. 

3. Gershon MD. The enteric nervous system: 

a second brain. Hosp Pract (Minneap). 

1999;34(7):31-32, 35-38, 41-42 passim. 

4. Törnblom H, Lindberg G, Nyberg B, Veress 

B. Full-thickness biopsy of the jejunum 

reveals inflammation and enteric neuropathy 

in irritable bowel syndrome. Gastroenterology. 

2002;123(6):1972-1979. 

5. Taché Y. Stress and irritable bowel syndrome: 

unravelling the code. International Foundation 

for Gastrointestinal Disorders Web 

site. http://www.iffgd.org/store/viewproduct/211. 

Accessed July 14, 2009. 

6. Singh RK, Pandey HP, Singh RH. Correlation 

of serotonin and monoamine oxidase 

levels with anxiety level in diarrhea-predominant 

irritable bowel syndrome. Indian J Gastroenterol. 

2003;22(3):88-90. 

7. Tollefson GD, Luxenberg M, Valentine R, 

Dunsmore G, Tollefson SL. An open label trial 

of alprazolam in comorbid irritable bowel 

syndrome and generalized anxiety disorder. 

J Clin Psychiatry. 1991;52(12):502-508. 

8. Leventer SM, Raudibaugh K, Frissora CL, et 

al. Clinical trial: dextofisopam in the treatment 

of patients with diarrhoea-predominant 

or alternating irritable bowel syndrome. Aliment 

Pharmacol Ther. 2008;27(2):197-206. 

9. Ritchie JA, Truelove SC. Treatment of irritable 

bowel syndrome with lorazepam, hyoscine 

butylbromide, and ispaghula husk. Br 

Med J. 1979;1(6160):376-378. 

10. Sanger GJ. 5-Hydroxytryptamine and the 

gastrointestinal tract: where next? Trends 

Pharmacol Sci. 2008;29(9):465-471. 

11. van den Meerschaut L, Sünder A. The homeopathic 

preparation Nervoheel N can offer 

an alternative to lorazepam therapy for mild 

nervous disorders. Evid Based Complement 

Alternat Med. Published October 25, 2007. 

doi:10.1093/ecam/nem144. 

12. Müller-Krampe B, Oberbaum M, Klein P, 

Weiser M. Effects of Spascupreel versus hyoscine 

butylbromide for gastrointestinal cramps 

in children. Pediatr Int. 2007;49(3):328-334. 

13. Cappell H, Busto U, Kay G, Naranjo CA, 

Sellers EM, Sanchez-Craig M. Drug deprivation 

and reinforcement by diazepam in a 

dependent population. Psychopharmacology 

(Berl). 1987;91(2):154-160. 

Enteric nervous system 

Figure 1: Stress alters the function 

of the gastrointestinal tract via the 

Intestines 

brain-gut axis. 

Smooth muscle 

Journal of Biomedical Therapy 2009 ) Vol. 3, No. 1 

) 19

) M a r k e t i n g Yo u r P r a c t i c e 

Communication in Your Practice 

By Marc Deschler 

Marketing specialist 

) 20 

An American study shows that faulty communication is 

management’s biggest problem. As a physician, you probably 

spend 90 percent of your working time communicating, 

both consciously and unconsciously. In the long term, 

miscommunication that leads to actual misunderstandings 

can put your practice at risk. 

Review the requirements of 

good communication and make 

improvements as needed: 

1. Good communicators are made, 

not born. Every day brings new 

opportunities to practice and refine 

this ability. 

2. We communicate even when 

we’re not saying anything. For 

example, if you keep your eyes 

fixed on the patient’s chart, 

you’re giving him the (mistaken) 

impression you are not really interested 

in his problem – his most 

important problem, otherwise he 

wouldn’t be there! Pay careful 

attention not only to what you 

say, but also to what you do. 

3. Most of the information that gets 

stored in the brain is received 

through visual channels, and you 

can take advantage of this fact by 

using written information to 

supplement your words. Informational 

materials give patients 

a second chance – if they didn’t 

understand something completely, 

they can read about it later. 

An additional tip: To reinforce 

your competence in your patients’ 

minds, print all informational 

materials on your own letterhead. 

4. Assume that anything you’re trying 

to say can always be misunderstood. 

This will lead to better 

communication on your part, 

since you will choose your words 

differently and observe reactions 

more closely. 

5. Not everything you say has to be 

print-ready and error-free. It’s 

more important that your patients 

understand what you’re 

saying. Avoid pretentious technical 

jargon. 

6. Defining an illness is no help to 

the patient. She wants to know 

what it means for her, and she 

needs to be able to interpret your 

message correctly. 

7. It’s not what you say, but how 

you say it. Pay attention to how 

you say something and to how 

you reinforce it with body language 

because nonverbal communication 

is by far the most 

important contributing factor. 

