LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS 80 NM_002185 IL7R interleukin 7 receptor 81 NM_016352 CPA4 carboxypeptidase A4 82 NM_014668 GREB1 GREB1 protein 83 GABBR1 /// NM_006398 UBD 84 NM_005393 PLXNB3 plexin B3 85 NM_001086 AADAC arylacetamide deacetylase (esterase) 86 NM_001941 DSC3 desmocollin 3 87 NM_003265 TLR3 toll-like receptor 3 88 NM_005531 IFI16 interferon, gamma-inducible protein 16 gamma-aminobutyric acid (GABA) B receptor, 1 /// ubiquitin D 89 carcinoembryonic antigen-related cell adhesion molecule NM_001712 CEACAM1 1 (biliary glycoprotein) 90 NM_015364 LY96 lymphocyte antigen 96 91 NM_003811 TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 92 NM_001974 EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 93 NM_001561 TNFRSF9 tumor necrosis factor receptor superfamily, member 9 94 NM_001531 MR1 major histocompatibility complex, class I-related 95 NM_001531 MR1 major histocompatibility complex, class I-related 96 NM_013314 BLNK B-cell linker 97 NM_004110 FDXR ferredoxin reductase 98 SAA1 /// NM_030754 SAA2 serum amyloid A1 /// serum amyloid A2 99 AF204231 GOLGA8A golgi autoantigen, golgin subfamily a, 8A 100 AF208043 IFI16 interferon, gamma-inducible protein 16 101 AF247168 C1orf63 chromosome 1 open reading frame 63 102 AF007162 CRYAB crystallin, alpha B 103 BC001743 C7orf44 chromosome 7 open reading frame 44 104 AF237813 ABAT 4-aminobutyrate aminotransferase 105 AF237813 ABAT 4-aminobutyrate aminotransferase 106 X16354 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 107 DNA segment on chromosome 4 (unique) 234 expressed NM_014392 D4S234E sequence 108 DNA segment on chromosome 4 (unique) 234 expressed BC001745 D4S234E sequence 109 BC001422 PGF placental growth factor 110 M87507 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 111 M15329 IL1A interleukin 1, alpha 112 AF010446 MR1 major histocompatibility complex, class I-related 113 AF031469 MR1 major histocompatibility complex, class I-related 114 M11734 CSF2 colony stimulating factor 2 (granulocyte-macrophage) 115 AB007458 TP53AP1 TP53 activated protein 1 101
CHAPTER 3 RESULTS 116 L76224 GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 117 AF164622 GOLGA8A /// GOLGA8B golgi autoantigen, golgin subfamily a, 8A /// golgi autoantigen, golgin subfamily a, 8B 118 M13436 INHBA inhibin, beta A 119 AF119863 MEG3 maternally expressed 3 120 AF063612 OASL 2'-5'-oligoadenylate synthetase-like 121 AF064771 DGKA diacylglycerol kinase, alpha 80kDa 122 U13698 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 123 caspase 1, apoptosis-related cysteine peptidase 124 U13699 CASP1 (interleukin 1, beta, convertase) caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) U13700 CASP1 125 AF186255 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 126 U20489 PTPRO protein tyrosine phosphatase, receptor type, O 127 AF201370 MDM2 Mdm2 p53 binding protein homolog (mouse) 128 129 130 M76742 D12502 CEACAM1 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 AL541302 SERPINE2 131 AI762552 HNRPDL Heterogeneous nuclear ribonucleoprotein D-like 132 AI130920 PABPN1 poly(A) binding protein, nuclear 1 133 AW052179 COL4A5 collagen, type IV, alpha 5 (Alport syndrome) 134 AI572079 SNAI2 snail homolog 2 (Drosophila) 135 AA083478 TRIM22 tripartite motif-containing 22 136 AL050154 KIAA1462 KIAA1462 137 Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) W74620 HNRNPD 138 AU155515 RPL37A ribosomal protein L37a 139 AW103422 PCBP2 poly(rC) binding protein 2 140 AA554945 --- Transcribed locus 141 AL037167 RABL4 RAB, member of RAS oncogene family-like 4 142 AI912583 GLIPR1 GLI pathogenesis-related 1 (glioma) 143 ATP synthase, H+ transporting, mitochondrial F1 BG232034 ATP5C1 complex, gamma polypeptide 1 144 X90579 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 145 X90579 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 146 AI962377 LOC729222 /// PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) /// similar to mKIAA1230 protein 147 NM_006417 IFI44 interferon-induced protein 44 148 M23699 SAA1 /// serum amyloid A1 /// serum amyloid A2 102
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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CHAPTER 1 INTRODUCTION damage must
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Page 66 and 67: CHAPTER 1 INTRODUCTION hypersensiti
Page 68 and 69: CHAPTER 1 INTRODUCTION cycle-specif
Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
Page 86 and 87: CHAPTER 1 INTRODUCTION becomes pote
Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 108 and 109: CHAPTER 3 RESULTS Table 3.1.2A List
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
Page 158 and 159: CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
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CHAPTER 3 RESULTS (7.5±0.64) (Fig.
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CHAPTER 3 RESULTS Fig.3.3.1.6 Phosp
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CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
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CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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12 S. Ghosh et al. / Mutation Resea
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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