LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 221 LOC643167 RNA binding motif protein 39 /// similar to RNA-binding BE466173 /// RBM39 region (RNP1, RRM) containing 2 222 BE673226 C15orf52 chromosome 15 open reading frame 52 223 AK024898 --- CDNA: FLJ21245 fis, clone COL01184 224 AI459194 EGR1 Early growth response 1 225 AA632295 STON2 stonin 2 226 AL037917 MALAT1 227 AI817145 PDCD5 Programmed cell death 5 228 BF591483 NTN1 netrin 1 229 AB046848 NOPE neighbor of Punc E11 230 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) Transcribed locus, strongly similar to NP_005768.1 RNA binding motif protein 6 [Homo sapiens] AI041522 --- 231 AI953847 RNF144B ring finger 144B 232 BE645119 MGC13057 hypothetical protein MGC13057 233 BE048571 MGC16121 hypothetical protein MGC16121 234 AI927692 --- CDNA FLJ41270 fis, clone BRAMY2036387 235 AA741307 SAMD9 sterile alpha motif domain containing 9 236 Metastasis associated lung adenocarcinoma transcript 1 AI475544 MALAT1 (non-protein coding) 237 AI809749 ORMDL1 ORM1-like 1 (S. cerevisiae) 238 AW071793 MXD1 MAX dimerization protein 1 239 AW007289 ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 240 AI659800 C13orf31 chromosome 13 open reading frame 31 241 AI810764 --- Transcribed locus 242 AA058832 TMEM178 transmembrane protein 178 243 AI559300 SPATA18 spermatogenesis associated 18 homolog (rat) 244 AA741058 ATG16L2 ATG16 autophagy related 16-like 2 (S. cerevisiae) 245 AI075407 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 246 AA760738 --- CDNA FLJ42331 fis, clone TSTOM2000588 247 BG252802 --- Transcribed locus 248 AA902480 MGC5370 hypothetical protein MGC5370 249 AA234096 MGC16121 hypothetical protein MGC16121 250 AI625235 C20orf199 chromosome 20 open reading frame 199 251 Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase AI207338 GART 252 AI139993 --- Transcribed locus 253 PRP38 pre-mRNA processing factor 38 (yeast) domain N32872 PRPF38B containing B 254 BE326919 --- Transcribed locus 255 BF510429 CLINT1 clathrin interactor 1 256 AL042483 SPATA18 spermatogenesis associated 18 homolog (rat) 105
CHAPTER 3 RESULTS 257 AI912194 --- Transcribed locus 258 AK024931 GALNT10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- acetylgalactosaminyltransferase 10 (GalNAc-T10) 259 AI698574 TTLL6 tubulin tyrosine ligase-like family, member 6 260 AW262311 --- --- 261 metastasis associated lung adenocarcinoma transcript 1 NM_014086 MALAT1 (non-protein coding) 262 N90870 --- CDNA FLJ38472 fis, clone FEBRA2022148 263 AL137763 GRHL3 grainyhead-like 3 (Drosophila) 264 BE927772 SFRS3 Splicing factor, arginine/serine-rich 3 265 AV703311 SCARB1 scavenger receptor class B, member 1 266 AK000106 --- CDNA FLJ20099 fis, clone COL04544 267 AU156721 PAPPA pregnancy-associated plasma protein A, pappalysin 1 268 AB046817 SYTL2 synaptotagmin-like 2 269 AU155094 ANXA1 Annexin A1 270 AK021804 --- CDNA FLJ38472 fis, clone FEBRA2022148 271 AL034418 SULF2 sulfatase 2 272 AV699657 TncRNA trophoblast-derived noncoding RNA 273 AA828371 VPS13C Vacuolar protein sorting 13 homolog C (S. cerevisiae) 274 AW292765 --- CDNA FLJ42786 fis, clone BRAWH3006761 275 AI270356 --- CDNA FLJ31593 fis, clone NT2RI2002481 276 AI040887 ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 277 BF689253 SPOCD1 SPOC domain containing 1 278 AA889628 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 279 AL036662 --- --- 280 AA703280 --- --- 281 AW591809 --- CDNA FLJ35091 fis, clone PLACE6005786 282 AI693336 FOXA1 Forkhead box A1 283 AI359676 LOC727770 similar to ankyrin repeat domain 20 family, member A1 284 AI479082 FLJ41484 hypothetical LOC650669 285 AV659198 TncRNA trophoblast-derived noncoding RNA 286 AI307802 ANKRD29 ankyrin repeat domain 29 287 AI521618 TPM1 Tropomyosin 1 (alpha) 288 AI422414 --- Transcribed locus 289 AA876179 --- Transcribed locus 290 AI924046 --- Transcribed locus 291 BF512162 C3orf55 chromosome 3 open reading frame 55 292 AI342246 --- Transcribed locus 293 BF970185 --- Transcribed locus 294 AI743261 FAM98A Family with sequence similarity 98, member A 295 AI686890 --- Transcribed locus 296 BE274992 RNF144B ring finger 144B 297 BF061543 --- Transcribed locus 298 AW172407 --- CDNA FLJ37304 fis, clone BRAMY2016070 106
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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CHAPTER 1 INTRODUCTION predominant
Page 64 and 65: CHAPTER 1 INTRODUCTION provide a me
Page 66 and 67: CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69: CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
Page 162 and 163: CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
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CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
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CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.3 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.5 Phosp
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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