8. On the phone, nonverbal communication 

is eliminated, so you 

and your team should make a 

special effort to use visual imagery 

when you speak. 

Repeatedly monitor the communication 

behavior of your staff and offer 

training and suggestions for improvements 

as needed. 


A clear structure, whether in 

communication, documentation, or 

filing, will save you time and money. 

The answering machine 

No one likes talking to a machine. 

Not surprisingly, according to one 

study, almost 60 percent of callers 

hang up when they get a machine, 

and of those who do leave a message, 

only 16 percent are identifiable. 

Clearly, though, your answering 

machine is one of the most 

important advertisements for your 

practice. What do you need to keep 

in mind when recording your message? 

1. Include your name in your greeting. 

For example, “Hello, this is 

John Sample at XYZ practice.” 

2. Meet the caller halfway: “Thank 

you for calling. Even though we 

can’t answer the phone right 

now, we’re still here for you.” 

3. Suggest an action: “Please don’t 

hang up, but …” 

4. In closing, thank them again for 

calling. 

Your phone message should be wellprepared, 

not just an afterthought. 

Write out an appropriate text and 

read it in a clear and friendly voice, 

quietly and not too slowly. Your message 

should flow, so concentrate on 

what you’re saying but don’t rush it. 

Check your machine now and then 

by calling yourself. Your voice will 

sound different over the phone than 

it does when you’re recording. The 

tapes in analog machines eventually 

wear out; replace them periodically. 

To make sure you get the information 

you need from your callers, try 

handing out cards to your patients 

with the most important “W” questions 

you need in order to return 

their calls: 

• Who is calling? (name) 

• What are you calling about? 

• Where can you be reached? 

(phone number? E-mail address?) 

• When is a good time to reach 

you? 

Even if you choose not to offer patients 

the option of leaving a message, 

your recorded statement should 

be appropriate and convincing and 

leave them with a professional impression 

of your practice. 

Optimizing record-keeping 

It’s always worth looking for opportunities 

to improve the organization 

of your practice, including patient 

chart management, which can be a 

half-time job in itself if poorly designed. 

To avoid unnecessary expense 

to your practice, follow these 

rules for chart management: 

1. The fewer files you have, the 

faster you can find any individual 

chart. Make sure to keep all of 

each patient’s information together 

in one place! 

2. Sort through the files regularly. 

Inactive folders simply slow 

down your search. 

3. Alphabetization is almost always 

the best filing system. Using as 

many index cards/tabs as possible 

makes it easier to find what 

you need quickly. 

4. Re-file charts as soon as possible 

after adding to them. Don’t leave 

them lying around for someone 

to deal with later. 

5. Formats and labeling should be 

kept consistent so you know 

where to look for what you need 

without searching. 

6. More than three identifying characters 

(first and second letter of 

last name, first letter of first 

name) get unwieldy. Color coding 

(for example, for year of 

treat ment) can speed up access. 

7. File tabs or insert cards should 

be used to indicate status. 

8. Documentation should be completed 

immediately after a service 

is rendered. Here, too, a 

well-conceived and consistent 

structure is important. 

9. For preparing patient charts, 

you’ll need a date stamp, a stamp 

for diagnostic reports, etc. Charts 

prepared for house calls must 

also include a blank prescription 

form. 

10. A quick glance before re-filing 

the chart should be enough to 

ensure that all necessary entries 

have been made. 

If you have the equipment and technical 

know-how, by all means get rid 

of paper charts a.s.a.p. You will eliminate 

a lot of administrative work, 

and that expensive EDP system will 

finally pay for itself ! In many cases, 

the improved work flow even makes 

additional investment in new EDP 

work stations worthwhile.| 

) 21 


) Specialized Applications 

The Acupuncture Approach to the 

Hypothalamus-Pituitary-Adrenal Axis 

and Its Interaction With the 

Sympathetic and Parasympathetic Systems 

By Butch Levy, MD, LAc 

) 22 

In contemplating this article, I was struck by the opportunity 

to connect and integrate an approach to a Western 

anatomical/physiological concept while reflecting on the 

use of Chinese medicine and homotoxicology. The sympathetic/parasympathetic 

system, or autonomic nervous 

system (ANS), can be translated into paradigms of activity 

and interaction using the Oriental construct of acupuncture 

tsubos, or holes, and using homeopathic combinations as 

therapeutic interventions. This combined usage is called 

homeosiniatry*. 

In the US perception of acupuncture, 

points reflect an anatomical 

location where a needle is inserted. 

Changing the rotation of the needle 

infers a method of enhancing or diminishing 

its effect (i.e., clockwise is 

tonification and counterclockwise is 

sedation). 

The Japanese approach to needling 

technique views acupuncture locations 

as specific holes. The needle is 

inserted along a vector, with a direction 

and depth. This requires palpatory 

acumen that translates into a 

precise connection into the path of 

flow desired. 

