Differential Diagnosis of Dementias - Alzheimer's Association

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Core Clinical Behavioral Variant of Frontal Temporal Dementia • Progressive deterioration of behavior and/or cognition with ≥ 3 early: 1 – Behavioral disinhibition – Apathy – Loss of sympathy/empathy – Perseverative, stereotyped or compulsive behavior – Hyperorality – Executive deficits with relative sparing of memory and visuospatial function • Frontal and/or anterior temporal atrophy on MRI or CT 1 • Tactless and impulsive behavior 2,3 1. Rascovsky K, Hodges JR, Knopman D, et al. Brain. Sep 2011;134(Pt 9):2456-2477. 2. Neary D, Snowden JS, Gustafson L, et al. Neurology. Dec 1998;51(6):1546-1554. 3. McKhann GM, Albert MS, Grossman M, et al. Arch Neurol. Nov 2001;58(11):1803-1809. 24
Imaging in the Diagnosis • Left - AD shows prominent sulci in tempo-parietal areas, typically accompanied by ventricle enlargement • Middle- VaD most often shows cerebrovascular lesions on T2-weighted MRI • Right - FTD shows prominent sulci in frontotemporal areas with relative parietal and occipital sparing 25
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Page 7 and 8: Clinical Evaluation for Dementia 1
Page 9 and 10: Delirium is a Reversible Cause of C
Page 11 and 12: Examples of Cognitive Assessment To
Page 13 and 14: The Informant Interview: The AD8
Page 15 and 16: Montreal Cognitive Assessment (MoCA
Page 17 and 18: Rapid Brief Cognitive Screens: Pros
Page 19 and 20: Core Clinical Alzheimer’s Dementi
Page 21 and 22: Core Clinical Dementia with Lewy Bo
Page 23: Frontotemporal Dementia • FTD may
Page 27 and 28: Neuropsychiatric Symptoms in Dement
Page 29 and 30: Current FDA-Approved Therapies AD P
Page 31 and 32: Caregiver Challenges in Different T

Differential Diagnosis of Dementias - Alzheimer's Association

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