Differential Diagnosis of Dementias - Alzheimer's Association
Differential Diagnosis of Dementias - Alzheimer's Association Differential Diagnosis of Dementias - Alzheimer's Association
Core Clinical Parkinson’s Disease Dementia • Develops in the context of established PD (>2 years) 1 • Cognitive and motor slowing with significant impairments in: 1,2 – Executive function – Memory retrieval • A decline from premorbid levels, with deficits sufficient to impair function 1,2 • Slowing of cognitive processes/processing speed 2 • Fluctuating attention deficits 2 PDD affects the basal ganglia first, and disrupts ascending subcortical circuits 3 • Difficulties with abstraction and visuospatial skills 2 1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition. Text Revision. (DSM-IV-TR ® .) Washington, DC: American Psychiatric Association; 2000. Emre M, Aarsland D, Brown R, et al. Mov Disord. Sep 15 2007;22(12):1689-1707; quiz 1837. 3. Tarawneh R, Galvin JE. Dementia with Lewy Bodies and 20 other Synucleinopathies. In: Weiner MF, Lipton AM, eds. Textbook of Alzheimer disease and other dementias. 1st ed. Washington, DC: American Psychiatric Pub.; 2009.
Core Clinical Dementia with Lewy Bodies • Fluctuating cognition with pronounced variations in attention and alertness 1 • Recurrent detailed visual hallucinations, • Spontaneous features of parkinsonism 1 • Suggestive features 1 • REM sleep behavior disorder • Severe neuroleptic sensitivity • Impairment in attention, visual perception and visual construction 1 • Memory is relatively spared early on, but deficit evident with progression 1 • Cognitive and motor symptoms often copresent DLB has basal ganglia, transitional, cortical forms 2 1. McKeith IG, et al. Neurology. 2005;65:1863-1872. 2. Tarawneh R, Galvin JE. Dementia with Lewy Bodies and other Synucleinopathies. In: Weiner MF, Lipton AM, eds. Textbook of Alzheimer disease and other dementias. 1st ed. Washington, DC: American Psychiatric Pub.; 2009. 21
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- Page 5 and 6: The Typical Dementia Scenario • P
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- Page 13 and 14: The Informant Interview: The AD8
- Page 15 and 16: Montreal Cognitive Assessment (MoCA
- Page 17 and 18: Rapid Brief Cognitive Screens: Pros
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Core<br />
Clinical<br />
Parkinson’s Disease Dementia<br />
• Develops in the context <strong>of</strong> established PD (>2<br />
years) 1<br />
• Cognitive and motor slowing with significant<br />
impairments in: 1,2<br />
– Executive function<br />
– Memory retrieval<br />
• A decline from premorbid levels, with deficits<br />
sufficient to impair function 1,2<br />
• Slowing <strong>of</strong> cognitive processes/processing<br />
speed 2<br />
• Fluctuating attention deficits 2<br />
PDD affects the<br />
basal ganglia<br />
first, and<br />
disrupts<br />
ascending<br />
subcortical<br />
circuits 3<br />
• Difficulties with abstraction and visuospatial<br />
skills 2<br />
1. American Psychiatric <strong>Association</strong>. Diagnostic and Statistical Manual <strong>of</strong> Mental Disorders. Fourth Edition. Text Revision. (DSM-IV-TR ® .) Washington, DC: American Psychiatric<br />
<strong>Association</strong>; 2000. Emre M, Aarsland D, Brown R, et al. Mov Disord. Sep 15 2007;22(12):1689-1707; quiz 1837. 3. Tarawneh R, Galvin JE. Dementia with Lewy Bodies and 20<br />
other Synucleinopathies. In: Weiner MF, Lipton AM, eds. Textbook <strong>of</strong> Alzheimer disease and other dementias. 1st ed. Washington, DC: American Psychiatric Pub.; 2009.
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