The extracellular matrix (ECM) is 

the common conduit for therapy, be 

it physiological stimulation of the 

nervous system, the Yin and Yang 

energies of Asian medicine, or the 

electrical signature of natural molecules, 

as is seen in homeopathy. 1 

Within the ECM lie the biological 

features that allow nerve impulses to 

signal and transmit information for 

homeostasis. Layered on that, the 

similar concepts of Yin and Yang 

theory are reflected within the same 

ECM, with cylindrical spirals of 

acupuncture holes acting as a transit 

system, via the meridian system, for 

similar information transmission 

concerning the body’s balance. 2 

Within the Oriental system, the 

ECM represents an equivalent concept, 

expressed as the Triple Heater. 

It is said to convey the Qi that is essential 

in energy transformation and 

metabolism. It is considered to be 

the fluid interface surrounding cells; 

in modern interpretation, it is considered 

to be the extracellular environment 

of the cell. 

The importance of these statements 

is to act as the starting point to treating 

patients with problems of the 

sympathetic/parasympathetic system, 

by being able to act in creative 

ways based on the practitioner’s assessment 

of the patient. It is often 

the situation that a single paradigm 

of therapy is inadequate to treat the 

complexity of issues generated within 

the body. This certainly is true 

regarding the sympathetic/parasympathetic 

system influences within 

us. To integrate these unique therapies 

requires a brief review of the 

connections that make them compatible 

for the treatment of sympathetic/parasympathetic, 

or ANS, 

imbalance. 

Autonomic nervous system 

The aspect of the nervous system 

that is involved in our discussion is 

the ANS. Originating in the hypothalamus, 

fiber tracts from the various 

nuclei (e.g., medial, lateral, anterior) 

travel from the hypothalamus 

into the intermediate brain and 

through the lower brain, making 

connections with multiple other nuclei 

there before descending into the 

spinal cord. These other nuclei also 

contribute essential information for 

ANS regulation. These pathways are 

called the hypothalamospinal tract 

* “Homeo” from homeopathy, “sin” from sinology = study of Chinese culture, and “-iatry” from Greek iatros = healer (figuratively: medicine) 



Acupuncture needles are inserted 

into specific points on the body in 

order to relieve pain and/or restore 

health and well-being. 

© iStockphoto.com/Wolfgang Amri 

(HST) and carry information that 

activates, stimulates, inhibits, or balances 

sympathetic and parasympathetic 

signals. The sympathetic system 

dominates during activity in the 

body and is energy consuming. The 

parasympathetic system dominates 

when the organism is in resting 

phases, including digestion and 

sleep cycles. 

The sympathetic nervous system is 

under the direct control of corticotrophin-releasing 

hormone (CRH) 

in the hypothalamus. Its stimulation 

creates an excitatory response in the 

sympathetic system while turning 

off parasympathetic responses, in 

preparation for the fight, fright, or 

flight response. Some of the direct 

effects seen via increased norepinephrine 

(adrenaline) are stimulation 

of cardiac muscle, an increase in 

heart rate and breathing, an increase 

in blood glucose, sweating, and vasoconstriction. 

At the same time, 

blood volume is expanded via the 

CRH activation of the renin-angiotensin-aldosterone 

system. When 

situations of perceived threat occur, 

anticipatory readiness is also reflected 

in increased muscle activity and 

visual acoustic startle, reduced appetite, 

and an inherent protective anxiety 

to “get out of town” or leave the 

scene quickly. To assist these preparations, 

the visceral tissues become 

quiescent, until the danger has 

passed. 

The spinal parasympathetic system 

is composed of the cranial division 

(cranial nerves III, VII, IX, and X) 

and the sacral division (S2-S4). 

These cranial nerves interconnect 

with the HST fibers via their nuclei, 

located in the midbrain, pons, and 

brainstem. The principal HST parasympathetic 

functions include pupillary 

and lens adjustments, salivation, 

heart rate, movement and 

secretions in the gastrointestinal 

tract, urination, defecation, and erection. 

Specifically, cranial nerve IX 

influences the carotid body and sinus 

and the pharyngeal mucosa. 

Cranial nerve X is related to the larynx 

and trachea and the thoracoabdominal 

viscera to the level of the 

splenic flexure. The sacral plexus involves 

the colon distal to the splenic 

flexure, the rectum, and the bladder. 

The HST of the sympathetic system 

extends from T1 to L2/3. The fibers 

exit the spinal cord as preganglionic 

fibers that release acetylcholine, 

which innervates their nearby 

preaortic and paravertebral postganglionic 

receptors, which then release 

norepinephrine. These chemical 

transmitters then affect the pupils, 

sweat glands, blood vessels, lungs, 

abdominal viscera, and gastrointestinal 

tract. The ANS helps coordinate 

and regulate stimuli coming 

from the external and internal environment. 

