XANTHOMA OF THE BREAST In a series of nine hundred (circa ...

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Downloaded from cancerres.aacrjournals.org on December 28, 2013. © 1932 American Association for Cancer Research. XANTHOMA OF THE BREAST nOI radical mastectomy performed. The section showed "large polyhedral cells apparently lying in alveoli. These cells were not quite like the usual type of carcinoma, being even larger than the unshrunk cells seen in fresh sections; but the appearance was not recognizable as anything else, and the diagnosis was taken to be confirmed." The case of traumatic fat necrosis (Case 6) included in the present study was diagnosed by frozen section. SUMMARY Xanthomas in general have been discussed, and tumors of the breast containing xanthoma cells have been classified as follows: A. Primary xanthoma: a very rare tumor composed wholly of xanthoma cells and arising as a local manifestation of the syndrome of xanthomatosis. B. Secondary xanthomatous degeneration, frequently encountered in (1) true neoplasms, (2) inflammatory processes, and (3) traumatic fat necrosis. Three cases of primary xanthoma of the breast, and illustrative cases of secondary xanthomatous degeneration occurring in fibroadenoma, in chronic breast abscess, and in traumatic fat necrosis in the breast have been described. BIBLIOGRAPHY ARNING, E., AND LIPPMANN, A.: Essentielle Cholesterinamie mit Xanthombildung, Ztschr. f. klin. Med. 89: 107, 1920. ASCHOFF, L.: Pathologische Anatomie, Gustav Fischer, Jena, 1923, Vol. 2, p. 991. BORST, MAX: Allgemeine Pathologic der malignen Geschwlilste, S. Hirzel, Leipzig, 1924, p. 211. BRODERS, A. C.: Benign xanthic extraperiosteal tumor of the extremities containing foreign body giant cells, Ann. Surg. 70: 574, 1919. CHALIPSKY, A. L., AND VEGER, A. M.: Tumorartige Xanthomatosis mit Storungen seitens des endokrinen und des Nerven-Systems, Dermat. VVchnschr. 89: 1972, 1929. CHEATLE, G. L., AND CUTLER, M.: Tumors of the Breast, J. P. Lippincott Co., Philadelphia, 1932, p. 307. CHAUFFARD, 0., AND LAROCHE, G.: Pathogenie du xanthelasma, Semaine med. 30: 241, 1910. CHIARI, H.: Die generalisierte Xanthornatose von Typus Schuller-Christian, Ergebn. d. aUg. Path. und path. Anat. 24: 396, 1931. CHRISTIAN, H. A.: Defects in Membranous Bones, Exophthalmos and Diabetes Insipidus: Contributions to Medical and Biological Research, Paul B. Hoeber & Co., New York, Vol. 1, p. 390, 1919.
Downloaded from cancerres.aacrjournals.org on December 28, 2013. © 1932 American Association for Cancer Research. 1102 CUSHMAN D. HAAGENSEN CORTEN, M. H.: Beitrag zur Histogenese des Xanthoma, Frankfurt. Ztschr. f. Path. 23: 389, 1920. DUBS, IRMGARD: Xanthomzellenbildung in der Uteruschleimhaut bei Funduskarsinom, Centralbl. f. allg. Path. u. path. Anat. 34: 145, 1923. DI ETRICH, A.: nber ein Fibroxanthosarkom mit eigenartiger Ausbreitung und tiber eine Vena cava sup. sinistra bei dem gleichen Fall, Virchow's Arch. f. path. Anat. 212: 119, 1913. EVANS, W.: A case of xanthoma treated by x-rays, Brit. J. Dermat. 14: 465, 1902. FLEISSIG, J.: Uber die blsher als Riesenzellensarkome (Myelorne) bezeichneten Granulationsgeschwulste der Sehnenscheiden, Deutsche Ztschr. f. Chir. 122: 239, 1913. GARRETT, C. A.: Tumors of the xanthoma type, Arch. Surg. 8: 890, 1924. GOTTHEIL, W. S.: Xanthoma tuberosum multiplex, J. Cutan. Dis. 24: 37, 1906. GROSS: Xanthom der Mamma, Deutsche med. Wchnschr. 53: 1117, 1927. HADFIELD, G.: Fat necrosis of the breast, with an account of a case, Brit. J. Surg. 13: 742, 1926. HEDINGER: Fibroadenoma intracanaliculare lipomyxosarcomatodes xanthomatodes mammae bei einer 39 jahrigen Frau, Schweiz. med. Wchnschr. 4: 828, 1923. HUFSCHMITT, G., AND NESSMANN, V.: Xanthomes familiaux, Ann. de dermat. et syph. 1: 462, 1930. HUTCHINSON, J., SANGSTER, A., AND CROCKER, H. R.: Report on cases of xanthoma multiplex brought before the Pathological Society by Mr. James Startin and Dr. Stephen Mackenzie, Trans. Path. Soc. London 33: 376, 1882. HUTTER, KARL: Uber ein Xanthom von ungewohnlichem Sitz und seltener Grosse, Deutsche Ztschr. f. Chir. 201: 416, 1927. KEYNES, G.: A case of fat necrosis of the breast, Brit. J. Surg. 12: 663, 1925. KIRCH, EUGEN: nber Wesen und Entstehung der Xanthomatosen Geschwulste, Klin. Wchnschr, 3: 1425, 1924. LANDOIS, F., AND REID, M.: Das pigmentierte riesenzellenhaltige Xantho Sarkom der Extremitaten, Beitr. z. klin. Chir. 95: 56, 1915. LEE, B. J., AND ADAIR, F. E.: A further report on traumatic fat necrosis of the female breast and its differentiation from carcinoma, Surg. Gynec. & Obst. 34: 521, 1922. LOBECK, E.: Uber Xanthomzellenbildung in pathologisch veranderten Mammae, Arch. f. klin. Chir. 141: 540, 1926. LUBARSCH, 0.: Generalisierte Xanthomatose bei Diabetes, Deutsche med. Wchnschr. 44: 484, 1918. MACKEE, G. M.: X-ray and Radium in the Treatment of Diseases of the Skin, Lea & Febiger, Philadelphia, ed. 2, 1927, p. 665. MACKENZIE, STEPHEN: Two cases of congenital xanthelasma, Trans. Path. Soc. London 33: 370, 1882. MAJOR, R. H.: Xanthoma Diabeticorum, Bull. Johns Hopkins Hasp. 35: 27,1924.
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