LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 299 BF244402 FBXO32 F-box protein 32 300 AW962458 --- Transcribed locus 301 AA019641 --- Transcribed locus 302 BG260086 XDH xanthine dehydrogenase 303 AW973232 RNF12 Ring finger protein 12 304 AW970888 --- CDNA clone IMAGE:5314281 305 AI078033 --- Transcribed locus 306 Transcribed locus, strongly similar to XP_001160512.1 PREDICTED: hypothetical protein [Pan troglodytes] AI291804 --- 307 AI458949 IFNGR1 interferon gamma receptor 1 308 W84667 --- --- 309 AI498610 --- --- 310 AA883831 --- Transcribed locus 311 BF224218 --- Transcribed locus 312 M15330 IL1B interleukin 1, beta Table 3.1.2B List of Down-regulated Genes: Control Vs 5X2 Gy S.No Public ID Gene Symbol Gene Title 1 NM_020380 CASC5 cancer susceptibility candidate 5 2 NM_144508 CASC5 cancer susceptibility candidate 5 3 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa NM_139052 TAF5 4 NM_001453 FOXC1 forkhead box C1 5 BC032247 RBL1 retinoblastoma-like 1 (p107) 6 BC008680 ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 7 sterile alpha motif and leucine zipper containing kinase AZK AF465843 ZAK 8 BC026969 WDR67 WD repeat domain 67 9 BC043596 FANCB Fanconi anemia, complementation group B 10 AI917078 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 11 BC041481 FLJ35848 hypothetical protein FLJ35848 12 BC040700 --- Homo sapiens, clone IMAGE:5580334, mRNA 13 AK096748 ZNF519 zinc finger protein 519 14 BC033560 --- CDNA clone IMAGE:4824158 15 NM_006623 PHGDH phosphoglycerate dehydrogenase 16 NM_006739 MCM5 minichromosome maintenance complex component 5 17 18 BE550486 SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 solute carrier family 2 (facilitated glucose transporter), member 3 NM_006931 SLC2A3 19 BC000192 DHFR dihydrofolate reductase 20 NM_015180 SYNE2 spectrin repeat containing, nuclear envelope 2 107
CHAPTER 3 RESULTS 21 NM_001254 CDC6 cell division cycle 6 homolog (S. cerevisiae) 22 NM_001262 CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 23 BF305380 GTSE1 G-2 and S-phase expressed 1 24 NM_004523 KIF11 kinesin family member 11 25 ARHGAP11 NM_014783 A Rho GTPase activating protein 11A 26 NM_003686 EXO1 exonuclease 1 27 NM_004856 KIF23 kinesin family member 23 28 NM_007086 WDHD1 WD repeat and HMG-box DNA binding protein 1 29 U17105 CCNF cyclin F 30 NM_014264 PLK4 polo-like kinase 4 (Drosophila) 31 AF154830 CPS1 carbamoyl-phosphate synthetase 1, mitochondrial 32 NM_002828 PTPN2 protein tyrosine phosphatase, non-receptor type 2 33 NM_001809 CENPA centromere protein A 34 NM_001673 ASNS asparagine synthetase 35 NM_004153 ORC1L origin recognition complex, subunit 1-like (yeast) 36 NM_013296 GPSM2 G-protein signaling modulator 2 (AGS3-like, C. elegans) 37 AL365505 RBL1 retinoblastoma-like 1 (p107) 38 NM_021992 MGC39900 /// TMSL8 thymosin-like 8 /// thymosin beta15b 39 NM_001274 CHEK1 CHK1 checkpoint homolog (S. pombe) 40 NM_002692 POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 41 NM_014645 CEP135 centrosomal protein 135kDa 42 NM_014875 KIF14 kinesin family member 14 43 NM_002530 NTRK3 neurotrophic tyrosine kinase, receptor, type 3 44 NM_015653 RIBC2 RIB43A domain with coiled-coils 2 45 NM_005196 CENPF centromere protein F, 350/400ka (mitosin) 46 U30872 CENPF centromere protein F, 350/400ka (mitosin) 47 AI373676 SMC3 structural maintenance of chromosomes 3 48 AW157094 ID4 inhibitor of DNA binding 4, dominant negative helixloop-helix protein 49 BG054916 PTCH1 patched homolog 1 (Drosophila) 50 AF225416 SPC25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 51 AF016535 ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 52 AF016535 ABCB1 /// ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 1 /// ATP-binding cassette, sub-family B (MDR/TAP), member 4 53 Z25425 NEK2 NIMA (never in mitosis gene a)-related kinase 2 54 BC005832 KIAA0101 KIAA0101 55 BC005995 GINS4 GINS complex subunit 4 (Sld5 homolog) 56 U17074 CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits 108
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
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CHAPTER 1 INTRODUCTION provide a me
Page 66 and 67: CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69: CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163: CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
Page 164 and 165: CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
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CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.3 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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