LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 134 AL045793 METT10D methyltransferase 10 domain containing 135 R54683 MCM6 minichromosome maintenance complex component 6 136 AI220472 --- Transcribed locus 137 AI928037 RUNDC3B RUN domain containing 3B 138 AA019836 C18orf54 Chromosome 18 open reading frame 54 139 BF666241 RIF1 RAP1 interacting factor homolog (yeast) 140 AI733194 --- Transcribed locus 141 BF516341 --- Transcribed locus 142 AI360832 --- Homo sapiens, clone IMAGE:3660074, mRNA 143 AI684761 SYNE2 spectrin repeat containing, nuclear envelope 2 144 AI924134 --- Transcribed locus 145 AW300380 SYNE1 spectrin repeat containing, nuclear envelope 1 146 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A BF215018 SEMA3A 147 BG283921 C18orf54 chromosome 18 open reading frame 54 148 AI144299 DHFR dihydrofolate reductase 149 AW025529 CALML4 calmodulin-like 4 Table 3.1.2C List of Up-regulated genes: 2Gy Vs 5X2Gy S.No Public ID Gene Symbol Gene Title 1 M21121 CCL5 chemokine (C-C motif) ligand 5 2 NM_005764 PDZK1IP1 PDZK1 interacting protein 1 3 AF043341 CCL5 chemokine (C-C motif) ligand 5 4 BC039509 LOC643401 hypothetical protein LOC643401 5 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) BE708432 MALAT1 6 BC043411 --- Homo sapiens, clone IMAGE:6155889, mRNA 7 AL832227 BCL8 B-cell CLL/lymphoma 8 8 AL832227 BCL8 B-cell CLL/lymphoma 8 9 AF086134 --- Full length insert cDNA clone ZA88B06 10 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 BC020765 SERPINE1 11 BC023629 PDLIM7 PDZ and LIM domain 7 (enigma) 12 NM_001613 ACTA2 actin, alpha 2, smooth muscle, aorta 13 AF010314 ENC1 ectodermal-neural cortex (with BTB-like domain) 14 BG491844 JUN jun oncogene 15 NM_002228 JUN jun oncogene 16 NM_002276 KRT19 keratin 19 17 myxovirus (influenza virus) resistance 1, interferoninducible protein p78 (mouse) NM_002462 MX1 18 NM_005562 LAMC2 laminin, gamma 2 19 BC002666 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 111
CHAPTER 3 RESULTS 20 NM_001710 CFB complement factor B 21 AW117498 FOXO1 forkhead box O1 22 NM_004120 GBP2 guanylate binding protein 2, interferon-inducible 23 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) NM_000029 AGT 24 NM_001548 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 25 NM_001345 DGKA diacylglycerol kinase, alpha 80kDa 26 NM_005103 FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 27 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 NM_004267 CHST2 28 NM_004585 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 29 NM_006851 GLIPR1 GLI pathogenesis-related 1 (glioma) 30 NM_000698 ALOX5 arachidonate 5-lipoxygenase 31 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) NM_001511 CXCL1 32 NM_004961 GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 33 NM_002985 CCL5 chemokine (C-C motif) ligand 5 34 NM_001549 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 35 NM_000203 IDUA iduronidase, alpha-L- 36 NM_000576 IL1B interleukin 1, beta 37 AB046692 AOX1 aldehyde oxidase 1 38 NM_001159 AOX1 aldehyde oxidase 1 39 NM_000600 IL6 interleukin 6 (interferon, beta 2) 40 AF026303 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 41 NM_005101 ISG15 ISG15 ubiquitin-like modifier 42 NM_005658 TRAF1 TNF receptor-associated factor 1 43 NM_001785 CDA cytidine deaminase 44 NM_003733 OASL 2'-5'-oligoadenylate synthetase-like 45 NM_000777 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 46 NM_002185 IL7R interleukin 7 receptor 47 NM_016352 CPA4 carboxypeptidase A4 48 GABBR1 /// NM_006398 UBD 49 NM_001086 AADAC arylacetamide deacetylase (esterase) 50 NM_002652 PIP prolactin-induced protein 51 NM_015364 LY96 lymphocyte antigen 96 gamma-aminobutyric acid (GABA) B receptor, 1 /// ubiquitin D 52 egf-like module containing, mucin-like, hormone NM_001974 EMR1 receptor-like 1 53 NM_001531 MR1 major histocompatibility complex, class I-related 54 NM_013314 BLNK B-cell linker 55 SAA1 /// NM_030754 SAA2 serum amyloid A1 /// serum amyloid A2 56 AF204231 GOLGA8A golgi autoantigen, golgin subfamily a, 8A 57 BC001743 C7orf44 chromosome 7 open reading frame 44 112
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
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CHAPTER 1 INTRODUCTION hypersensiti
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CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163: CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
Page 168 and 169: CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.3 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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