Astrup A et al. Am J Clin - American Heart Association

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Reduced Total/HDL Cholesterol with Both Carbohydrate Reduction and Weight Loss ∆ Total/HDL cholesterol 0 -.1 -.2 -.3 -.4 -.5 -.6 -.7 -.8 -.9 Higher sat same fat 20 25 30 35 40 45 50 55 % Carbohydrate Before weight loss After weight loss Krauss RM, et al. 2006; 83: 1025-1031
Association of saturated fat with serum cholesterol is modified by body weight Saturated fat intake was not associated with serum cholesterol in obese versus lean men. • 120 + 100-119 < 100 x Hawaii • Japan Kato et al., Am J Epid 97(5), 1973 Even in young, healthy non-obese men, the plasma lipid response was associated with BMI. Jansen S et al. J Nutr 1998; 128:1144-9. Insulin resistance has also been associated with a reduced LDL response to reductions in saturated fat. Lefevre M et al. Am J Clin Nutr 2005; 82:957-63.
Page 1 and 2: Saturated Fat and Cardiovascular Di
Page 3 and 4: CHD Mortality is Correlated with Pl
Page 5 and 6: Atherogenic Dyslipidemia Obesity In
Page 7: Saturated fat increases large and m
Page 11 and 12: Saturated Fat and CVD Model Dietary
Page 13 and 14: Saturated Fat & Other CVD Risk Fact
Page 15 and 16: What is the evidence for an associa
Page 17 and 18: RCTs with high PUFA and reduced SFA
Page 19 and 20: Women’s Health Initiative: Replac
Page 21 and 22: Lessons from RCTs Replacement of s
Page 23 and 24: Siri-Tarino P W et al. Am J Clin Nu
Page 25 and 26: Study Selection Process Siri-Tarino
Page 27 and 28: Saturated fat was not associated wi
Page 29 and 30: Caveats and Considerations
Page 31 and 32: Modulation by Replacement Nutrient
Page 33 and 34: Summary There is insufficient evid
Page 35 and 36: Addressing the Controversy Assertio
Page 37 and 38: Addressing the Controversy Assertio
Page 39 and 40: Saturated Fat & CVD in Context PUBL

Astrup A et al. Am J Clin - American Heart Association

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