Astrup A et al. Am J Clin - American Heart Association

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Addressing the Controversy Assertion: Inclusion of serum cholesterol in models can obscure the saturated fat and CVD association. Response: Subgroup analysis in 9 CHD studies and 6 stroke studies that did not adjust for serum cholesterol (n=291,126) yielded results that did not differ significantly from those we reported for all 21 studies (n=347, 747). RR CHD = 1.13 (0.96, 1.33) RR stroke = 0.84 (0.63, 1.10) RR CVD = 1.02 (0.86, 1.19)
Addressing the Controversy Assertion: The saturated fat and CHD relation may differ for “hard” versus “soft” endpoints (RR ”hard” = 1.13 versus RR ”soft” = 0.99) Response: Our evaluation of this hypothesis yielded a non-significant pooled Our evaluation of this hypothesis yielded a non-significant pooled RR estimate of 1.18 (0.99-1.42) (n=7 studies that considered fatal CHD as the outcome variable). Siri-Tarino PW et al. Curr Athero Rep 2010; 12(6):384-90
Page 1 and 2: Saturated Fat and Cardiovascular Di
Page 3 and 4: CHD Mortality is Correlated with Pl
Page 5 and 6: Atherogenic Dyslipidemia Obesity In
Page 7 and 8: Saturated fat increases large and m
Page 9 and 10: Association of saturated fat with s
Page 11 and 12: Saturated Fat and CVD Model Dietary
Page 13 and 14: Saturated Fat & Other CVD Risk Fact
Page 15 and 16: What is the evidence for an associa
Page 17 and 18: RCTs with high PUFA and reduced SFA
Page 19 and 20: Women’s Health Initiative: Replac
Page 21 and 22: Lessons from RCTs Replacement of s
Page 23 and 24: Siri-Tarino P W et al. Am J Clin Nu
Page 25 and 26: Study Selection Process Siri-Tarino
Page 27 and 28: Saturated fat was not associated wi
Page 29 and 30: Caveats and Considerations
Page 31 and 32: Modulation by Replacement Nutrient
Page 33: Summary There is insufficient evid
Page 37 and 38: Addressing the Controversy Assertio
Page 39 and 40: Saturated Fat & CVD in Context PUBL

Astrup A et al. Am J Clin - American Heart Association

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