BIBLIOGRAPHIC INPUT SHEET TEMPORARY Patterns of mortality ...

204 Patternaof Mortalityin Childhood
In the WHO study (Stevenson et al., mothers 45 years of age and over, according
1966) one half of infants with Down's dis- to this study.
ease (176 of 347) were born to mothers 35 The selection of the underlying cause in
years of age and over. In that study the deaths of children with Down's disease was
were very low for infants of mothers at times difficult, particularly in those in
rates
aged 20-29 years, after which they in- which other anomalies such as ostium pricreased-
rapidly, reaching extremely high mum, interventricular septal defect, or duowere
also present. The underlevels
for mothers aged 40 years and over. denal atresia
These rates per 1,000 total single births lying cause was assigned to the congenital
(fetal deaths and live births) were as fol- anomaly most closely related to the terminal
lows:
or direct cause of death. The association
anoma­
35-9 40-44 46 years between Down's disease and other
Less than 16-19 90-24 15-!9 30-34
16years yeors yeor years years yea-, years nrdover lies was frequently found. Such anomalies
0.30 0.50 0.32 0.38 1.63 2.11 6.34 18.65 were not considered as components of the
Thus, the risk becomes very great for older chromosomal abnormality of Down's dismothers;
in fact, as high as 1 in 60 for ease.
115. Additional Anomalies in Association with Down's Disease in Deceased Infants in 15 Pro­
TAIuL
jects.
Projct Project
Additional anomalies
Number
Total with Musculowith
~Down's additional anomalies Circulatory sse Digestive ytm, skeletal ytm Ohr
(7ltn system-., systemgo Ohr
disease (746,747) (754-750)
No. % No. % No. % No. % No. %
Total ................................. 300 148 48.4 99 32.4 44 14.4 10 6.2 30 0.8
ARGENTINA
Chaco Province ...................... 8 -
San Juan Province .................... 14 9
BOLIVIA projeot ...................... 7 2
BRAZIL
Recife ...............................
RibeirSo PrOto .......................
19 11 57.0 8 42.1 1 5.3 1 5.3 3 15.8
14 8 57.1 7 50.0 1 7.1 - - - -
Sao Paulo ........................... 34 14 41.2 7 20.0 3 8.8 3 8.8 4 11.8
CANADA
Sherbrooke ........................... 8 5 # 4 # 2-
- -
CHILE project ....................... 42 10 45.2 14 33.3 8 10.0 2 4.8 2 4.8
COLOMBIA
Call ................................ 10 5 50.0 3 30.0 2 20.0 1 10.0 2 20.0
Cartagena ........................... 20 8 40.0 3 15.0 3 15.0 2 10.0 3 15.0
Medellin ............................. 10 8 42.1 4 21.1 5 26.3 1 5.3 3 15.8
EL SALVADOR project ................. 22 11 50.0 8 30.4 1 4.5 3 13.6 1 4.5
JAMAICA
Kingston-St. Andrew ................. 27 10 59.3 15 55.0 3 11.1 1 3.7 - -
MEXICO
Monterrey ........................... 47 20 42.0 It 23.4 5 10.0 4 8.5 4 8.5
UNITED STATES
California project ..................... 16 12 80.0 8 53.3 5 33.3 1 6.7 4 26.7
Categories 524, 550, 551,749-751.
b More than one anomaly of this system may be included.
V Por cent not calculated for base less titan10.
64.3
#
-
7
50.0
-
3
2
21.4
#
-
-
•-
-
2
2
14.3
#