LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

More documents

Recommendations

Info

CHAPTER 3 RESULTS 127 AI809749 ORMDL1 ORM1-like 1 (S. cerevisiae) 128 AI810764 --- Transcribed locus 129 AA058832 TMEM178 transmembrane protein 178 130 AI559300 SPATA18 spermatogenesis associated 18 homolog (rat) 131 AI075407 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 132 AA760738 --- CDNA FLJ42331 fis, clone TSTOM2000588 133 BG252802 --- Transcribed locus 134 AA234096 MGC16121 hypothetical protein MGC16121 135 AI625235 C20orf199 chromosome 20 open reading frame 199 136 BE669858 SAMD9L sterile alpha motif domain containing 9-like 137 Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase AI207338 GART 138 BF510429 CLINT1 clathrin interactor 1 139 AL042483 SPATA18 spermatogenesis associated 18 homolog (rat) 140 AW003173 STC1 Stanniocalcin 1 141 AW014593 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 142 AW262311 --- --- 143 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) NM_014086 MALAT1 144 AK000106 --- CDNA FLJ20099 fis, clone COL04544 145 AU144005 --- CDNA FLJ11397 fis, clone HEMBA1000622 146 AB046817 SYTL2 synaptotagmin-like 2 147 AU155094 ANXA1 Annexin A1 148 oligonucleotide/oligosaccharide-binding fold containing 2A AV734843 OBFC2A 149 AK021804 --- CDNA FLJ38472 fis, clone FEBRA2022148 150 AV699657 TncRNA trophoblast-derived noncoding RNA 151 AW292765 --- CDNA FLJ42786 fis, clone BRAWH3006761 152 BF689253 SPOCD1 SPOC domain containing 1 153 AL036662 --- --- 154 H09245 WWC1 WW and C2 domain containing 1 155 AV659198 TncRNA trophoblast-derived noncoding RNA 156 AI521618 TPM1 Tropomyosin 1 (alpha) 157 AI342246 --- Transcribed locus 158 AW954199 --- Transcribed locus 159 BF061543 --- Transcribed locus 160 AW172407 --- CDNA FLJ37304 fis, clone BRAMY2016070 161 BF244402 FBXO32 F-box protein 32 162 AW962458 --- Transcribed locus 163 AA019641 --- Transcribed locus 164 BG260086 XDH xanthine dehydrogenase 165 BE877420 --- Transcribed locus 166 AI078033 --- Transcribed locus 115
CHAPTER 3 RESULTS 167 BG026159 --- CDNA FLJ42225 fis, clone THYMU2040427 168 AI986192 SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 169 AI458949 IFNGR1 interferon gamma receptor 1 170 AI498610 --- --- 171 BF224218 --- Transcribed locus 172 M15330 IL1B interleukin 1, beta Table 3.1.2D List of Down-regulated genes: 2Gy Vs 5X2Gy S.No Public ID Gene Symbol Gene Title 1 BC032247 RBL1 retinoblastoma-like 1 (p107) 2 BC008680 ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 3 BC026969 WDR67 WD repeat domain 67 4 BC043596 FANCB Fanconi anemia, complementation group B 5 AI917078 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 6 BG387892 RBL1 retinoblastoma-like 1 (p107) 7 AK021715 --- CDNA FLJ11653 fis, clone HEMBA1004538 8 BC040700 --- Homo sapiens, clone IMAGE:5580334, mRNA 9 AK096748 ZNF519 zinc finger protein 519 10 NM_006623 PHGDH phosphoglycerate dehydrogenase 11 NM_006739 MCM5 minichromosome maintenance complex component 5 12 NM_015180 SYNE2 spectrin repeat containing, nuclear envelope 2 13 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) NM_001262 