LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS SAA2 149 AU134977 TncRNA Trophoblast-derived noncoding RNA 150 AF070569 C17orf91 chromosome 17 open reading frame 91 151 AL080207 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 152 X83493 FAS Fas (TNF receptor superfamily, member 6) 153 AC004770 FADS3 fatty acid desaturase 3 154 Z70519 FAS Fas (TNF receptor superfamily, member 6) 155 AF107846 GNAS GNAS complex locus 156 collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) L23982 COL7A1 157 AJ276888 MDM2 Mdm2 p53 binding protein homolog (mouse) 158 BE888744 IFIT2 interferon-induced protein with tetratricopeptide repeats 2 159 BE930512 MGC5370 Hypothetical protein MGC5370 160 NM_000064 C3 complement component 3 161 NM_022772 EPS8L2 EPS8-like 2 162 NM_014454 SESN1 sestrin 1 163 THSD1 /// thrombospondin, type I, domain containing 1 /// NM_018676 THSD1P thrombospondin, type I, domain containing 1 pseudogene 164 NM_004669 CLIC3 chloride intracellular channel 3 165 NM_016321 RHCG Rh family, C glycoprotein 166 NM_015900 PLA1A phospholipase A1 member A 167 NM_022470 ZMAT3 zinc finger, matrin type 3 168 NM_024728 C7orf10 chromosome 7 open reading frame 10 169 NM_017938 FAM70A family with sequence similarity 70, member A 170 NM_017986 GPR172B G protein-coupled receptor 172B 171 AL136861 CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 172 AF133207 HSPB8 heat shock 22kDa protein 8 173 AL537457 NEFL neurofilament, light polypeptide 68kDa 174 BF055311 NEFL neurofilament, light polypeptide 68kDa 175 HNRNPA1 /// LOC728844 heterogeneous nuclear ribonucleoprotein A1 /// hypothetical LOC728844 AW450929 176 BF131886 SESN2 sestrin 2 177 AB056106 ABI3BP ABI gene family, member 3 (NESH) binding protein 178 AL136680 GBP3 guanylate binding protein 3 179 AL136826 RGMA RGM domain family, member A 180 AF160477 PVRL4 poliovirus receptor-related 4 181 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) AF113016 MALAT1 182 BF062193 CYorf15B chromosome Y open reading frame 15B 183 AF329088 OSAP ovary-specific acidic protein 184 AF229179 TMEM27 transmembrane protein 27 185 AF132202 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 103
CHAPTER 3 RESULTS 186 BC006355 PLCD4 phospholipase C, delta 4 187 AI446756 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 188 AF001540 MALAT1 metastasis associated lung adenocarcinoma transcript 1 189(non-protein coding) 189 BE675516 TncRNA trophoblast-derived noncoding RNA 190 AI042152 TncRNA trophoblast-derived noncoding RNA 191 BG534952 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 192 AW005982 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 193 AL133001 SULF2 sulfatase 2 194 AI952357 MGC5370 hypothetical protein MGC5370 195 AI355441 --- CDNA FLJ26120 fis, clone SYN00419 196 N21643 --- CDNA FLJ39585 fis, clone SKMUS2006633 197 N21426 SYTL2 synaptotagmin-like 2 198 AI601101 FAM84A /// LOC653602 family with sequence similarity 84, member A /// hypothetical LOC653602 199 AW006123 FBXO32 F-box protein 32 200 AL039862 FAM84B family with sequence similarity 84, member B 201 AW341649 TP53INP1 tumor protein p53 inducible nuclear protein 1 202 N21030 NRBP2 nuclear receptor binding protein 2 203 AB033041 VANGL2 vang-like 2 (van gogh, Drosophila) 204 N32834 GLIPR1 GLI pathogenesis-related 1 (glioma) 205 AV682252 GLIPR1 GLI pathogenesis-related 1 (glioma) 206 BE217880 IL7R interleukin 7 receptor 207 BE967311 MCC mutated in colorectal cancers 208 AI565067 KIAA1324 KIAA1324 209 AI188653 MXD1 MAX dimerization protein 1 210 AW117717 AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) 211 AI446414 KITLG KIT ligand 212 AL513673 CYGB cytoglobin 213 AI986239 AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) 214 W80468 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 215 AA131041 IFIT2 interferon-induced protein with tetratricopeptide repeats 2 216 AI571166 --- CDNA FLJ39306 fis, clone OCBBF2013123 217 AU155361 TncRNA trophoblast-derived noncoding RNA 218 AA524669 LOC1001315 64 hypothetical protein LOC100131564 219 AI343467 --- CDNA FLJ11041 fis, clone PLACE1004405 220 N36085 --- CDNA clone IMAGE:5261213 104
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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CHAPTER 1 INTRODUCTION At the prese
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Page 66 and 67: CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69: CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
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Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
Page 160 and 161: CHAPTER 3 RESULTS (7.5±0.64) (Fig.
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CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
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CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
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CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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