Asian medicine 

The seemingly opposite parts of the 

ANS imply energies of mutual dependence 

when considered within 

the paradigm of Asian medicine. It 

is the Yin and Yang that are considered 

as the framework of movement 

and stillness, night and day, light 

and dark, with each aspect requiring 

a comparison to its counterpart to 

make sense. Although the final step 

for our consideration of homeosiniatry 

is specific injection of tsubos, or 

holes, there are essential constructs 

in Asian practice that themselves can 

act to create an enhancement of energy 

or the opposite effect of reducing 

or dampening energetic effects. 

The movement of energy, or Qi, is 

considered to travel unidirectional 

under normal circumstances, along 

each specific meridian pathway. 

Needling a tsubo along this direction 

of flow is considered tonifying 

or sympathetically stimulating. Needling 

techniques that are in the direction 

opposite or counter to established 

meridian flow will slow or 

reduce the energy flow, are considered 

sedating or quieting to the system, 

and would be considered parasympathetic. 

In protocols using electrical stimulation, 

a sympathetic or parasympathetic 

effect can be created via the 

circuits used. Electrical charge travels 

from negative (silver needle or 

black grip) to positive (gold needle 

or red grip), and electrical flows can 

be used to augment or diminish energy 

solely by adjusting the direction 

of flow of the electricity. Practitioners 

can also influence the 

activation of sympathetic activity by 

) 23 



Figure 1: Back Shu points used in 

treating disorders of the hypothalamus-pituitary-adrenal–sympathetic/ 

parasympathetic system. 

low-frequency electrical stimulation 

in the range of 2 to 10 Hz. These 

frequencies are used, for example, in 

facial nerve palsies and for historic 

treatments that were designed to upregulate, 

so to speak, weak energy 

systems within the body. To create a 

parasympathetic flow, high-frequency 

electrical stimulation can be used, 

ranging from 100 to 200 Hz for local 

myofascial injury to 1500 Hz for 

sedation of the central nervous system, 

thereby affecting higher brain 

centers for pain regulation (and a 

down-regulation of pain). 

BL 13 Lung 

BL 14 Pericardium 

BL 15 Heart 

BL 16 Governing vessel 

BL 17 Conception vessel 

BL 18 Liver 

BL 19 Gall bladder 

BL 20 Spleen 

) 24 

Injection sites 

The classic choices for acupuncture 

holes that may be integrated to synergistically 

relate to homeosiniatry 

might include the 8 extra vessels, 

back Shu points (Figure 1), and 

source and auricular points. The extra 

vessel meridians of Yin/Yang 

Wei (Pericardium 6 and Triple Heater 

5) connect and distribute all the 

Yin and Yang, respectively. The Yin/ 

Yang Qiao vessels (Kidney 6 and 

Urinary Bladder 62) balance all the 

Yin and Yang for muscle coordination 

in the body. Also, the Du Mai 

channel, the source of all Yang Qi, 

or sympathetic energy, can be augmented 

by needling from the lower 

spine up and can be quieted or sedated 

by needling from the scalp 

down. For the sympathetic concept, 

this would mean increasing the 

movement in the Yang organs; for 

the parasympathetic concept, the Qi 

energy would be augmented in the 

Yin organs. 

The use of auricular points adds an 

essential synergism for balance 

within the brain and ANS. Using a 

point locator allows exact locations 

for treatment. Traditional interpretations 

used to imply that when one 

BL 21 Stomach 

BL 22 Triple heater 

BL 23 Kidney 

BL 25 Large intestine 

BL 27 Small intestine 

aspect of the ANS was on, the other 

was off, and vice versa. Our society 

today creates levels of continuing 

stressors, and often the continued 

pressure on both aspects of the ANS 

results in imbalances that do not fit 

conventional rules. Using such a 

testing device, areas such as the pi- 



In homeosiniatry, bioregulatory 

medications are injected into 

acupuncture points. 

© iStockphoto.com 

tuitary, hypothalamus, preganglionic 

and postganglionic nerves, vagus, 

parasympathetic nerves, and amygdala 

can be accessed and therapeutically 

used. 

The back Shu points represent a 

level of interaction that would be 

used to affect the individual organs 

that are influenced by the hypothalamus-pituitary-adrenal–sympathetic/parasympathetic 

system. The first 

line relates to organ dysfunction, 

whereas the second line has great 

benefits in emotional issues that affect 

its adjacent organ. 

Practical application 

Some practical examples of homeosiniatry 

that have application in the 

clinic would include the following. 

Starting at the hypothalamus, it 

would be ideal to directly affect its 

function! Tonsilla compositum contains 

hypothalamus and can act toward 

directly targeting at the hypothalamic 

level. Its effect would, 

therefore, generalize to the entire 

system. Points of injection should 

be ones that have general regulatory 

ability, such as Stomach 36 or Spleen 

6. More often, therapy must be designed 

to indirectly affect the system, 

at the feedback loop to the hypothalamus 

or at the organ itself. 

