LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 31 BE615699 UNC84A unc-84 homolog A (C. elegans) 32 S76476 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 33 AL109696 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 34 defective in sister chromatid cohesion 1 homolog (S. cerevisiae) NM_024094 DSCC1 35 NM_018365 MNS1 meiosis-specific nuclear structural 1 36 NM_024749 VASH2 vasohibin 2 37 NM_024680 E2F8 E2F transcription factor 8 38 BC003186 GINS2 GINS complex subunit 2 (Psf2 homolog) 39 AA886335 CALML4 calmodulin-like 4 40 BF684446 AXIN2 axin 2 (conductin, axil) 41 AB042719 MCM10 minichromosome maintenance complex component 10 42 BC002493 TCF19 transcription factor 19 (SC1) 43 AF177340 CLDN2 claudin 2 44 AY028916 MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 45 AV686514 EMP2 epithelial membrane protein 2 46 AL512758 CPLX2 complexin 2 47 AI092930 WDR20 WD repeat domain 20 48 AW004016 ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 49 AA406603 CLCC1 Chloride channel CLIC-like 1 50 AI823645 PRIMA1 proline rich membrane anchor 1 51 AK024292 SGOL1 Shugoshin-like 1 (S. pombe) 52 BE670098 USP37 ubiquitin specific peptidase 37 53 AI953354 --- CDNA: FLJ20913 fis, clone ADSE00630 54 AA938184 --- Transcribed locus 55 AW269645 ECT2 Epithelial cell transforming sequence 2 oncogene 56 AL045793 METT10D methyltransferase 10 domain containing 57 R54683 MCM6 minichromosome maintenance complex component 6 58 AA019836 C18orf54 Chromosome 18 open reading frame 54 59 AI924134 --- Transcribed locus 60 BG283921 C18orf54 chromosome 18 open reading frame 54 61 AI144299 DHFR dihydrofolate reductase 62 AW025529 CALML4 calmodulin-like 4 Table 3.1.2E List of Up-regulated genes: 10Gy Vs 5X2Gy S.No Public ID Gene Symbol Gene Title 1 M21121 CCL5 chemokine (C-C motif) ligand 5 2 NM_153838 GPR115 G protein-coupled receptor 115 3 NM_005764 PDZK1IP1 PDZK1 interacting protein 1 4 AF043341 CCL5 chemokine (C-C motif) ligand 5 5 CA428769 RTN4 reticulon 4 6 AW079553 --- CDNA FLJ41020 fis, clone UTERU2019163 117
CHAPTER 3 RESULTS 7 AA580691 RBM25 RNA binding motif protein 25 8 AK055254 --- CDNA FLJ30692 fis, clone FCBBF2000677 9 BQ944989 STRAP Serine/threonine kinase receptor associated protein 10 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) BE708432 MALAT1 11 AL832227 BCL8 B-cell CLL/lymphoma 8 12 AL832227 BCL8 B-cell CLL/lymphoma 8 13 AF086134 --- Full length insert cDNA clone ZA88B06 14 BI868311 ARF1 ADP-ribosylation factor 1 15 AL832409 TGIF1 TGFB-induced factor homeobox 1 16 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 BC020765 SERPINE1 17 BC023629 PDLIM7 PDZ and LIM domain 7 (enigma) 18 BF111821 WSB1 WD repeat and SOCS box-containing 1 19 AF010314 ENC1 ectodermal-neural cortex (with BTB-like domain) 20 NM_003633 ENC1 ectodermal-neural cortex (with BTB-like domain) 21 BG491844 JUN jun oncogene 22 NM_002228 JUN jun oncogene 23 NM_002276 KRT19 keratin 19 24 NM_005562 LAMC2 laminin, gamma 2 25 BC002666 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 26 NM_001710 CFB complement factor B 27 NM_006290 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 28 NM_001548 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 29 AF097493 GLS glutaminase 30 NM_014905 GLS glutaminase 31 NM_001345 DGKA diacylglycerol kinase, alpha 80kDa 32 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase NM_004267 CHST2 2 33 NM_004585 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 34 NM_006851 GLIPR1 GLI pathogenesis-related 1 (glioma) 35 NM_001511 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 36 NM_004961 GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 37 NM_003155 STC1 stanniocalcin 1 38 NM_002985 CCL5 chemokine (C-C motif) ligand 5 39 NM_001549 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 40 NM_006994 BTN3A3 butyrophilin, subfamily 3, member A3 41 NM_006307 SRPX sushi-repeat-containing protein, X-linked 42 NM_000203 IDUA iduronidase, alpha-L- 43 NM_000576 IL1B interleukin 1, beta 44 AB046692 AOX1 aldehyde oxidase 1 45 NM_001159 AOX1 aldehyde oxidase 1 46 NM_000600 IL6 interleukin 6 (interferon, beta 2) 118
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
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CHAPTER 1 INTRODUCTION hypersensiti
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CHAPTER 1 INTRODUCTION cycle-specif
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CHAPTER 1 INTRODUCTION 1.4 Overview
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CHAPTER 1 INTRODUCTION 1.4.1 Radiat
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CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169: CHAPTER 3 RESULTS in all the cells.
Page 170 and 171: CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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