LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 58 AF237813 ABAT 4-aminobutyrate aminotransferase 59 AF237813 ABAT 4-aminobutyrate aminotransferase 60 X16354 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 61 M87507 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 62 M15329 IL1A interleukin 1, alpha 63 AF010446 MR1 major histocompatibility complex, class I-related 64 M11734 CSF2 colony stimulating factor 2 (granulocyte-macrophage) 65 M13436 INHBA inhibin, beta A 66 AF063612 OASL 2'-5'-oligoadenylate synthetase-like 67 AF064771 DGKA diacylglycerol kinase, alpha 80kDa 68 U13699 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 69 U13700 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 70 AF119873 SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 71 AF186255 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 72 AF043337 IL8 interleukin 8 73 M76742 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 74 D86983 PXDN peroxidasin homolog (Drosophila) 75 AL541302 SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 76 AW052179 COL4A5 collagen, type IV, alpha 5 (Alport syndrome) 77 AA083478 TRIM22 tripartite motif-containing 22 78 AA554945 --- Transcribed locus 79 AI337069 RSAD2 radical S-adenosyl methionine domain containing 2 80 AI912583 GLIPR1 GLI pathogenesis-related 1 (glioma) 81 X90579 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 82 X90579 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 83 NM_006417 IFI44 interferon-induced protein 44 84 SAA1 /// M23699 SAA2 serum amyloid A1 /// serum amyloid A2 85 AK000923 SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 86 W46388 SOD2 superoxide dismutase 2, mitochondrial 87 AL080207 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 88 BE888744 IFIT2 interferon-induced protein with tetratricopeptide repeats 2 89 NM_000064 C3 complement component 3 90 NM_004669 CLIC3 chloride intracellular channel 3 91 NM_015900 PLA1A phospholipase A1 member A 92 AL136861 CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 93 AF133207 HSPB8 heat shock 22kDa protein 8 113
CHAPTER 3 RESULTS 94 oligonucleotide/oligosaccharide-binding fold containing AU157541 OBFC2A 2A 95 AK024680 --- CDNA: FLJ21027 fis, clone CAE07110 96 AB056106 ABI3BP ABI gene family, member 3 (NESH) binding protein 97 AL136680 GBP3 guanylate binding protein 3 98 AF228422 C15orf48 chromosome 15 open reading frame 48 99 AA827878 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 100 AF113016 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 101 AF229179 TMEM27 transmembrane protein 27 102 AF132202 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 103 AI446756 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 104 AF001540 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 105 BG534952 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 106 AW005982 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 107 AI355441 --- CDNA FLJ26120 fis, clone SYN00419 108 N21643 --- CDNA FLJ39585 fis, clone SKMUS2006633 109 N21426 SYTL2 synaptotagmin-like 2 110 AW006123 FBXO32 F-box protein 32 111 N32834 GLIPR1 GLI pathogenesis-related 1 (glioma) 112 AV682252 GLIPR1 GLI pathogenesis-related 1 (glioma) 113 BE967311 MCC mutated in colorectal cancers 114 AL513673 CYGB cytoglobin 115 W80468 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 116 AA131041 IFIT2 interferon-induced protein with tetratricopeptide repeats 2 117 AU155361 TncRNA trophoblast-derived noncoding RNA 118 AA524669 LOC1001315 64 hypothetical protein LOC100131564 119 AI343467 --- CDNA FLJ11041 fis, clone PLACE1004405 120 BE673226 C15orf52 chromosome 15 open reading frame 52 121 AI459194 EGR1 Early growth response 1 122 AL037917 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 123 BF591483 NTN1 netrin 1 124 AI953847 RNF144B ring finger 144B 125 BE048571 MGC16121 hypothetical protein MGC16121 126 AA741307 SAMD9 sterile alpha motif domain containing 9 114
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
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CHAPTER 1 INTRODUCTION hypersensiti
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CHAPTER 1 INTRODUCTION cycle-specif
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CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163: CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169: CHAPTER 3 RESULTS in all the cells.
Page 170 and 171: CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.3 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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