LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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SYNOPSIS [4] Hall, E. J. Radiobiology for the radiobiologist. J.B. Lippincott Company, Philadelphia.; 1994. [5] Criswell, T.; Leskov, K.; Miyamoto, S.; Luo, G.; Boothman, D. A. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 22:5813-5827; 2003. [6] Morgan, W. F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res 159:567-580; 2003. [7] Coutard, H. The Results and Methods of Treatment of Cancer by Radiation. Ann Surg 106:584-598; 1937. [8] Schmidt-Ullrich, R. K.; Dent, P.; Grant, S.; Mikkelsen, R. B.; Valerie, K. Signal transduction and cellular radiation responses. Radiat Res 153:245-257; 2000. [9] Prise, K. M.; Ahnstrom, G.; Belli, M.; Carlsson, J.; Frankenberg, D.; Kiefer, J.; Lobrich, M.; Michael, B. D.; Nygren, J.; Simone, G.; Stenerlow, B. A review of dsb induction data for varying quality radiations. Int J Radiat Biol 74:173-184; 1998. [10] Rasband, W. S.; Image, J. U. S. National Institutes of Health, Bethesda, USA. http://rsb.info.nih.gov/ij/. 1997-2006. [11] Maurya, D. K.; Salvi, V. P.; Nair, C. K. Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions. Mol Cell Biochem 280:209-217; 2005. [12] Konca, K.; Lankoff, A.; Banasik, A.; Lisowska, H.; Kuszewski, T.; Gozdz, S.; Koza, Z.; Wojcik, A. A cross-platform public domain PC image-analysis program for the comet assay. Mutat Res 534:15-20; 2003. [13] Green, L. C.; Wagner, D. A.; Glogowski, J.; Skipper, P. L.; Wishnok, J. S.; Tannenbaum, S. R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138; 1982. [14] Jeon, S. H.; Kang, M. G.; Kim, Y. H.; Jin, Y. H.; Lee, C.; Chung, H. Y.; Kwon, H.; Park, S. D.; Seong, R. H. A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. J Exp Med 185:1827-1836; 1997. [15] Russell, J.; Wheldon, T. E.; Stanton, P. A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis. Cancer Res 55:4915-4921; 1995. [16] Dahlberg, W. K.; Azzam, E. I.; Yu, Y.; Little, J. B. Response of human tumor cells of varying radiosensitivity and radiocurability to fractionated irradiation. Cancer Res 59:5365-5369; 1999. [17] Pearce, A. G.; Segura, T. M.; Rintala, A. C.; Rintala-Maki, N. D.; Lee, H. The generation and characterization of a radiation-resistant model system to study radioresistance in human breast cancer cells. Radiat Res 156:739-750; 2001. [18] Krengli, M.; Hug, E. B.; Adams, J. A.; Smith, A. R.; Tarbell, N. J.; Munzenrider, J. E. Proton radiation therapy for retinoblastoma: comparison of various intraocular tumor locations and beam arrangements. Int J Radiat Oncol Biol Phys 61:583-593; 2005. [19] St Clair, W. H.; Adams, J. A.; Bues, M.; Fullerton, B. C.; La Shell, S.; Kooy, H. M.; Loeffler, J. S.; Tarbell, N. J. Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma. Int J Radiat Oncol Biol Phys 58:727-734; 2004. [20] Chang, J. Y.; Zhang, X.; Wang, X.; Kang, Y.; Riley, B.; Bilton, S.; Mohan, R.; Komaki, R.; Cox, J. D. Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated 27
SYNOPSIS radiation therapy in Stage I or Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 65:1087-1096; 2006. [21] Fukumitsu, N.; Sugahara, S.; Nakayama, H.; Fukuda, K.; Mizumoto, M.; Abei, M.; Shoda, J.; Thono, E.; Tsuboi, K.; Tokuuye, K. A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 74:831-836; 2009. [22] Jones, B.; Dale, R. G.; Carabe-Fernandez, A. Charged particle therapy for cancer: the inheritance of the Cavendish scientists? Appl Radiat Isot 67:371-377; 2009. [23] Miralbell, R.; Crowell, C.; Suit, H. D. Potential improvement of three dimension treatment planning and proton therapy in the outcome of maxillary sinus cancer. Int J Radiat Oncol Biol Phys 22:305-310; 1992. [24] Ogata, T.; Teshima, T.; Kagawa, K.; Hishikawa, Y.; Takahashi, Y.; Kawaguchi, A.; Suzumoto, Y.; Nojima, K.; Furusawa, Y.; Matsuura, N. Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 65:113-120; 2005. [25] Schulz-Ertner, D.; Nikoghosyan, A.; Thilmann, C.; Haberer, T.; Jakel, O.; Karger, C.; Kraft, G.; Wannenmacher, M.; Debus, J. Results of carbon ion radiotherapy in 152 patients. Int J Radiat Oncol Biol Phys 58:631-640; 2004. [26] Tsuji, H.; Ishikawa, H.; Yanagi, T.; Hirasawa, N.; Kamada, T.; Mizoe, J. E.; Kanai, T.; Tsujii, H.; Ohnishi, Y. Carbon-ion radiotherapy for locally advanced or unfavorably located choroidal melanoma: a Phase I/II dose-escalation study. Int J Radiat Oncol Biol Phys 67:857-862; 2007. [27] Miyamoto, T.; Yamamoto, N.; Nishimura, H.; Koto, M.; Tsujii, H.; Mizoe, J. E.; Kamada, T.; Kato, H.; Yamada, S.; Morita, S.; Yoshikawa, K.; Kandatsu, S.; Fujisawa, T. Carbon ion radiotherapy for stage I non-small cell lung cancer. Radiother Oncol 66:127- 140; 2003. [28] Azzam, E. I.; de Toledo, S. M.; Gooding, T.; Little, J. B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res 150:497-504; 1998. [29] Azzam, E. I.; De Toledo, S. M.; Spitz, D. R.; Little, J. B. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alphaparticle-irradiated normal human fibroblast cultures. Cancer Res 62:5436-5442; 2002. List of Publications: 1. Ghosh, S.; Narang, H.; Sarma, A.; Krishna, M. DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; 2011 (In Press doi:10.1016/j.mrfmmm.2011.07.015). 2. Ghosh, S.; Narang, H.; Sarma, A.; Kaur, H.; Krishna, M. Activation of DNA damage response signaling in lung adenocarcinoma A549 cells following oxygen beam irradiation. Mutat Res 723:190-198; 2011. 3. Ghosh, S.; Bhat, N. N.; Santra, S.; Thomas, R. G.; Gupta, S. K.; Choudhury, R. K.; Krishna, M. Low energy proton beam induces efficient cell killing in A549 lung adenocarcinoma cells. Cancer Invest 28:615-622; 2010. 4. Ghosh, S.; Maurya, D. K.; Krishna, M. Role of iNOS in bystander signaling between macrophages and lymphoma cells. Int J Radiat Oncol Biol Phys 72:1567-1574; 2008. 28
