LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 187 AL036662 --- --- 188 AW591809 --- CDNA FLJ35091 fis, clone PLACE6005786 189 BE222109 --- Transcribed locus 190 AI693336 FOXA1 Forkhead box A1 191 AV659198 TncRNA trophoblast-derived noncoding RNA 192 AW015521 CAT Catalase 193 AI521618 TPM1 Tropomyosin 1 (alpha) 194 AA644178 IRS1 Insulin receptor substrate 1 195 AI342246 --- Transcribed locus 196 AW963634 --- Transcribed locus 197 AW954199 --- Transcribed locus 198 BF061543 --- Transcribed locus 199 AW962458 --- Transcribed locus 200 AA019641 --- Transcribed locus 201 BG260086 XDH xanthine dehydrogenase 202 BE877420 --- Transcribed locus 203 AW973232 RNF12 Ring finger protein 12 204 AI078033 --- Transcribed locus 205 AI791820 --- Transcribed locus 206 Transcribed locus, strongly similar to XP_001160512.1 PREDICTED: hypothetical protein [Pan troglodytes] AI291804 --- 207 AI458949 IFNGR1 interferon gamma receptor 1 208 AI498610 --- --- 209 AA167167 --- --- 210 AW292830 --- Transcribed locus 211 M15330 IL1B interleukin 1, beta Table 3.1.2F List of Down-regulated genes of 10Gy Vs 5X2Gy S.No Public ID Gene Symbol Gene Title 1 BC032247 RBL1 retinoblastoma-like 1 (p107) 2 BC008680 ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 3 BC026969 WDR67 WD repeat domain 67 4 BC040700 --- Homo sapiens, clone IMAGE:5580334, mRNA 5 AK096748 ZNF519 zinc finger protein 519 6 NM_006623 PHGDH phosphoglycerate dehydrogenase 7 BC000192 DHFR dihydrofolate reductase 8 NM_000791 DHFR dihydrofolate reductase 9 NM_015180 SYNE2 spectrin repeat containing, nuclear envelope 2 10 NM_002358 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 11 U77949 CDC6 cell division cycle 6 homolog (S. cerevisiae) 12 NM_001254 CDC6 cell division cycle 6 homolog (S. cerevisiae) 13 NM_001262 CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits 123
CHAPTER 3 RESULTS CDK4) 14 NM_003686 EXO1 exonuclease 1 15 AW772140 WDHD1 WD repeat and HMG-box DNA binding protein 1 16 NM_007086 WDHD1 WD repeat and HMG-box DNA binding protein 1 17 NM_002828 PTPN2 protein tyrosine phosphatase, non-receptor type 2 18 NM_001673 ASNS asparagine synthetase 19 AL365505 RBL1 retinoblastoma-like 1 (p107) 20 MGC39900 /// TMSL8 thymosin-like 8 /// thymosin beta15b NM_021992 21 NM_024908 WDR76 WD repeat domain 76 22 NM_002692 POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 23 NM_015653 RIBC2 RIB43A domain with coiled-coils 2 24 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E NM_030920 ANP32E 25 BC005832 KIAA0101 KIAA0101 26 BC005995 GINS4 GINS complex subunit 4 (Sld5 homolog) 27 AU132185 MKI67 antigen identified by monoclonal antibody Ki-67 28 BF001806 MKI67 antigen identified by monoclonal antibody Ki-67 29 AI695017 MTUS1 mitochondrial tumor suppressor 1 30 AL096842 MTUS1 mitochondrial tumor suppressor 1 31 T87225 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 32 PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) AW991219 PDS5A 33 BE615699 UNC84A unc-84 homolog A (C. elegans) 34 X95152 BRCA2 breast cancer 2, early onset 35 AL109696 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 36 37 AA905286 DLEU2 /// DLEU2L deleted in lymphocytic leukemia, 2 /// deleted in lymphocytic leukemia 2-like defective in sister chromatid cohesion 1 homolog (S. cerevisiae) NM_024094 DSCC1 38 NM_018365 MNS1 meiosis-specific nuclear structural 1 39 NM_024680 E2F8 E2F transcription factor 8 40 NM_022488 ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 41 NM_018518 MCM10 minichromosome maintenance complex component 10 42 AF360549 BRIP1 BRCA1 interacting protein C-terminal helicase 1 43 AA886335 CALML4 calmodulin-like 4 44 AI859865 MCM4 minichromosome maintenance complex component 4 45 AI859865 MCM4 minichromosome maintenance complex component 4 46 AI925583 ATAD2 ATPase family, AAA domain containing 2 47 BC005400 CENPK centromere protein K 48 AB042719 MCM10 minichromosome maintenance complex component 10 49 BC002493 TCF19 transcription factor 19 (SC1) 50 AY028916 MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 51 BC001104 NUPL1 nucleoporin like 1 124
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
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CHAPTER 1 INTRODUCTION hypersensiti
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CHAPTER 1 INTRODUCTION cycle-specif
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CHAPTER 1 INTRODUCTION 1.4 Overview
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CHAPTER 1 INTRODUCTION 1.4.1 Radiat
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CHAPTER 1 INTRODUCTION interaction
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CHAPTER 1 INTRODUCTION p90S6 kinase
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CHAPTER 1 INTRODUCTION CD4 (formerl
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CHAPTER 1 INTRODUCTION unrepaired d
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Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169: CHAPTER 3 RESULTS in all the cells.
Page 170 and 171: CHAPTER 3 RESULTS 3.3.2.3 Radiation
Page 176 and 177: CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
Page 178 and 179: CHAPTER 3 RESULTS PMA stimulated U9
Page 180 and 181: CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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