LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

More documents

Recommendations

Info

1574 I. J. Radiation Oncology d Biology d Physics Volume 72, Number 5, 2008 6. Hall EJ, Hei TK. Genomic instability and bystander effects induced by high-LET radiation. Oncogene 2003;22:7034–7042. 7. Prise KM, Folkard M, Michael BD. Bystander responses induced by low LET radiation. Oncogene 2003;22:7043–7049. 8. Matsumoto H, Hayashi S, Hatashita M, et al. Induction of radioresistance to accelerated carbon-ion beams in recipient cells by nitric oxide excreted from irradiated donor cells of human glioblastoma. Int J Radiat Biol 2000;76:1649–1657. 9. Matsumoto H, Hayashi S, Hatashita M, et al. Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat Res 2001;155:387–396. 10. Shao C, Furusawa Y, Aoki M, et al. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int J Radiat Biol 2002;78:837–844. 11. Iluki Y, Mizuno S, Goto R. g-irradiation-induced DNA damage enhance NO production via NF-kB activation in RAW 264.7 cells. Biochim Biophys Acta 2003;1593:159–167. 12. Camphausen K, Moses MA, Menard C, et al. Radiation abscopal antitumor effect is mediated through p53. Cancer Res 2003; 63:1990–1993. 13. Maurya DK, Adhikari S, Nair CK, et al. DNA protective properties of vanillin against gamma-radiation under different conditions: possible mechanisms. Mutat Res 2007;634:69–80. 14. Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal Biochem 1982;126:131–138. 15. Jeon SH, Kang MG, Kim YH, et al. A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. J Exp Med 1997;185:1827–1836. 16. Mitra AK, Krishna M. Radiation-induced bystander effect: activation of signaling molecules in K562 erythroleukemia cells. J Cell Biochem 2007;100:991–997. 17. Nagasawa H, Little JB. Induction of sister chromatid exchanges by extremely low doses of a-particles. Cancer Res 1992;52: 6394–6396. 18. Brach MA, Hass R, Sherman ML, et al. Ionizing radiation induces expression and binding activity of the nuclear factor kB. J Clin Invest 1991;88:691–695. 19. Ginn-Pease ME, Whisler RL. Redox signals and NF-kB activation in T cells. Free Radic Biol Med 1998;25:346–361. 20. Zhou H, Ivanov VN, Lien YC, et al. Mitochondrial function and nuclear factor-kappa-mediated signaling in radiation induced bystander effects. Cancer Res 2008;68:2233–2240. 21. Li N, Karin M. Ionizing radiation and short wavelength UV activate NF-kB through two distinct mechanisms. Proc Natl Acad Sci U S A 1998;95:13012–13017. 22. Lowenstein CJ, Alley EW, Raval P, et al. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon g and lipopolysaccharide. Proc Natl Acad Sci U S A 1993;90:9730–9734. 23. Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon g and bacterial lipopolysaccharide. J Exp Med 1993;177:1779–1784. 24. Martinez-Ruiz A, Lamas S. Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences. Cardiovasc Res 2007;75:220–228. 25. Mothersill C, Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int J Radiat Biol 1997;71: 421–427. 26. Kadhim MA, Moore SR, Goodwin EH. Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response. Mutat Res 2004;568:21–32. 27. Maragos CM, Morley D, Wink DA, et al. Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide: Vasorelaxant effects. J Med Chem 1991;34: 3242–3247. 28. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992;6:3051–3064. 29. Tamir S, Tannenbaum SR. The role of nitric oxide (NO) in the carcinogenic process. Biochim Biophys Acta 1996;1288: F31–F36. 30. Lancaster JR Jr. Diffusion of free nitric oxide. Methods Enzymol 1996;268:31–50. 31. Saran M, Bors W. Signaling by O2- and NO: How far can either radical, or any specific reaction product, transmit a message under in vivo conditions? Chem Biol Interact 1994;90:35–45. 32. Shao C, Stewart V, Folkard M, et al. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res 2003;63:8437–8442.
