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Differential Diagnosis of Dementias - Alzheimer's Association

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Core<br />

Clinical<br />

Behavioral Variant <strong>of</strong> Frontal Temporal<br />

Dementia<br />

• Progressive deterioration <strong>of</strong> behavior<br />

and/or cognition with ≥ 3 early: 1<br />

– Behavioral disinhibition<br />

– Apathy<br />

– Loss <strong>of</strong> sympathy/empathy<br />

– Perseverative, stereotyped or<br />

compulsive behavior<br />

– Hyperorality<br />

– Executive deficits with relative<br />

sparing <strong>of</strong> memory and visuospatial<br />

function<br />

• Frontal and/or anterior temporal<br />

atrophy on MRI or CT 1<br />

• Tactless and impulsive behavior 2,3<br />

1. Rascovsky K, Hodges JR, Knopman D, et al. Brain. Sep 2011;134(Pt 9):2456-2477. 2. Neary D, Snowden JS, Gustafson L, et al. Neurology. Dec 1998;51(6):1546-1554. 3.<br />

McKhann GM, Albert MS, Grossman M, et al. Arch Neurol. Nov 2001;58(11):1803-1809.<br />

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