LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS CDK4) 57 AU152107 MKI67 antigen identified by monoclonal antibody Ki-67 58 AU132185 MKI67 antigen identified by monoclonal antibody Ki-67 59 BF001806 MKI67 antigen identified by monoclonal antibody Ki-67 60 AU147044 MKI67 antigen identified by monoclonal antibody Ki-67 61 AI695017 MTUS1 mitochondrial tumor suppressor 1 62 BE552421 MTUS1 mitochondrial tumor suppressor 1 63 AL096842 MTUS1 mitochondrial tumor suppressor 1 64 D38553 NCAPH non-SMC condensin I complex, subunit H 65 BE045993 OIP5 Opa interacting protein 5 66 T87225 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 67 X95152 BRCA2 breast cancer 2, early onset 68 AL109696 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 69 BF973178 GTSE1 G-2 and S-phase expressed 1 70 solute carrier family 2 (facilitated glucose transporter), member 3 /// solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A14 /// AL110298 SLC2A3 71 AA807529 MCM5 minichromosome maintenance complex component 5 72 AJ251844 MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 73 NM_022346 NCAPG non-SMC condensin I complex, subunit G 74 NM_014109 ATAD2 ATPase family, AAA domain containing 2 75 AF118887 VAV3 vav 3 guanine nucleotide exchange factor 76 NM_012177 FBXO5 F-box protein 5 77 NM_020242 KIF15 kinesin family member 15 78 excision repair cross-complementing rodent repair NM_017669 ERCC6L deficiency, complementation group 6-like 79 NM_018365 MNS1 meiosis-specific nuclear structural 1 80 NM_018123 ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 81 NM_024680 E2F8 E2F transcription factor 8 82 NM_022488 ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 83 NM_018518 MCM10 minichromosome maintenance complex component 10 84 BC001651 CDCA8 cell division cycle associated 8 85 BC003186 GINS2 GINS complex subunit 2 (Psf2 homolog) 86 AF360549 BRIP1 BRCA1 interacting protein C-terminal helicase 1 87 AA886335 CALML4 calmodulin-like 4 88 AW195581 GPSM2 G-protein signaling modulator 2 (AGS3-like, C. elegans) 89 AI859865 MCM4 minichromosome maintenance complex component 4 90 solute carrier family 2 (facilitated glucose transporter), member 3 /// solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A14 /// AA778684 SLC2A3 91 BF684446 AXIN2 axin 2 (conductin, axil) 92 AI925583 ATAD2 ATPase family, AAA domain containing 2 93 AB042719 MCM10 minichromosome maintenance complex component 10 109
CHAPTER 3 RESULTS 94 BC002493 TCF19 transcription factor 19 (SC1) 95 AF177340 CLDN2 claudin 2 96 AL136840 MCM10 minichromosome maintenance complex component 10 97 AY028916 MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 98 AV686514 EMP2 epithelial membrane protein 2 99 AL512758 CPLX2 complexin 2 100 BE504653 RIF1 RAP1 interacting factor homolog (yeast) 101 AW003459 SLFN11 schlafen family member 11 102 103 AK024288 regulatory factor X, 2 (influences HLA class II expression) RFX2 LOC1001281 91 hypothetical protein LOC100128191 H28597 104 BF248364 CASC5 cancer susceptibility candidate 5 105 AW004016 ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 106 AI140305 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 107 BF059556 C18orf54 chromosome 18 open reading frame 54 108 N62196 ZNF367 zinc finger protein 367 109 AW572379 --- CDNA clone IMAGE:5263455 110 hCG_203303 9 hypothetical protein BC006136 AA805700 111 AI638593 C15orf42 chromosome 15 open reading frame 42 112 AA041523 C6orf176 chromosome 6 open reading frame 176 113 BE858063 LOC730631 Hypothetical LOC730631 114 AK024292 SGOL1 Shugoshin-like 1 (S. pombe) 115 BE670098 USP37 ubiquitin specific peptidase 37 116 asp (abnormal spindle) homolog, microcephaly associated (Drosophila) AK001380 ASPM 117 AI953354 --- CDNA: FLJ20913 fis, clone ADSE00630 118 AK026197 FBXO5 F-box protein 5 119 AL138828 FAM54A family with sequence similarity 54, member A 120 BG170335 ECT2 epithelial cell transforming sequence 2 oncogene 121 AI868315 PHF17 PHD finger protein 17 122 BF974463 CXorf56 chromosome X open reading frame 56 123 AA740849 ESCO2 establishment of cohesion 1 homolog 2 (S. cerevisiae) 124 AA938184 --- Transcribed locus 125 AW183154 KIF14 kinesin family member 14 126 AW269645 ECT2 Epithelial cell transforming sequence 2 oncogene 127 T90771 SYNC1 Syncoilin, intermediate filament 1 128 BF447038 SP8 Sp8 transcription factor 129 BE218107 EPHA5 EPH receptor A5 130 BE620598 LOC201725 hypothetical protein LOC201725 131 AA224205 CHEK1 CHK1 checkpoint homolog (S. pombe) 132 AA573088 LOC730631 Hypothetical LOC730631 133 AI860012 GAS2L3 Growth arrest-specific 2 like 3 110
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
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CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69: CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163: CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
Page 166 and 167: CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.3 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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