LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 47 AF026303 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 48 NM_005101 ISG15 ISG15 ubiquitin-like modifier 49 NM_005658 TRAF1 TNF receptor-associated factor 1 50 NM_001785 CDA cytidine deaminase 51 NM_000756 CRH corticotropin releasing hormone 52 NM_003733 OASL 2'-5'-oligoadenylate synthetase-like 53 NM_000777 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 54 NM_002185 IL7R interleukin 7 receptor 55 NM_016352 CPA4 carboxypeptidase A4 56 NM_005393 PLXNB3 plexin B3 57 NM_001086 AADAC arylacetamide deacetylase (esterase) 58 NM_002852 PTX3 pentraxin-related gene, rapidly induced by IL-1 beta 59 NM_002652 PIP prolactin-induced protein 60 NM_015364 LY96 lymphocyte antigen 96 61 FAM36A /// homeobox A7 /// family with sequence similarity 36, NM_006896 HOXA7 member A 62 egf-like module containing, mucin-like, hormone NM_001974 EMR1 receptor-like 1 63 NM_013314 BLNK B-cell linker 64 NM_002090 CXCL3 chemokine (C-X-C motif) ligand 3 65 SAA1 /// NM_030754 SAA2 serum amyloid A1 /// serum amyloid A2 66 AF204231 GOLGA8A golgi autoantigen, golgin subfamily a, 8A 67 BC001743 C7orf44 chromosome 7 open reading frame 44 68 AF237813 ABAT 4-aminobutyrate aminotransferase 69 AF237813 ABAT 4-aminobutyrate aminotransferase 70 X16354 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 71 M57731 CXCL2 chemokine (C-X-C motif) ligand 2 72 M87507 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 73 D26121 SF1 splicing factor 1 74 M11734 CSF2 colony stimulating factor 2 (granulocyte-macrophage) 75 AF164622 GOLGA8A /// GOLGA8B golgi autoantigen, golgin subfamily a, 8A /// golgi autoantigen, golgin subfamily a, 8B 76 M13436 INHBA inhibin, beta A 77 AF119863 MEG3 maternally expressed 3 78 AF063612 OASL 2'-5'-oligoadenylate synthetase-like 79 AF064771 DGKA diacylglycerol kinase, alpha 80kDa 80 U13699 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 81 U13700 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 119
CHAPTER 3 RESULTS 82 AF186255 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 83 AF043337 IL8 interleukin 8 84 U20489 PTPRO protein tyrosine phosphatase, receptor type, O 85 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) M76742 CEACAM1 86 D86983 PXDN peroxidasin homolog (Drosophila) 87 AW052179 COL4A5 collagen, type IV, alpha 5 (Alport syndrome) 88 BE327172 JUN Jun oncogene 89 AA083478 TRIM22 tripartite motif-containing 22 90 AW103422 PCBP2 poly(rC) binding protein 2 91 AA554945 --- Transcribed locus 92 AI912583 GLIPR1 GLI pathogenesis-related 1 (glioma) 93 X90579 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 94 X90579 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 95 LOC729222 PTPRF interacting protein, binding protein 1 (liprin beta AI962377 /// PPFIBP1 1) /// similar to mKIAA1230 protein 96 NM_006417 IFI44 interferon-induced protein 44 97 SAA1 /// M23699 SAA2 serum amyloid A1 /// serum amyloid A2 98 U79273 EIF4A1 Eukaryotic translation initiation factor 4A, isoform 1 99 AL080207 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 100 BE888744 IFIT2 interferon-induced protein with tetratricopeptide repeats 2 101 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) BF508244 AKR1C1 102 NM_000064 C3 complement component 3 103 NM_021730 NLRP1 NLR family, pyrin domain containing 1 104 NM_017734 PALMD palmdelphin 105 NM_004669 CLIC3 chloride intracellular channel 3 106 NM_016321 RHCG Rh family, C glycoprotein 107 NM_015900 PLA1A phospholipase A1 member A 108 NM_018194 HHAT hedgehog acyltransferase 109 AL136861 CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 110 oligonucleotide/oligosaccharide-binding fold containing AU157541 OBFC2A 2A 111 AK024680 --- CDNA: FLJ21027 fis, clone CAE07110 112 BE646573 NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 113 AB037925 NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 114 AB056106 ABI3BP ABI gene family, member 3 (NESH) binding protein 115 AL136680 GBP3 guanylate binding protein 3 116 AF113016 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 120
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
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CHAPTER 1 INTRODUCTION hypersensiti
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CHAPTER 1 INTRODUCTION cycle-specif
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CHAPTER 1 INTRODUCTION 1.4 Overview
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CHAPTER 1 INTRODUCTION 1.4.1 Radiat
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CHAPTER 1 INTRODUCTION interaction
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CHAPTER 1 INTRODUCTION p90S6 kinase
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Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169: CHAPTER 3 RESULTS in all the cells.
Page 170 and 171: CHAPTER 3 RESULTS 3.3.2.3 Radiation
Page 176 and 177: CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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