Page 1:
RADIATION INDUCED SIGNALING IN MAMM
Page 4 and 5:
DECLARATION I, hereby declare that
Page 6 and 7:
CONTENTS Page No. SYNOPSIS………
Page 8 and 9:
2.11 Measurement of NO production
Page 10 and 11:
PREAMBLE SYNOPSIS Ionising radiatio
Page 12 and 13:
SYNOPSIS Aims and Objectives: To St
Page 14 and 15:
SYNOPSIS 2.6 Immunofluorescence sta
Page 16 and 17:
SYNOPSIS ATM gene expression, which
Page 18 and 19:
SYNOPSIS Percentage Survival 100 80
Page 20 and 21:
SYNOPSIS Ratio of Rad52 to Actin Ra
Page 22 and 23:
Relative Phosphorylation 45 40 35 3
Page 24 and 25:
SYNOPSIS Fig. 3.3A Clonogenic Cell
Page 26 and 27:
SYNOPSIS (A) Av No. of phospho BRCA
Page 28 and 29:
SYNOPSIS Percentage Survival 120 10
Page 30 and 31:
SYNOPSIS Fig.3.4B. Existance of cro
Page 32 and 33:
SYNOPSIS Fig. 3.4EDNA damage in EL-
Page 34 and 35:
SYNOPSIS subsequent cytotoxicity ca
Page 36 and 37:
SYNOPSIS [4] Hall, E. J. Radiobiolo
Page 38 and 39:
CHAPTER 1 INTRODUCTION INTRODUCTION
Page 40 and 41:
CHAPTER 1 INTRODUCTION 15.8% 9.56%
Page 42 and 43:
CHAPTER 1 INTRODUCTION far apart an
Page 44 and 45:
CHAPTER 1 INTRODUCTION and are more
Page 46 and 47:
CHAPTER 1 INTRODUCTION 1.3 DNA dama
Page 48 and 49:
CHAPTER 1 INTRODUCTION associates w
Page 50 and 51:
CHAPTER 1 INTRODUCTION are unable t
Page 52 and 53:
CHAPTER 1 INTRODUCTION Perhaps one
Page 54 and 55:
CHAPTER 1 INTRODUCTION occurs at DS
Page 56 and 57:
CHAPTER 1 INTRODUCTION related prot
Page 58 and 59:
CHAPTER 1 INTRODUCTION damage must
Page 60 and 61:
CHAPTER 1 INTRODUCTION At the prese
Page 62 and 63:
CHAPTER 1 INTRODUCTION predominant
Page 64 and 65:
CHAPTER 1 INTRODUCTION provide a me
Page 66 and 67:
CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69:
CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71:
CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73:
CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75:
CHAPTER 1 INTRODUCTION interaction
Page 76 and 77:
CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79:
CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81:
CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83:
CHAPTER 1 INTRODUCTION well to the
Page 84 and 85:
CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87:
CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89:
CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91:
CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93:
CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95:
CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97:
CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99:
CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101:
CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103:
CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105:
CHAPTER 3 RESULTS fractionated regi
Page 106 and 107:
CHAPTER 3 RESULTS On comparison of
Page 108 and 109:
CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111:
CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113:
CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115:
CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117:
CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119:
CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121:
CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123:
CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125:
CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127:
CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129:
CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131:
CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133:
CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135:
CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137:
CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139:
CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141:
CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143:
CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145:
CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147:
CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149:
CHAPTER 3 RESULTS whereas only the
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
CHAPTER 3 RESULTS with equal doses
Page 156 and 157:
CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159:
CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161:
CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163:
Page 164 and 165:
CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167:
CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169:
CHAPTER 3 RESULTS in all the cells.
Page 170 and 171:
CHAPTER 3 RESULTS 3.3.2.3 Radiation
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
Page 178 and 179:
CHAPTER 3 RESULTS PMA stimulated U9
Page 180 and 181:
CHAPTER 3 RESULTS Fig.3.4.2. Exista
Page 182 and 183:
CHAPTER 3 RESULTS up-regulation of
Page 184 and 185:
CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
Page 186 and 187:
CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
Page 188 and 189:
CHAPTER 3 RESULTS 3.4.4 Bystander e
Page 190 and 191:
CHAPTER 3 RESULTS Fig.3.4.4b DNA da
Page 192 and 193:
CHAPTER 3 RESULTS Fig.3.4.5a Gene e
Page 194 and 195:
CHAPTER 4 DISCUSSION DISCUSSION 185
Page 196 and 197:
CHAPTER 4 DISCUSSION directly expos
Page 198 and 199:
CHAPTER 4 DISCUSSION dose is delive
Page 200 and 201:
CHAPTER 4 DISCUSSION A clear cause
Page 202 and 203:
CHAPTER 4 DISCUSSION 4.2 Proton bea
Page 204 and 205:
CHAPTER 4 DISCUSSION Although the e
Page 206 and 207:
CHAPTER 4 DISCUSSION Similar number
Page 208 and 209:
CHAPTER 4 DISCUSSION the mechanism
Page 210 and 211:
CHAPTER 4 DISCUSSION Thus unlike th
Page 212 and 213:
CHAPTER 4 DISCUSSION different from
Page 214 and 215:
CHAPTER 4 DISCUSSION upregulates ma
Page 216 and 217:
CHAPTER 4 DISCUSSION Numerous studi
Page 218 and 219:
CHAPTER 4 DISCUSSION inhibition of
Page 220 and 221:
CHAPTER 4 DISCUSSION The survival o
Page 222 and 223:
CHAPTER 5 REFERENCES [1] Khan, F. T
Page 224 and 225:
CHAPTER 5 REFERENCES [19] Woo, R. A
Page 226 and 227:
CHAPTER 5 REFERENCES [35] Nghiem, P
Page 228 and 229:
CHAPTER 5 REFERENCES [52] McKay, B.
Page 230 and 231:
CHAPTER 5 REFERENCES [69] Cary, R.
Page 232 and 233:
CHAPTER 5 REFERENCES [84] Uziel, T.
Page 234 and 235:
CHAPTER 5 REFERENCES [98] Liu, Y.;
Page 236 and 237:
CHAPTER 5 REFERENCES [111] Fei, P.;
Page 238 and 239:
CHAPTER 5 REFERENCES [127] Frank, K
Page 240 and 241:
CHAPTER 5 REFERENCES [141] Pierce,
Page 242 and 243:
CHAPTER 5 REFERENCES [156] Roots, R
Page 244 and 245:
CHAPTER 5 REFERENCES [171] Xia, Z.;
Page 246 and 247:
CHAPTER 5 REFERENCES (MAP) kinase c
Page 248 and 249:
CHAPTER 5 REFERENCES phosphorylatio
Page 250 and 251:
CHAPTER 5 REFERENCES [211] Anderson
Page 252 and 253:
CHAPTER 5 REFERENCES [229] Konca, K
Page 254 and 255:
CHAPTER 5 REFERENCES [245] Kastan,
Page 256 and 257:
CHAPTER 5 REFERENCES [261] Miralbel
Page 258 and 259:
CHAPTER 5 REFERENCES [278] Weizman,
Page 260 and 261: CHAPTER 5 REFERENCES [294] Zhou, H.
Page 262 and 263: PUBLICATIONS AND PRESENTATIONS Publ
Page 264 and 265: Mutation Research 729 (2012) 61-72
Page 266 and 267: S. Ghosh, M. Krishna / Mutation Res
Page 278 and 279: 12 S. Ghosh et al. / Mutation Resea
Page 288 and 289: 192 S. Ghosh et al. / Mutation Rese
Page 296 and 297: Cancer Invest Downloaded from infor
Page 304 and 305: 1568 I. J. Radiation Oncology d Bio
show all

LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?