LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

More documents

Recommendations

Info

CHAPTER 5 REFERENCES [19] Woo, R. A.; McLure, K. G.; Lees-Miller, S. P.; Rancourt, D. E.; Lee, P. W. DNAdependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394:700-704; 1998. [20] Shieh, S. Y.; Ikeda, M.; Taya, Y.; Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334; 1997. [21] Rathmell, W. K.; Kaufmann, W. K.; Hurt, J. C.; Byrd, L. L.; Chu, G. DNAdependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res 57:68-74; 1997. [22] Burma, S.; Kurimasa, A.; Xie, G.; Taya, Y.; Araki, R.; Abe, M.; Crissman, H. A.; Ouyang, H.; Li, G. C.; Chen, D. J. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage. J Biol Chem 274:17139-17143; 1999. [23] Jhappan, C.; Yusufzai, T. M.; Anderson, S.; Anver, M. R.; Merlino, G. The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol Cell Biol 20:4075-4083; 2000. [24] Wang, S.; Guo, M.; Ouyang, H.; Li, X.; Cordon-Cardo, C.; Kurimasa, A.; Chen, D. J.; Fuks, Z.; Ling, C. C.; Li, G. C. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc Natl Acad Sci U S A 97:1584-1588; 2000. [25] Kurimasa, A.; Kumano, S.; Boubnov, N. V.; Story, M. D.; Tung, C. S.; Peterson, S. R.; Chen, D. J. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol 19:3877-3884; 1999. 215
CHAPTER 5 REFERENCES [26] Zou, L.; Elledge, S. J. Sensing DNA damage through ATRIP recognition of RPAssDNA complexes. Science 300:1542-1548; 2003. [27] You, Z.; Kong, L.; Newport, J. The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. J Biol Chem 277:27088-27093; 2002. [28] Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-2196; 2001. [29] Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3:155-168; 2003. [30] Brown, E. J.; Baltimore, D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 17:615-628; 2003. [31] Brown, E. J.; Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14:397-402; 2000. [32] Hekmat-Nejad, M.; You, Z.; Yee, M. C.; Newport, J. W.; Cimprich, K. A. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr Biol 10:1565-1573; 2000. [33] Dart, D. A.; Adams, K. E.; Akerman, I.; Lakin, N. D. Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. J Biol Chem 279:16433- 16440; 2004. [34] Shechter, D.; Costanzo, V.; Gautier, J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol 6:648-655; 2004. 216
Page 1:
RADIATION INDUCED SIGNALING IN MAMM
Page 4 and 5:
DECLARATION I, hereby declare that
Page 6 and 7:
CONTENTS Page No. SYNOPSIS………
Page 8 and 9:
2.11 Measurement of NO production
Page 10 and 11:
PREAMBLE SYNOPSIS Ionising radiatio
Page 12 and 13:
SYNOPSIS Aims and Objectives: To St
Page 14 and 15:
SYNOPSIS 2.6 Immunofluorescence sta
Page 16 and 17:
SYNOPSIS ATM gene expression, which
Page 18 and 19:
SYNOPSIS Percentage Survival 100 80
Page 20 and 21:
SYNOPSIS Ratio of Rad52 to Actin Ra
Page 22 and 23:
Relative Phosphorylation 45 40 35 3
Page 24 and 25:
SYNOPSIS Fig. 3.3A Clonogenic Cell
Page 26 and 27:
SYNOPSIS (A) Av No. of phospho BRCA
Page 28 and 29:
SYNOPSIS Percentage Survival 120 10
Page 30 and 31:
SYNOPSIS Fig.3.4B. Existance of cro
Page 32 and 33:
SYNOPSIS Fig. 3.4EDNA damage in EL-
Page 34 and 35:
SYNOPSIS subsequent cytotoxicity ca
Page 36 and 37:
SYNOPSIS [4] Hall, E. J. Radiobiolo
Page 38 and 39:
CHAPTER 1 INTRODUCTION INTRODUCTION
Page 40 and 41:
CHAPTER 1 INTRODUCTION 15.8% 9.56%
Page 42 and 43:
CHAPTER 1 INTRODUCTION far apart an
Page 44 and 45:
CHAPTER 1 INTRODUCTION and are more
Page 46 and 47:
CHAPTER 1 INTRODUCTION 1.3 DNA dama
Page 48 and 49:
CHAPTER 1 INTRODUCTION associates w
Page 50 and 51:
CHAPTER 1 INTRODUCTION are unable t
Page 52 and 53:
CHAPTER 1 INTRODUCTION Perhaps one
Page 54 and 55:
CHAPTER 1 INTRODUCTION occurs at DS
Page 56 and 57:
CHAPTER 1 INTRODUCTION related prot
Page 58 and 59:
CHAPTER 1 INTRODUCTION damage must
Page 60 and 61:
CHAPTER 1 INTRODUCTION At the prese
Page 62 and 63:
CHAPTER 1 INTRODUCTION predominant
Page 64 and 65:
CHAPTER 1 INTRODUCTION provide a me
Page 66 and 67:
CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69:
CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71:
CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73:
CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75:
CHAPTER 1 INTRODUCTION interaction
Page 76 and 77:
CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79:
CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81:
CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83:
CHAPTER 1 INTRODUCTION well to the
Page 84 and 85:
CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87:
CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89:
CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91:
CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93:
CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95:
CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97:
CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99:
CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101:
CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103:
CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105:
