BIBLIOGRAPHIC INPUT SHEET TEMPORARY Patterns of mortality ...

BIBLIOGRAPHIC INPUT SHEET TEMPORARY Patterns of mortality ... BIBLIOGRAPHIC INPUT SHEET TEMPORARY Patterns of mortality ...

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Chapter I Origin and Initial Phases One of the goals established by the nations of the Hemisphere in the Charter of Punta del Este (1961) was to reduce mortality in children under 5 years of age by one half in a 10-year period. This has proved to be a great challenge in the years since the Charter was signed. The Inter-American Investigation of Mortality in Childhood, a collaborative research project coordinated by the Pan American Health Organization on a continental scale, has provided an excellent mechanism for exploring in depth the causes of excessive mortality in infancy and early childhood in the Americas, as well as the interrelationships of multiple causes and associated factors. The principal findings of this extensive community-centered program, carried out in the period 1968-1972, should serve as the basis for renewed efforts to improve health conditions in a major segment of the population of the countries. The predecessor of this program-the Inter-American Investigation of Mortality (Puffer and Griffith, 1967), conducted in 1962-1964-was planned with one primary objective: to provide a comprehensive account, as accurate and as comparable as possible, of the causes of mortality in adults in highly diverse and widely separated populations. The patterns of mortality were shown to vary widely, and surprising and intriguing differences in the death rates were revealed. In addition to pointing up specific fields for preventive action, the results served to define the needs and opportunities for further epidemiologic research. They indicated clearly that hospital and autopsy records contained additional information which, when combined with the clinical data, made possible more precise definitions of causes of death. Moreover, since the selection of one underlying cause governed by arbitrary rules meant that valuable information was discarded, one of the recommendations was that suitable methods be developed for handling multiple causes and combinations of causes, that is, for discovering etiologically significant associations. Experimentation with modern computer techniques for studying the epidemiology of diseases on the basis of conbinations of pathological states was also recommended. That first collaborative research program was of necessity carried out in urban areas in order to obtain complete information on all deaths, but it was recognized that differences in mortality patterns in rural populations also needed to be investigated. Moreover, while the health problems of adult life are of paramount concern in developed countries, those of infancy and childhood continue to be of primary importance in over half the world's population. And in an era when population pressures

2 Pattern8of Mortality in Childhood are of major interest, planning for healthy and intelligent infants and elimination of biological wastage have especially high priority. Thus the principal collaborators of the first study on adult mortality recommended that a similar investigation of the problems in childhood be undertaken, using as a foundation the experience gained in the first program and implementing the recommendations with respect to study of multipie causes and experimentation with modern computer techniques. In this way, much more ambitious objectives were set for the new continental research program. OBJECTIVES The overall objective of the Investigation was to carry out in selected communities of the Americas research projects designed to establish death rates for infancy and childhood that would be as accurate and comparable as possible, taking into account biological as well as nutritional, sociological, and environmental factors. In order to analyze both underlying and associated causes of death and to study interrelationships of diseases and other conditions, complete data were to be obtained on deaths in children under 5 years of age in accordance with standard definitions and procedures. To relate mortality to biological and other factors, considerable information was required regarding the home, the environment, the parents, practice of breast feeding, and provision of health care. As a basis for evaluating the many factors involved, a specific objective was to study the reproductive history of mothers, ascertaining the relationships of variables such as age of mother, birth order of deceased infant, and previous reproductive wastage. Another was to study and compare biological and social differences in those who die in early life and those who live, through probability sampling of households and of living children under 5 years of age. Because of the known variations in usage of medical terminology and the difficulties that have been encountered in obtaining comparable classifications of causes, one of the objectives was to make an intensive study of assignment and classification problems in order to develop iml)roved procedures for incorporation into the 1975 Revision of the InternationalClassificationof Diseases of the World Health Organization. This study involved assignments of associated as well as underlying causes. In order to better understand and plan for tile solution of problems in childhood in the Americas , one of the goals was to study mortality in rural as well as urban areas. In keeping with the new emphasis placed by health authorities on strengthening modical research, one of the aims was to stimulate the interest of schools of medicine and public health and involve them in the studies. By setting this series of objectives the Investigation sought to gain fuller knowledge of health problems of the child population and thereby develop solid bases for new approaches and integrated action. The findings reported at this time are from the study of deaths under 5 years of age. Chapters II and III which follow describe the steps taken to include all deaths that occurred and to obtain clinical and other diagnostic information in order to reach the goal of "data as complete and comparable as possible." An overall view