Because hypothalamic CRH controls 

the production of cortisol, the 

negative feedback loop to CRH 

is activated when the hypothalamus 

senses increased cortisol. Therefore, 

using medications that contain 

cortisol will reduce the production 

of CRH and slow or regulate the 

fight or flight response (i.e., sympathetic 

outflow). Tonsilla compositum 

(for overall immune stimulation), 

Thyreoidea compositum (for 

connective tissue metabolism), and 

Pulsatilla compositum (for support 

during chronic inflammation) all 

contain cortisone in dilution and 

can be used to reduce the output of 

CRH and with it sympathetic activity. 

Major organs that are activated by 

sympathetic stimulation are the 

heart, lungs, and the associated circulatory 

system. To affect these organs, 

especially in chronic conditions, 

the back Shu points can be 

injected. Because fight or flight is an 

excess condition, the points chosen 

on the Urinary Bladder line (Urinary 

Bladder 14, Pericardium; and Urinary 

Bladder 15, Heart) are tight 

and tense, indicating overactivity. 

Chronic myocardial weakness or 

coronary circulatory problems can 

be treated with Cactus compositum. 

Cor compositum can be used for 

palpitations, and Cralonin can be 

used for chest pains. The lung area, 

Urinary Bladder 13, can receive 

treatment for bronchospasm, using 

Mucosa compositum for wheezing 

and cough, Traumeel for inflammation, 

or Engystol for immune stimulation. 

In contrast, when sympathetic activation 

is quieted down, ideally the 

parasympathetic system is activated. 

Their innervations primarily involve 

smooth muscle contraction and 

movement within many hollow organs. 

The Master Point of the Yin 

Qiao, Kidney 6, is considered regulatory 

of the Vagus, and Atropinum 

compositum is very useful for cramping 

and imbalanced peristalsis. Point 

choices might also include the 

source points or back Shu points for 

the large and small intestines, the 

spleen and stomach, and the urinary 

bladder and gallbladder. Spascupreel 

is effective for intestinal cramps and 

bladder spasm and irritability. 

In conclusion, any discussion regarding 

the hypothalamus-pituitary-adrenal–ANS 

really requires 

chapters to credibly explain each of 

the topics mentioned in this brief 

discussion. What I have attempted 

to relate is that the complexity of 

disease and our rapidly expanding 

technology have created a need to 

look beyond individual areas of 

focus and embrace a new holism 

of care. It is necessary to integrate 

multiple disciplines, concepts, and 

images to achieve results that succeed. 

| 

References 

1. Oschman J. Energy Medicine. Dover, NH: 

Churchill Livingstone; 2008:141. 

2. Pischinger A. The Extracellular Matrix and 

Ground Regulation. Berkeley, CA: North Atlantic 

Books; 2007:106. 

) 25 


) Making of … 

Manufacturing of 

Traumeel Injection Solution 

Part I: From Work Preparation to Filling 

By Larissa Wörthwein-Mack 

) 26 

To minimize the risk of contamination with microorganisms, 

special requirements apply to the manufacture of 

sterile medications. The standards are high, both for spatial 

and technical conditions and for employee qualifications. 

For example, manufacturing must take place in so-called 

cleanrooms of the appropriate classes, and spatial separation 

of the different production steps is required. 

Modern homeopathic combination 

products like Traumeel 

(which is used to treat inflammation 

and injuries) contain multiple ingredients. 

In Traumeel injection solution, 

there are 14 different active 

in gredients, primarily plant substances 

such as arnica, chamomile, 

and calendula. These raw materials 

are processed into mother tinctures 

and single potencies in accordance 

with current regulations of the German 

Homeopathic Pharmacopeia 

(HAB) and the European Pharmacopeia 

(Ph. Eur.). 

Production of a sterile 

dosage form 

All manufacturing steps involving 

open containers must take place in 

Class C cleanrooms, which can be 

accessed only through airlocks and 

in appropriate protective clothing. 

High performance filters reduce the 

particulate count in the air, and the 

rooms are under positive pressure 

with more than 20 air exchanges 

per hour. Pressure differentials of 

10-15 Pa between cleanrooms of 

different classes ensure that when 

the door of a cleaner room is opened, 

the air streams out and contaminated 

air cannot flow in. The air is tested 

at regular intervals for particulate 

counts and microbiological loads. 

All exposed surfaces in the cleanrooms 

must be smooth and easy to 

clean. The special requirements that 

apply to employees engaged in manufacturing 

sterile products include 

regular training in sterile manufacturing, 

hygiene, and microbiology. 

Of course high standards of personal 

hygiene are also a must, and inside 

the cleanroom, employees are 

not allowed to wear jewelry or 

make-up! Regular medical checkups 

are also required. 

