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Differential Diagnosis of Dementias - Alzheimer's Association

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Pathologic Pr<strong>of</strong>iles <strong>of</strong> <strong>Dementias</strong><br />

Pathologic Signs AD PDD DLB VaD bvFTD<br />

Neuritic plaques ●●● ● ●● - -<br />

NFTs ●●● ● ●● - -<br />

Cortical Lewy bodies ● ● ●● - -<br />

Subcortical Lewy bodies ● ●●● ●●● - -<br />

Ischemic damage ●● - - ●●● -<br />

Tau or TDP-43 inclusions - - - - ●●●<br />

Biochemical Deficit AD PDD DLB VD FTD<br />

Cholinergic ●●● ●●●● ●●● -/● -<br />

Dopaminergic ● ●●● ●●● - -<br />

- Generally absent ● Infrequent ●● Typical ●●● Hallmark Feature ●●●● Severe Deficit<br />

1. Stahl SM. Stahl's essential psychopharmacology: neuroscientific basis and practical applications. 3rd ed, Fully rev. and expanded. ed. Cambridge ; New York: Cambridge<br />

University Press; 2008. 2. Geldmacher D. Alzheimer’s Disease. Textbook <strong>of</strong> Alzheimer disease and other dementias. 1st ed. Weiner MF, Lipton AM, eds. Washington, DC:<br />

American Psychiatric Pub.; 2009. 3. Tarawneh R, Galvin JE. Dementia with Lewy Bodies and other Synucleinopathies. Textbook <strong>of</strong> Alzheimer disease and other dementias. 1st<br />

ed. Weiner MF, Lipton AM, eds. Washington, DC: American Psychiatric Pub.; 2009. 4. Bird TD, Miller BL. Alzheimer’s disease and other dementias. Harrison’s Principles <strong>of</strong><br />

Internal Medicine. 16th ed. Kasper DL, Braunwald E, Fauci, AS, et al., eds. New York, NY: McGraw-Hill; 2005. 5. Szoeke CE, Campbell S, Chiu E et al, Vascular Cognitive<br />

Disorder. Textbook <strong>of</strong> Alzheimer disease and other dementias. 1st ed. Weiner MF, Lipton AM, eds. Washington, DC: American Psychiatric Pub.; 2009. 6. Rascovsky K, Hodges<br />

JR, Knopman D, et al. Sensitivity <strong>of</strong> revised diagnostic criteria for the behavioural variant <strong>of</strong> frontotemporal dementia. Brain. Sep 2011;134(Pt 9):2456-2477. 7. Bohnen NI, Kaufer<br />

DI, Ivanco LS, et al. Cortical cholinergic function is more severely affected in Parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. 28<br />

Arch Neurol. 2003;60:1745-1748.

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