Page 1: RADIATION INDUCED SIGNALING IN MAMM
Page 4 and 5: DECLARATION I, hereby declare that
Page 6 and 7: CONTENTS Page No. SYNOPSIS………
Page 8 and 9: 2.11 Measurement of NO production
Page 10 and 11: PREAMBLE SYNOPSIS Ionising radiatio
Page 12 and 13: SYNOPSIS Aims and Objectives: To St
Page 14 and 15: SYNOPSIS 2.6 Immunofluorescence sta
Page 16 and 17: SYNOPSIS ATM gene expression, which
Page 18 and 19: SYNOPSIS Percentage Survival 100 80
Page 20 and 21: SYNOPSIS Ratio of Rad52 to Actin Ra
Page 22 and 23: Relative Phosphorylation 45 40 35 3
Page 24 and 25: SYNOPSIS Fig. 3.3A Clonogenic Cell
Page 26 and 27: SYNOPSIS (A) Av No. of phospho BRCA
Page 28 and 29: SYNOPSIS Percentage Survival 120 10
Page 30 and 31: SYNOPSIS Fig.3.4B. Existance of cro
Page 32 and 33: SYNOPSIS Fig. 3.4EDNA damage in EL-
Page 34 and 35: SYNOPSIS subsequent cytotoxicity ca
Page 38 and 39: CHAPTER 1 INTRODUCTION INTRODUCTION
Page 40 and 41: CHAPTER 1 INTRODUCTION 15.8% 9.56%
Page 42 and 43: CHAPTER 1 INTRODUCTION far apart an
Page 44 and 45: CHAPTER 1 INTRODUCTION and are more
Page 46 and 47: CHAPTER 1 INTRODUCTION 1.3 DNA dama
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Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
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CHAPTER 1 INTRODUCTION becomes pote
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CHAPTER 2 MATERIALS AND METHODS MAT
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CHAPTER 2 MATERIALS AND METHODS 2.2
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CHAPTER 2 MATERIALS AND METHODS res
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CHAPTER 2 MATERIALS AND METHODS Arr
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CHAPTER 2 MATERIALS AND METHODS PBS
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CHAPTER 2 MATERIALS AND METHODS the
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CHAPTER 2 MATERIALS AND METHODS 2.1
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CHAPTER 3 RESULTS RESULTS 93
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CHAPTER 3 RESULTS fractionated regi
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CHAPTER 3 RESULTS On comparison of
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CHAPTER 3 RESULTS Table 3.1.2A List
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CHAPTER 3 RESULTS 80 NM_002185 IL7R
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CHAPTER 3 RESULTS SAA2 149 AU134977
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CHAPTER 3 RESULTS 221 LOC643167 RNA
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CHAPTER 3 RESULTS 299 BF244402 FBXO
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CHAPTER 3 RESULTS CDK4) 57 AU152107
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CHAPTER 3 RESULTS 134 AL045793 METT
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CHAPTER 3 RESULTS 58 AF237813 ABAT
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CHAPTER 3 RESULTS 127 AI809749 ORMD
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CHAPTER 3 RESULTS 31 BE615699 UNC84
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CHAPTER 3 RESULTS 47 AF026303 SULT1
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CHAPTER 3 RESULTS 117 BF062193 CYor
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CHAPTER 3 RESULTS 187 AL036662 ---
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CHAPTER 3 RESULTS 52 AV686514 EMP2
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CHAPTER 3 RESULTS exposed to 10 Gy
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CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
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CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
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CHAPTER 3 RESULTS Fig. 3.1.7 Transl
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CHAPTER 3 RESULTS 3.1.9 Stabilizati
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CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
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CHAPTER 3 RESULTS whereas only the
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CHAPTER 3 RESULTS with equal doses
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CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
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CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
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CHAPTER 3 RESULTS (7.5±0.64) (Fig.
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CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
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CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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