The steps in the production of sterile 

ampoules are: work preparation, 

bulk production, filtration, filling, 

ste ri lization, inspection, labeling, 

and packaging. Each individual production 

step takes place in accordance 

with clearly defined procedures 

and current GMP (Good 

Manufacturing Practice) guidelines. 

Written production instructions for 

each product detail all of the individual 

steps in its production. The 

production instructions are based on 

the company’s manufacturing specifications, 

the CTD-HD (Common 

Technical Document – Manufacturing 

Documentation), which is submitted 

to the regulatory agency. 



Producing potency mixtures from 

individual potencies according to 

manufacturing specifications 

Specially trained employees conduct 

in-process controls (IPC) at regular 

intervals during production. These 

controls serve to monitor and direct 

the production process, ensuring 

high quality and compliance with 

all requirements at every stage of 

processing. 

The production process 

The first step takes place in the Work 

Preparation department, where 

batch-specific production instructions 

are drawn up. In these documents, 

employees will record every 

detail of the processes involved in 

producing the batch. 

In the Bulk Production department, 

the 14 active ingredients (mother 

tinctures, single potencies, and triturations) 

are manufactured in accordance 

with the production guide. 

Ethanol-water mixtures in varying 

concentrations are used as the potentizing 

medium. 

The next step is production of the 

so-called bulk solutions. The individual 

potencies and triturations are 

combined into potency mixtures, 

which are then further potentized 

with water for injection. The resulting 

intermediate products are then 

mixed in large stainless steel tanks, 

and a specific amount of sodium 

chloride is added to produce an isotonic 

solution. 

IPC workers take samples of the finished 

bulk solution and test for a 

variety of parameters including pH, 

isotonicity, and appearance. The 

bulk solution is released for further 

processing only if all values fall 

within the required ranges. This step 

Manual potentization of 

a potency mixture 

Stainless steel batching tank for 

producing the solution 

Filtering the bulk solution through 

a sterile membrane 

) 27 



Interim storage of the bulk solution 

in sterile disposable containers 

is followed by bulk filtration, which 

removes suspended matter and reduces 

germs. The filter is a sterile 

membrane filter with a pore size of 

0.22 µm. The filtered solution is 

filled into sterile, flexible, disposable 

containers. 

The used filter is then tested for integrity, 

and if it passes the test, the 

filtered batch of bulk solution is 

transported to the filling equipment 

in disposable containers with capacities 

ranging from 10 to 50 liters. 

The containers are connected to the 

filling equipment, and the required 

quantities of glass ampoules are prepared. 

Before the actual filling takes 

place, a test run of a certain number 

of ampoules is filled to check for accuracy 

of the fill quantity. 

If the fill quantities match the target 

value, the machine is cleared for filling. 

Precisely measured fill quantities 

are then pumped into the sterile 

glass ampoules through six filling 

nozzles. Finally, a blowpipe is used 

to seal the open ampoules by melting 

their necks to create a closure. 

Each machine can fill up to 18,000 

ampoules per hour. 

In the next issue, you will learn 

about the further steps required to 

produce a finished, customer-ready 

product.| 

) 28 

Filling and heat sealing the sterile glass 

ampoules 

Photos by Sonja Bell 


) Meet the Expert 

Dr. Arturo O’Byrne 

By Catherine E. Creeger 

Arturo O’Byrne was born in 

1951 in Cali, Colombia, into a 

long line of medical doctors. He received 

his first practical instruction 

in surgery from his father in their 

family-owned clinic. 

Young Arturo was very interested in 

photography and designing educational 

materials, and in college he 

collaborated with many of his professors 

on audiovisual presentations 

for classes. This skill in developing 

innovative educational tools would 

later become one of the foundations 

of his professional activities. He 

graduated from the Universidad del 

Cauca in Popayán, Colombia in 

1976 with a diploma in surgery. 

During his student years, the climate 

in Popayán aggravated the asthma 

he had suffered from since childhood. 

His search for better health 

led him to the Colombian physician 

Dr. Germán Duque, who pioneered 

biological medicine in South America. 

Duque’s treatments produced a 

lasting cure within a few months. 

This introduction to alternative 

therapeutic methods, including homeopathy 

and homotoxicology, 

marked a radical and irrevocable 

turning point in Dr. O’Byrne’s life. 

On Duque’s advice, Dr. O’Byrne 

travelled to Europe to learn about 

integrative biological medicine firsthand. 

(Later, as medical director of 

Santa Margarita Hospital in La 

Cumbre, he would become the first 

to obtain authorization for a pilot 

program in biological medicine in a 

National Health Service hospital.) 

Back in Colombia, he studied sports 

medicine and nutrition in Cali, 

where he later also held professorships 

in biology and physiology. 

From 1987 to 1989, as medical director 

of the professional cycling 

team “Café de Colombia,” he based 

the athletes’ training and maintenance 

program on biological medicine. 