2 Pattern8<strong>of</strong> Mortality in Childhood<br />

are <strong>of</strong> major interest, planning for healthy<br />

and intelligent infants and elimination<br />

<strong>of</strong> biological wastage have especially high<br />

priority. Thus the principal collaborators<br />

<strong>of</strong> the first study on adult <strong>mortality</strong> recommended<br />

that a similar investigation <strong>of</strong> the<br />

problems in childhood be undertaken, using<br />

as a foundation the experience gained in the<br />

first program and implementing the recommendations<br />

with respect to study <strong>of</strong> multipie<br />

causes and experimentation with modern<br />

computer techniques. In this way, much<br />

more ambitious objectives were set for the<br />

new continental research program.<br />

OBJECTIVES<br />

The overall objective <strong>of</strong> the Investigation<br />

was to carry out in selected communities<br />

<strong>of</strong> the Americas research projects designed<br />

to establish death rates for infancy and<br />

childhood that would be as accurate and<br />

comparable as possible, taking into account<br />

biological as well as nutritional, sociological,<br />

and environmental factors. In order to<br />

analyze both underlying and associated<br />

causes <strong>of</strong> death and to study interrelationships<br />

<strong>of</strong> diseases and other conditions, complete<br />

data were to be obtained on deaths<br />

in children under 5 years <strong>of</strong> age in accordance<br />

with standard definitions and procedures.<br />

To relate <strong>mortality</strong> to biological<br />

and other factors, considerable information<br />

was required regarding the home, the environment,<br />

the parents, practice <strong>of</strong> breast<br />

feeding, and provision <strong>of</strong> health care.<br />

As a basis for evaluating the many factors<br />

involved, a specific objective was to<br />

study the reproductive history <strong>of</strong> mothers,<br />

ascertaining the relationships <strong>of</strong> variables<br />

such as age <strong>of</strong> mother, birth order <strong>of</strong> deceased<br />

infant, and previous reproductive<br />

wastage. Another was to study and compare<br />

biological and social differences in<br />

those who die in early life and those who<br />

live, through probability sampling <strong>of</strong> households<br />

and <strong>of</strong> living children under 5 years<br />

<strong>of</strong> age.<br />

Because <strong>of</strong> the known variations in usage<br />

<strong>of</strong> medical terminology and the difficulties<br />

that have been encountered in obtaining<br />

comparable classifications <strong>of</strong> causes, one <strong>of</strong><br />

the objectives was to make an intensive<br />

study <strong>of</strong> assignment and classification problems<br />

in order to develop iml)roved procedures<br />

for incorporation into the 1975 Revision<br />

<strong>of</strong> the InternationalClassification<strong>of</strong><br />

Diseases <strong>of</strong> the World Health Organization.<br />

This study involved assignments <strong>of</strong> associated<br />

as well as underlying causes.<br />

In order to better understand and plan<br />

for tile solution <strong>of</strong> problems in childhood in<br />

the Americas , one <strong>of</strong> the goals was to study<br />

<strong>mortality</strong> in rural as well as urban areas.<br />

In keeping with the new emphasis placed<br />

by health authorities on strengthening modical<br />

research, one <strong>of</strong> the aims was to stimulate<br />

the interest <strong>of</strong> schools <strong>of</strong> medicine and<br />

public health and involve them in the<br />

studies.<br />

By setting this series <strong>of</strong> objectives<br />

the Investigation sought to gain fuller<br />

knowledge <strong>of</strong> health problems <strong>of</strong> the child<br />

population and thereby develop solid bases<br />

for new approaches and integrated action.<br />

The findings reported at this time are from<br />

the study <strong>of</strong> deaths under 5 years <strong>of</strong> age.<br />

Chapters II and III which follow describe<br />

the steps taken to include all deaths<br />

that occurred and to obtain clinical and<br />

other diagnostic information in order to<br />

reach the goal <strong>of</strong> "data as complete and<br />

comparable as possible." An overall view

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