CDKN2C 14 BE535746 REEP1 receptor accessory protein 1 15 NM_003609 HIRIP3 HIRA interacting protein 3 16 NM_003686 EXO1 exonuclease 1 17 NM_007086 WDHD1 WD repeat and HMG-box DNA binding protein 1 18 NM_001673 ASNS asparagine synthetase 19 MGC39900 NM_021992 /// TMSL8 thymosin-like 8 /// thymosin beta15b 20 NM_002692 POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 21 NM_015653 RIBC2 RIB43A domain with coiled-coils 2 22 SPC25, NDC80 kinetochore complex component, AF225416 SPC25 homolog (S. cerevisiae) 23 Z25425 NEK2 NIMA (never in mitosis gene a)-related kinase 2 24 BC005995 GINS4 GINS complex subunit 4 (Sld5 homolog) 25 AU152107 MKI67 antigen identified by monoclonal antibody Ki-67 26 AU132185 MKI67 antigen identified by monoclonal antibody Ki-67 27 BF001806 MKI67 antigen identified by monoclonal antibody Ki-67 28 AI695017 MTUS1 mitochondrial tumor suppressor 1 29 AL096842 MTUS1 mitochondrial tumor suppressor 1 30 T87225 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 116
Page 1:
RADIATION INDUCED SIGNALING IN MAMM
Page 4 and 5:
DECLARATION I, hereby declare that
Page 6 and 7:
CONTENTS Page No. SYNOPSIS………
Page 8 and 9:
2.11 Measurement of NO production
Page 10 and 11:
PREAMBLE SYNOPSIS Ionising radiatio
Page 12 and 13:
SYNOPSIS Aims and Objectives: To St
Page 14 and 15:
SYNOPSIS 2.6 Immunofluorescence sta
Page 16 and 17:
SYNOPSIS ATM gene expression, which
Page 18 and 19:
SYNOPSIS Percentage Survival 100 80
Page 20 and 21:
SYNOPSIS Ratio of Rad52 to Actin Ra
Page 22 and 23:
Relative Phosphorylation 45 40 35 3
Page 24 and 25:
SYNOPSIS Fig. 3.3A Clonogenic Cell
Page 26 and 27:
SYNOPSIS (A) Av No. of phospho BRCA
Page 28 and 29:
SYNOPSIS Percentage Survival 120 10
Page 30 and 31:
SYNOPSIS Fig.3.4B. Existance of cro
Page 32 and 33:
SYNOPSIS Fig. 3.4EDNA damage in EL-
Page 34 and 35:
SYNOPSIS subsequent cytotoxicity ca
Page 36 and 37:
SYNOPSIS [4] Hall, E. J. Radiobiolo
Page 38 and 39:
CHAPTER 1 INTRODUCTION INTRODUCTION
Page 40 and 41:
CHAPTER 1 INTRODUCTION 15.8% 9.56%
Page 42 and 43:
CHAPTER 1 INTRODUCTION far apart an
Page 44 and 45:
CHAPTER 1 INTRODUCTION and are more
Page 46 and 47:
CHAPTER 1 INTRODUCTION 1.3 DNA dama
Page 48 and 49:
CHAPTER 1 INTRODUCTION associates w
Page 50 and 51:
CHAPTER 1 INTRODUCTION are unable t
Page 52 and 53:
CHAPTER 1 INTRODUCTION Perhaps one
Page 54 and 55:
CHAPTER 1 INTRODUCTION occurs at DS
Page 56 and 57:
CHAPTER 1 INTRODUCTION related prot
Page 58 and 59:
CHAPTER 1 INTRODUCTION damage must
Page 60 and 61:
CHAPTER 1 INTRODUCTION At the prese
Page 62 and 63:
CHAPTER 1 INTRODUCTION predominant
Page 64 and 65:
CHAPTER 1 INTRODUCTION provide a me
Page 66 and 67:
CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69:
CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71:
CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73:
CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169: CHAPTER 3 RESULTS in all the cells.
Page 170 and 171: CHAPTER 3 RESULTS 3.3.2.3 Radiation
Page 174 and 175:
CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
Page 176 and 177:
CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
Page 178 and 179:
CHAPTER 3 RESULTS PMA stimulated U9
Page 180 and 181:
CHAPTER 3 RESULTS Fig.3.4.2. Exista
Page 182 and 183:
CHAPTER 3 RESULTS up-regulation of
Page 184 and 185:
CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
Page 186 and 187:
CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
Page 188 and 189:
CHAPTER 3 RESULTS 3.4.4 Bystander e
Page 190 and 191:
CHAPTER 3 RESULTS Fig.3.4.4b DNA da
Page 192 and 193:
CHAPTER 3 RESULTS Fig.3.4.5a Gene e
Page 194 and 195:
CHAPTER 4 DISCUSSION DISCUSSION 185
Page 196 and 197:
CHAPTER 4 DISCUSSION directly expos
Page 198 and 199:
CHAPTER 4 DISCUSSION dose is delive
Page 200 and 201:
CHAPTER 4 DISCUSSION A clear cause
Page 202 and 203:
CHAPTER 4 DISCUSSION 4.2 Proton bea
Page 204 and 205:
CHAPTER 4 DISCUSSION Although the e
Page 206 and 207:
CHAPTER 4 DISCUSSION Similar number
Page 208 and 209:
CHAPTER 4 DISCUSSION the mechanism
Page 210 and 211:
CHAPTER 4 DISCUSSION Thus unlike th
Page 212 and 213:
CHAPTER 4 DISCUSSION different from
Page 214 and 215:
CHAPTER 4 DISCUSSION upregulates ma
Page 216 and 217:
CHAPTER 4 DISCUSSION Numerous studi
Page 218 and 219:
CHAPTER 4 DISCUSSION inhibition of
Page 220 and 221:
CHAPTER 4 DISCUSSION The survival o
Page 222 and 223:
CHAPTER 5 REFERENCES [1] Khan, F. T
Page 224 and 225:
CHAPTER 5 REFERENCES [19] Woo, R. A
Page 226 and 227:
CHAPTER 5 REFERENCES [35] Nghiem, P
Page 228 and 229:
CHAPTER 5 REFERENCES [52] McKay, B.
Page 230 and 231:
CHAPTER 5 REFERENCES [69] Cary, R.
Page 232 and 233:
CHAPTER 5 REFERENCES [84] Uziel, T.
Page 234 and 235:
CHAPTER 5 REFERENCES [98] Liu, Y.;
Page 236 and 237:
CHAPTER 5 REFERENCES [111] Fei, P.;
Page 238 and 239:
CHAPTER 5 REFERENCES [127] Frank, K
Page 240 and 241:
CHAPTER 5 REFERENCES [141] Pierce,
Page 242 and 243:
CHAPTER 5 REFERENCES [156] Roots, R
Page 244 and 245:
CHAPTER 5 REFERENCES [171] Xia, Z.;
Page 246 and 247:
CHAPTER 5 REFERENCES (MAP) kinase c
Page 248 and 249:
CHAPTER 5 REFERENCES phosphorylatio
Page 250 and 251:
CHAPTER 5 REFERENCES [211] Anderson
Page 252 and 253:
CHAPTER 5 REFERENCES [229] Konca, K
Page 254 and 255:
CHAPTER 5 REFERENCES [245] Kastan,
Page 256 and 257:
CHAPTER 5 REFERENCES [261] Miralbel
Page 258 and 259:
CHAPTER 5 REFERENCES [278] Weizman,
Page 260 and 261:
CHAPTER 5 REFERENCES [294] Zhou, H.
Page 262 and 263:
PUBLICATIONS AND PRESENTATIONS Publ
Page 264 and 265:
Mutation Research 729 (2012) 61-72
Page 266 and 267:
S. Ghosh, M. Krishna / Mutation Res
Page 268 and 269:
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
12 S. Ghosh et al. / Mutation Resea
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Page 288 and 289:
192 S. Ghosh et al. / Mutation Rese
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
Page 296 and 297:
Cancer Invest Downloaded from infor
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
1568 I. J. Radiation Oncology d Bio
Page 306 and 307:
Page 308 and 309:
Page 310:
show all

LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

Create successful ePaper yourself

Delete template?

Save as template?