During this time, the team 

achieved international standing in 

particular in mountain racing, resulting 

in first places in the 1987 

Vuelta a España and the 1988 Dauphiné 

Libéré and a third place in the 

1988 Tour de France. His work with 

other sports teams had similar results 

and generated considerable interest 

in biological therapies in 

sports medicine in Colombia. 

In 1989, Dr. O’Byrne founded the 

teaching hospital “Centro de Medicina 

Biológica Dr. O’Byrne” in 

Cali and began giving courses and 

talks for doctors. Since then, his ongoing 

efforts in disseminating homotoxicology 

and biological medicine 

have led him to travel widely, 

especially in Latin America. Over 

the course of seventeen years, he has 

logged more than four million flight 

miles and given more than 650 seminars! 

Throughout this time, he has remained 

dedicated to producing 

state-of-the-art educational material. 

In 2007, with his son Daniel, he 

founded BioMD-SA, an academic 

services center focusing on professional 

production of high-definition 

3D animation, medical illustration, 

etc. His home workstation has three 

LCD screens (internet, PowerPoint, 

and Photoshop) in use simultaneously. 

For entertainment on his long 

trips, he downloads music of all 

genres to his I-pod. (The airlines 

serve vanilla ice cream with Baileys 

Irish Cream, which also helps to 

pass the time!) Dr. O’Byrne enjoys 

playing guitar at family gatherings 

and is a natural at salsa dancing, but 

he is always eager to get back to his 

medical projects as soon as the festivities 

are over. This is the mark of 

a true scientist!| 

) 29 


) Research Highlights 

Nervoheel N vs. Lorazepam for 

Mild Nervous Disorders 

By Mary A. Kingzette 

) 30 

Introduction 

Complementary and alternative 

medicine (CAM) is being used more 

often, both in Europe and in the 

United States. One of the main reasons 

for the increase in CAM is the 

adverse effects seen with conventional 

medications, leading to the 

withdrawal of some of these drugs 

from the market. It is believed that 

CAM medications are better tolerated 

than conventional medications. 

One of the frequent uses of CAM is 

for treatment of functional nervous 

disorders, including insomnia, distress, 

anxiety, restlessness, and burnout. 

In this study, Nervoheel N, a 

CAM medication, was compared 

with lorazepam, a conventional benzodiazepine, 

for the treatment of 

functional nervous disorders. Specifically, 

the effectiveness and tolerability 

of the 2 medications were 

compared. The purpose of the study 

was to show the noninferiority of 

Nervoheel N vs. lorazepam. 

Nervoheel N is a preparation based 

on the principles of homotoxicology. 

Lorazepam has a relatively short 

half-life and is favored over longacting 

benzodiazepines for the 

short-term relief of anxiety. Benzodiazepines 

are contraindicated for 

long-term use because of their addictiveness 

and adverse effects. 

The present study was a preliminary 

open-label prospective nonrandomized 

cohort investigation. To our 

knowledge, it is the first study to 

evaluate the effectiveness of Nervoheel 

N in a clinical setting. 

Methods 

This study was performed in 39 

centers in Belgium and the Netherlands; 

these centers offer both conventional 

and CAM therapy. Patients 

enrolled were18 years or older and 

suffered from headache, heart palpitations, 

backache, indigestion, lack 

of appetite, mild sexual dysfunction, 

fatigue, listlessness, sleep disturbances, 

restlessness, or lack of concentration. 

Patients excluded were 

those who were unable or did not 

want to participate in the study and 

those taking both Nervoheel N and 

lorazepam. 

The study duration was a maximum 

of 4 weeks. Patients were examined 

at the start of treatment, after 2 

weeks of treatment, and after 4 

weeks of treatment. 

Physicians decided the treatment 

used for each patient (after discussion 

with the patient), and any other 

medications taken were not changed 

during the study. The dose of Nervoheel 

N given was 1 tablet 3 times 

a day; the dose of lorazepam given 

was 2 to 3 mg daily for sedation and 

anxiety and 2 to 4 mg nightly for 

insomnia. Variations in the dose 

were allowed if determined to be in 

the patient’s best interest. 

The effects of treatment were determined 

in conversation between the 

practitioner and the patient. The severity 

of symptoms was evaluated 

on a 4-point scale (0 indicates 

asymptomatic; 1, mild; 2, moderate; 

and 3, severe). The overall effect of 

the therapies was evaluated on a 

5-point scale (excellent, good, satisfactory, 

no improvement, and worsening 

of symptoms). Tolerability 

was determined by patient-reported 

adverse events evaluated by the physician. 

Overall tolerability of the 

treatments was evaluated as excellent, 

good, moderate, or poor. 

Results 

A total of 248 patients were included 

in this study (136 in the Nervoheel 

N group and 112 in the lorazepam 

group). After 2 weeks of 

treatment, 128 patients in the Nervoheel 

N group and 106 patients in 

the lorazepam group were examined. 