CHAPTER 3 RESULTS fractionated regi
Page 106 and 107:
CHAPTER 3 RESULTS On comparison of
Page 108 and 109:
CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111:
CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113:
CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115:
CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117:
CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119:
CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121:
CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123:
CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125:
CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127:
CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129:
CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131:
CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133:
CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135:
CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137:
CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139:
CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141:
CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143:
CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145:
CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147:
CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149:
CHAPTER 3 RESULTS whereas only the
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
CHAPTER 3 RESULTS with equal doses
Page 156 and 157:
CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159:
CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161:
CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163:
Page 164 and 165:
CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167:
CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169:
CHAPTER 3 RESULTS in all the cells.
Page 170 and 171:
CHAPTER 3 RESULTS 3.3.2.3 Radiation
Page 172 and 173:
Page 174 and 175: CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
Page 176 and 177: CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
Page 178 and 179: CHAPTER 3 RESULTS PMA stimulated U9
Page 180 and 181: CHAPTER 3 RESULTS Fig.3.4.2. Exista
Page 182 and 183: CHAPTER 3 RESULTS up-regulation of
Page 184 and 185: CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
Page 186 and 187: CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
Page 188 and 189: CHAPTER 3 RESULTS 3.4.4 Bystander e
Page 190 and 191: CHAPTER 3 RESULTS Fig.3.4.4b DNA da
Page 192 and 193: CHAPTER 3 RESULTS Fig.3.4.5a Gene e
Page 194 and 195: CHAPTER 4 DISCUSSION DISCUSSION 185
Page 196 and 197: CHAPTER 4 DISCUSSION directly expos
Page 198 and 199: CHAPTER 4 DISCUSSION dose is delive
Page 200 and 201: CHAPTER 4 DISCUSSION A clear cause
Page 202 and 203: CHAPTER 4 DISCUSSION 4.2 Proton bea
Page 204 and 205: CHAPTER 4 DISCUSSION Although the e
Page 206 and 207: CHAPTER 4 DISCUSSION Similar number
Page 208 and 209: CHAPTER 4 DISCUSSION the mechanism
Page 210 and 211: CHAPTER 4 DISCUSSION Thus unlike th
Page 212 and 213: CHAPTER 4 DISCUSSION different from
Page 214 and 215: CHAPTER 4 DISCUSSION upregulates ma
Page 216 and 217: CHAPTER 4 DISCUSSION Numerous studi
Page 218 and 219: CHAPTER 4 DISCUSSION inhibition of
Page 220 and 221: CHAPTER 4 DISCUSSION The survival o
Page 222 and 223: CHAPTER 5 REFERENCES [1] Khan, F. T
Page 226 and 227: CHAPTER 5 REFERENCES [35] Nghiem, P
Page 228 and 229: CHAPTER 5 REFERENCES [52] McKay, B.
Page 230 and 231: CHAPTER 5 REFERENCES [69] Cary, R.
Page 232 and 233: CHAPTER 5 REFERENCES [84] Uziel, T.
Page 234 and 235: CHAPTER 5 REFERENCES [98] Liu, Y.;
Page 236 and 237: CHAPTER 5 REFERENCES [111] Fei, P.;
Page 238 and 239: CHAPTER 5 REFERENCES [127] Frank, K
Page 240 and 241: CHAPTER 5 REFERENCES [141] Pierce,
Page 242 and 243: CHAPTER 5 REFERENCES [156] Roots, R
Page 244 and 245: CHAPTER 5 REFERENCES [171] Xia, Z.;
Page 246 and 247: CHAPTER 5 REFERENCES (MAP) kinase c
Page 248 and 249: CHAPTER 5 REFERENCES phosphorylatio
Page 250 and 251: CHAPTER 5 REFERENCES [211] Anderson
Page 252 and 253: CHAPTER 5 REFERENCES [229] Konca, K
Page 254 and 255: CHAPTER 5 REFERENCES [245] Kastan,
Page 256 and 257: CHAPTER 5 REFERENCES [261] Miralbel
Page 258 and 259: CHAPTER 5 REFERENCES [278] Weizman,
Page 260 and 261: CHAPTER 5 REFERENCES [294] Zhou, H.
Page 262 and 263: PUBLICATIONS AND PRESENTATIONS Publ
Page 264 and 265: Mutation Research 729 (2012) 61-72
Page 266 and 267: S. Ghosh, M. Krishna / Mutation Res
Page 274 and 275:
S. Ghosh, M. Krishna / Mutation Res
Page 276 and 277:
Mutation Research 716 (2011) 10-19
Page 278 and 279:
12 S. Ghosh et al. / Mutation Resea
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Mutation Research 723 (2011) 190-19
Page 288 and 289:
192 S. Ghosh et al. / Mutation Rese
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
Page 296 and 297:
Cancer Invest Downloaded from infor
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
1568 I. J. Radiation Oncology d Bio
Page 306 and 307:
Page 308 and 309:
Page 310:
show all

LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

Create successful ePaper yourself

Delete template?

Save as template?