LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

More documents

Recommendations

Info

CHAPTER 5 REFERENCES [211] Anderson, J. A.; Harper, J. V.; Cucinotta, F. A.; O'Neill, P. Participation of DNA- PKcs in DSB repair after exposure to high- and low-LET radiation. Radiat Res 174:195- 205; 2010. [212] Zafar, F.; Seidler, S. B.; Kronenberg, A.; Schild, D.; Wiese, C. Homologous recombination contributes to the repair of DNA double-strand breaks induced by highenergy iron ions. Radiat Res 173:27-39; 2010. [213] Harper, J. V.; Anderson, J. A.; O'Neill, P. Radiation induced DNA DSBs: Contribution from stalled replication forks? DNA Repair (Amst) 9:907-913; 2010. [214] Asaithamby, A.; Uematsu, N.; Chatterjee, A.; Story, M. D.; Burma, S.; Chen, D. J. Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res 169:437-446; 2008. [215] Hall, E. J. Radiobiology for the radiobiologist. J.B. Lippincott Company, Philadelphia.; 1994. [216] Mothersill, C.; Seymour, C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 71:421-427; 1997. [217] Mothersill, C.; Seymour, C. B. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat Res 149:256- 262; 1998. [218] Seymour, C.; Mothersill, C. Cell communication and the "bystander effect". Radiat Res 151:505-506; 1999. 241
CHAPTER 5 REFERENCES [219] Seymour, C. B.; Mothersill, C. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat Res 153:508-511; 2000. [220] Nagasawa, H.; Little, J. B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res 52:6394-6396; 1992. [221] Folkard, M.; Schettino, G.; Vojnovic, B.; Gilchrist, S.; Michette, A. G.; Pfauntsch, S. J.; Prise, K. M.; Michael, B. D. A focused ultrasoft x-ray microbeam for targeting cells individually with submicrometer accuracy. Radiat Res 156:796-804; 2001. [222] Randers-Pehrson, G.; Geard, C. R.; Johnson, G.; Elliston, C. D.; Brenner, D. J. The Columbia University single-ion microbeam. Radiat Res 156:210-214; 2001. [223] Ballarini, F.; Biaggi, M.; Ottolenghi, A.; Sapora, O. Cellular communication and bystander effects: a critical review for modelling low-dose radiation action. Mutat Res 501:1-12; 2002. [224] Ziegler, J. F. The Stopping and Range of Ions in Matter, http://www.srim.org/. [225] Ziegler, J. F.; Bierserk, J. P.; Littmark, U. Stopping and ranges of ions in matter. Pergamon Press, New York; 1985. [226] Kraft, G. Tumor therapy with heavy charged particles. Prog Part Nucl Phys 45:S473-S544; 2000. [227] Rasband, W. S.; Image, J. U. S. <strong>National</strong> Institutes of Health, Bethesda, USA. http://rsb.info.nih.gov/ij/. 1997-2006. [228] Maurya, D. K.; Salvi, V. P.; Nair, C. K. Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions. Mol Cell Biochem 280:209-217; 2005. 242
Page 1:
RADIATION INDUCED SIGNALING IN MAMM
Page 4 and 5:
DECLARATION I, hereby declare that
Page 6 and 7:
CONTENTS Page No. SYNOPSIS………
Page 8 and 9:
2.11 Measurement of NO production
Page 10 and 11:
PREAMBLE SYNOPSIS Ionising radiatio
Page 12 and 13:
SYNOPSIS Aims and Objectives: To St
Page 14 and 15:
SYNOPSIS 2.6 Immunofluorescence sta
Page 16 and 17:
SYNOPSIS ATM gene expression, which
Page 18 and 19:
SYNOPSIS Percentage Survival 100 80
Page 20 and 21:
SYNOPSIS Ratio of Rad52 to Actin Ra
Page 22 and 23:
Relative Phosphorylation 45 40 35 3
Page 24 and 25:
SYNOPSIS Fig. 3.3A Clonogenic Cell
Page 26 and 27:
SYNOPSIS (A) Av No. of phospho BRCA
Page 28 and 29:
SYNOPSIS Percentage Survival 120 10
Page 30 and 31:
SYNOPSIS Fig.3.4B. Existance of cro
Page 32 and 33:
SYNOPSIS Fig. 3.4EDNA damage in EL-
Page 34 and 35:
SYNOPSIS subsequent cytotoxicity ca
Page 36 and 37:
SYNOPSIS [4] Hall, E. J. Radiobiolo
Page 38 and 39:
CHAPTER 1 INTRODUCTION INTRODUCTION
Page 40 and 41:
CHAPTER 1 INTRODUCTION 15.8% 9.56%
Page 42 and 43:
CHAPTER 1 INTRODUCTION far apart an
Page 44 and 45:
CHAPTER 1 INTRODUCTION and are more
Page 46 and 47:
CHAPTER 1 INTRODUCTION 1.3 DNA dama
Page 48 and 49:
CHAPTER 1 INTRODUCTION associates w
Page 50 and 51:
CHAPTER 1 INTRODUCTION are unable t
Page 52 and 53:
CHAPTER 1 INTRODUCTION Perhaps one
Page 54 and 55:
CHAPTER 1 INTRODUCTION occurs at DS
Page 56 and 57:
CHAPTER 1 INTRODUCTION related prot
Page 58 and 59:
CHAPTER 1 INTRODUCTION damage must
Page 60 and 61:
CHAPTER 1 INTRODUCTION At the prese
Page 62 and 63:
CHAPTER 1 INTRODUCTION predominant
Page 64 and 65:
CHAPTER 1 INTRODUCTION provide a me
Page 66 and 67:
CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69:
CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71:
CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73:
CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75:
CHAPTER 1 INTRODUCTION interaction
Page 76 and 77:
CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79:
CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81:
CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83:
CHAPTER 1 INTRODUCTION well to the
Page 84 and 85:
CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87:
CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89:
CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91:
CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93:
CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95:
CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97:
CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99:
CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101:
CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103:
CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105:
CHAPTER 3 RESULTS fractionated regi
Page 106 and 107:
CHAPTER 3 RESULTS On comparison of
Page 108 and 109:
CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111:
CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113:
CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115:
CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117:
CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119:
CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121:
CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123:
CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125:
CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127:
CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129:
CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131:
CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133:
CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135:
CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137:
CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139:
CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141:
CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143:
CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145:
CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147:
CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149:
CHAPTER 3 RESULTS whereas only the
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
CHAPTER 3 RESULTS with equal doses
Page 156 and 157:
CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159:
CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161:
CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163:
Page 164 and 165:
CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167:
CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169:
CHAPTER 3 RESULTS in all the cells.
Page 170 and 171:
CHAPTER 3 RESULTS 3.3.2.3 Radiation
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
Page 178 and 179:
CHAPTER 3 RESULTS PMA stimulated U9
Page 180 and 181:
CHAPTER 3 RESULTS Fig.3.4.2. Exista
Page 182 and 183:
CHAPTER 3 RESULTS up-regulation of
Page 184 and 185:
CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
Page 186 and 187:
CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
Page 188 and 189:
CHAPTER 3 RESULTS 3.4.4 Bystander e
Page 190 and 191:
CHAPTER 3 RESULTS Fig.3.4.4b DNA da
Page 192 and 193:
CHAPTER 3 RESULTS Fig.3.4.5a Gene e
Page 194 and 195:
CHAPTER 4 DISCUSSION DISCUSSION 185
Page 196 and 197:
CHAPTER 4 DISCUSSION directly expos
Page 198 and 199:
CHAPTER 4 DISCUSSION dose is delive
Page 200 and 201: CHAPTER 4 DISCUSSION A clear cause
Page 202 and 203: CHAPTER 4 DISCUSSION 4.2 Proton bea
Page 204 and 205: CHAPTER 4 DISCUSSION Although the e
Page 206 and 207: CHAPTER 4 DISCUSSION Similar number
Page 208 and 209: CHAPTER 4 DISCUSSION the mechanism
Page 210 and 211: CHAPTER 4 DISCUSSION Thus unlike th
Page 212 and 213: CHAPTER 4 DISCUSSION different from
Page 214 and 215: CHAPTER 4 DISCUSSION upregulates ma
Page 216 and 217: CHAPTER 4 DISCUSSION Numerous studi
Page 218 and 219: CHAPTER 4 DISCUSSION inhibition of
Page 220 and 221: CHAPTER 4 DISCUSSION The survival o
Page 222 and 223: CHAPTER 5 REFERENCES [1] Khan, F. T
Page 224 and 225: CHAPTER 5 REFERENCES [19] Woo, R. A
Page 226 and 227: CHAPTER 5 REFERENCES [35] Nghiem, P
Page 228 and 229: CHAPTER 5 REFERENCES [52] McKay, B.
Page 230 and 231: CHAPTER 5 REFERENCES [69] Cary, R.
Page 232 and 233: CHAPTER 5 REFERENCES [84] Uziel, T.
Page 234 and 235: CHAPTER 5 REFERENCES [98] Liu, Y.;
Page 236 and 237: CHAPTER 5 REFERENCES [111] Fei, P.;
Page 238 and 239: CHAPTER 5 REFERENCES [127] Frank, K
Page 240 and 241: CHAPTER 5 REFERENCES [141] Pierce,
Page 242 and 243: CHAPTER 5 REFERENCES [156] Roots, R
Page 244 and 245: CHAPTER 5 REFERENCES [171] Xia, Z.;
Page 246 and 247: CHAPTER 5 REFERENCES (MAP) kinase c
Page 248 and 249: CHAPTER 5 REFERENCES phosphorylatio
Page 252 and 253: CHAPTER 5 REFERENCES [229] Konca, K
Page 254 and 255: CHAPTER 5 REFERENCES [245] Kastan,
Page 256 and 257: CHAPTER 5 REFERENCES [261] Miralbel
Page 258 and 259: CHAPTER 5 REFERENCES [278] Weizman,
Page 260 and 261: CHAPTER 5 REFERENCES [294] Zhou, H.
Page 262 and 263: PUBLICATIONS AND PRESENTATIONS Publ
Page 264 and 265: Mutation Research 729 (2012) 61-72
Page 266 and 267: S. Ghosh, M. Krishna / Mutation Res
Page 278 and 279: 12 S. Ghosh et al. / Mutation Resea
Page 288 and 289: 192 S. Ghosh et al. / Mutation Rese
Page 296 and 297: Cancer Invest Downloaded from infor
Page 298 and 299: Cancer Invest Downloaded from infor
Page 300 and 301:
Cancer Invest Downloaded from infor
Page 302 and 303:
Cancer Invest Downloaded from infor
Page 304 and 305:
1568 I. J. Radiation Oncology d Bio
Page 306 and 307:
Page 308 and 309:
Page 310:
show all

LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

Create successful ePaper yourself

Delete template?

Save as template?