At the final 4-week examination, 

the numbers of patients included 

were 134 and 111, respectively. 

There were several differences between 

the 2 groups at enrollment: 

Patients in the lorazepam group 

were older and were more likely to 

be men, to smoke, and to use alcohol 

or coffee regularly than patients 

in the Nervoheel N group. However, 

none of these differences were statistically 

significant. 

There was also no significant difference 

in the number of nervous disorders 

between the 2 groups (predominately 

2-4 disorders). In both 

groups, the most common com- 


) Research Highlights 

Sepia, one of the ingredients of 

Nervoheel N, is prepared from the 

secretion of the inkgland of the 

cuttlefish (Sepia officinalis). 

© cherie/Fotolia.de 

plaints included emotional distress, 

jitteriness, and anxiety; and the most 

common reasons given for the complaints 

included work-related anxiety, 

stress, and family-related anxiety. 

Most patients in both groups 

(> 70%) had not received previous 

treatment for their condition. 

In both groups, there were significant 

differences from baseline: The 

sum of symptom scores improved by 

4.4 points in the Nervoheel N group 

and by 4.2 points in the lorazepam 

group. However, there was not a 

significant difference between the 

2 groups. 

For both groups, the greatest symptom 

improvement was seen at the 

2-week examination, with slight 

continued improvement until the 

4-week examination. Even though 

most patients chose to maintain 

treatment for longer than 4 weeks, 

less than 10% did so for longer than 

6 weeks. The average duration of 

treatment was 31 days in the Nervoheel 

N group and 29 days in the 

lorazepam group. 

There was no significant difference 

between the 2 groups in overall 

therapeutic results (rated as excellent 

to good by 72.1% of the Nervoheel 

N group and 73.7% of the lorazepam 

group; P = 0.84). 

The tolerability of both treatments 

was very good, with only one patient 

in each group experiencing an 

adverse event (both considered unlikely 

to be treatment related). 

Notably, the overall patient-assessed 

tolerability was significantly better 

for the Nervoheel N group vs. the 

lorazepam group: Tolerability was 

rated as excellent in 81.9% vs. 45.5% 

of patients (P < 0.001). 

There was no significant difference 

between the 2 groups in compliance 

scores (P = 0.35), with compliance 

ratings of excellent or good for approximately 

90% of both groups. 

Discussion 

This study showed that Nervoheel 

N, a homotoxicological medication, 

can effectively treat mild nervous 

disorders, including aches, palpitations, 

indigestion, lack of appetite, 

mild sexual dysfunction, fatigue, 

listlessness, sleep disturbances, restlessness, 

and lack of concentration. 

The study indicated that Nervoheel 

N was better tolerated than lorazepam, 

a traditional benzodiazepine 

medication used to treat these disorders. 

This being an open-label observational 

trial, there are limitations to 

such a study that are inherent in the 

design. First, the enrollment criteria 

for mild nervous disorders are somewhat 

subjective because there are no 

standardized rating scales for these 

disorders. 

Second, the evaluations were left 

mostly to the physician’s discretion, 

which could result in greater physician 

bias. However, the fact that the 

enrolling centers offer both complementary 

and conventional medicine 

may reduce this factor in this case. 

Third, baseline differences between 

groups are inherent in the design of 

observational studies, as was also 

found in the present study. 

There were also other differences 

between the 2 treatment groups 

(older patients and more male patients, 

with different lifestyle habits, 

in the lorazepam group), which were 

addressed with propensity score 

analysis but would not exclude all 

bias. 

However, the strength of observational 

studies is not so much to show 

efficacy, but to show effectiveness in 

a practice-based setting and to demonstrate 

tolerability, in which this 

study succeeded. 

In conclusion, this 4-week study 

showed that Nervoheel N (a homeopathic 

treatment) was not inferior 

to lorazepam (a conventional benzo 

diazepine treatment) for the 

short-term relief of mild nervous 

symptoms. In addition, significantly 

more patients rated the tolerability 

of Nervoheel N as excellent compared 

with the tolerability of lorazepam. 

| 

Reference 

van den Meerschaut L, Sünder A. The homeopathic 

preparation Nervoheel N can offer an alternative 

to lorazepam therapy for mild nervous 

disorders. Evid Based Complement Alternat Med. 

Published October 25, 2007. doi:10.1093/ 

ecam/nem144. 

) 31 


IAH Abbreviated 

Course 

An e-learning course leading to 

certification in homotoxicology 

from the International Academy for 

Homotoxicology in just 40 hours. 

1 Access the IAH website at www.iah-online.com. 

Select your language. 

2 Click on Login and register. 

3 Go to Education Program. 

4 Click on The IAH abbreviated course. 

5 When you have finished the course, click on Examination. 

After completing it successfully, you will receive your 

certificate by mail. 

For MDs and licensed healthcare practitioners only 

Free of charge 

) 32 

www.iah-online.com

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