BIBLIOGRAPHIC INPUT SHEET TEMPORARY Patterns of mortality ...

Chapter X. Congenital Anomalies
215
CONGENITAL ANOMALIES OF OTHER SYSTEMS
Anomalies of the respiratory system were
found in 71 deceased infants in 15 l)rojects
combined (Table 103). In 14 of these (lentils
the anomalies were unrelated to the process
of death. In tile California project, in 23
out of tie 26 infant deaths due to these
conditions they acted as underlying or assoeiated
causes, Illost of the deatis (20)
being due to Ipulmonary hypoplasia Icategory
748.6).
All eight anomalies of the resp)iratory
system in the Sherbrooke Iprojeet acted as
associated causes, and four of them were
contrii)utorv to allsence of diaphragnl
(756.8k as unlierlying ealus,. Another was
associated with aneneeplhalus as underlying
cause and also with absence of diaphragm
as associated cause. In one death plilllonary
hypoi)lasia was associated witil cystic
fibrosis T273.0 1. Another of these anolmalies
was associated witil renal agenesis an(l tile
last of the eight was associated with (oaretation
of aorta 1747.11 as underlying
cause.
Clubfoot (754) was found in 178 deceased
infants and was unrelated to the process of
death in 175. In the remaining three infants,
a complication of trealtment triggered
the chain of events leading to death. Tile
highest rates for this anomnaly were found
in San .huan Province and in tile Chilean
project, where there were 72.8 and 62.0 leceased
infants with clubfoot per 100,000 live
birth,, respectively.
Among the 370 infant (leatils in which
ol0r anomalies of the museuloskeletal system
such
(755,
conditions
756) were
involved
found,
as
in
underlying
only 109 were
or
associated causes. In 52 of these 109 (lentils
they were underlying causes; 50 belonged
to category 756 and the other two were assigned
to (atgoy 755. The other 57 deesed
infnts had 44 omlieos belonging
to category 756 as assoeinted causes and
only 13 assigned to category 755, also as associated
ealses. Therefore. it seems oxidIlt
that conditions in entegory 7,56 are more
sorioue from tle standpoint of mortality
than those in categories 754 and 755.
MORTALITY BY AGE OF MOTHER
Tile influence of maternal age on anomalies
in the products of gestation is usually
an important factor. In this presentation
tile death rates by maternal age have been
shown for Down's disease and for anolialies
of tile nervous and tile circulatory systems.
Augmented rates were noted with increased
Imaternal age ill )own's disease, whicih ilrobably
raised the rates for anomalies of the
circulatory system owing to tile frequent
association of these two conditions (10.3
per cent of the deceased infants with cirdulatory
anomalies had Down's disease as
well).
In Table 125 the distribution of deceased
infants with congenital anonlalies is given
by age of mother at tile infant's birth. Of
tile total, 32.8 per cent were born to mothers
aged 30 years and over (excluding those
with age unknown). This nereentae is