LIFE01200604005 Shri Somnath Ghosh - Homi Bhabha National ...

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CHAPTER 3 RESULTS Table 3.1.2A List of Up-regulated Genes: Control Vs 5X2Gy S.No Public ID Gene Symbol Gene Title 1 M21121 CCL5 chemokine (C-C motif) ligand 5 2 NM_153838 GPR115 G protein-coupled receptor 115 3 NM_134268 CYGB cytoglobin 4 NM_005764 PDZK1IP1 PDZK1 interacting protein 1 5 BC021286 C1orf187 chromosome 1 open reading frame 187 6 AF355465 ZMAT3 zinc finger, matrin type 3 7 AB014766 --- --- 8 AF043341 CCL5 chemokine (C-C motif) ligand 5 9 AK094613 RPS24 Ribosomal protein S24 10 AI332397 EIF4A2 eukaryotic translation initiation factor 4A, isoform 2 11 AA580691 RBM25 RNA binding motif protein 25 12 BC039509 LOC643401 hypothetical protein LOC643401 13 BC007947 PHLDB3 pleckstrin homology-like domain, family B, member 3 14 BG389789 --- --- 15 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) BE708432 MALAT1 16 AK090412 LOC375010 hypothetical LOC375010 17 BC040303 LOC727916 hypothetical protein LOC727916 18 BC043411 --- Homo sapiens, clone IMAGE:6155889, mRNA 19 AL832227 BCL8 B-cell CLL/lymphoma 8 20 AL832227 BCL8 B-cell CLL/lymphoma 8 21 AF086134 --- Full length insert cDNA clone ZA88B06 22 AF147425 SF3B14 Splicing factor 3B, 14 kDa subunit 23 AK098337 LOC375010 hypothetical LOC375010 24 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 BC020765 SERPINE1 25 BC017771 CCDC90B coiled-coil domain containing 90B 26 BC018787 MGC59937 Similar to RIKEN cDNA 2310002J15 gene 27 BC023629 PDLIM7 PDZ and LIM domain 7 (enigma) 28 BC023629 PDLIM7 PDZ and LIM domain 7 (enigma) 29 BC041011 EME2 essential meiotic endonuclease 1 homolog 2 (S. pombe) 30 NM_001613 ACTA2 actin, alpha 2, smooth muscle, aorta 31 BG339064 BTG2 BTG family, member 2 32 NM_006763 BTG2 BTG family, member 2 33 BF111821 WSB1 WD repeat and SOCS box-containing 1 34 BG491844 JUN jun oncogene 35 NM_002228 JUN jun oncogene 36 NM_002276 KRT19 keratin 19 37 NM_006762 LAPTM5 lysosomal associated multispanning membrane protein 5 38 NM_002462 MX1 myxovirus (influenza virus) resistance 1, interferoninducible protein p78 (mouse) 99
CHAPTER 3 RESULTS 39 NM_014734 KIAA0247 KIAA0247 40 NM_005562 LAMC2 laminin, gamma 2 41 NM_002615 SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 42 NM_000389 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 43 NM_001710 CFB complement factor B 44 NM_001674 ATF3 activating transcription factor 3 45 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) NM_000029 AGT 46 NM_014905 GLS glutaminase 47 NM_005541 INPP5D inositol polyphosphate-5-phosphatase, 145kDa 48 NM_001345 DGKA diacylglycerol kinase, alpha 80kDa 49 NM_005502 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 50 NM_005103 FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 51 NM_001924 GADD45A growth arrest and DNA-damage-inducible, alpha 52 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 NM_004267 CHST2 53 NM_004585 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 54 NM_006851 GLIPR1 GLI pathogenesis-related 1 (glioma) 55 NM_021127 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 56 NM_000229 LCAT lecithin-cholesterol acyltransferase 57 NM_000698 ALOX5 arachidonate 5-lipoxygenase 58 NM_004961 GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 59 NM_002985 CCL5 chemokine (C-C motif) ligand 5 60 NM_001549 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 61 AA164751 FAS Fas (TNF receptor superfamily, member 6) 62 NM_000043 FAS Fas (TNF receptor superfamily, member 6) 63 NM_004165 RRAD Ras-related associated with diabetes 64 NM_004165 RRAD Ras-related associated with diabetes 65 NM_006307 SRPX sushi-repeat-containing protein, X-linked 66 NM_000203 IDUA iduronidase, alpha-L- 67 NM_000576 IL1B interleukin 1, beta 68 AB046692 AOX1 aldehyde oxidase 1 69 NM_001159 AOX1 aldehyde oxidase 1 70 NM_000600 IL6 interleukin 6 (interferon, beta 2) 71 AF026303 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 72 NM_002392 MDM2 Mdm2 p53 binding protein homolog (mouse) 73 NM_005101 ISG15 ISG15 ubiquitin-like modifier 74 NM_005658 TRAF1 TNF receptor-associated factor 1 75 NM_001785 CDA cytidine deaminase 76 NM_000756 CRH corticotropin releasing hormone 77 NM_003733 OASL 2'-5'-oligoadenylate synthetase-like 78 NM_000777 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 79 NM_001197 BIK BCL2-interacting killer (apoptosis-inducing) 100
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RADIATION INDUCED SIGNALING IN MAMM
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DECLARATION I, hereby declare that
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CONTENTS Page No. SYNOPSIS………
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2.11 Measurement of NO production
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PREAMBLE SYNOPSIS Ionising radiatio
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SYNOPSIS Aims and Objectives: To St
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SYNOPSIS 2.6 Immunofluorescence sta
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SYNOPSIS ATM gene expression, which
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SYNOPSIS Percentage Survival 100 80
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SYNOPSIS Ratio of Rad52 to Actin Ra
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Relative Phosphorylation 45 40 35 3
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SYNOPSIS Fig. 3.3A Clonogenic Cell
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SYNOPSIS (A) Av No. of phospho BRCA
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SYNOPSIS Percentage Survival 120 10
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SYNOPSIS Fig.3.4B. Existance of cro
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SYNOPSIS Fig. 3.4EDNA damage in EL-
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SYNOPSIS subsequent cytotoxicity ca
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SYNOPSIS [4] Hall, E. J. Radiobiolo
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CHAPTER 1 INTRODUCTION INTRODUCTION
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CHAPTER 1 INTRODUCTION 15.8% 9.56%
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CHAPTER 1 INTRODUCTION far apart an
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CHAPTER 1 INTRODUCTION and are more
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CHAPTER 1 INTRODUCTION 1.3 DNA dama
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CHAPTER 1 INTRODUCTION associates w
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CHAPTER 1 INTRODUCTION are unable t
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CHAPTER 1 INTRODUCTION Perhaps one
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CHAPTER 1 INTRODUCTION occurs at DS
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CHAPTER 1 INTRODUCTION related prot
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Page 66 and 67: CHAPTER 1 INTRODUCTION hypersensiti
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Page 70 and 71: CHAPTER 1 INTRODUCTION 1.4 Overview
Page 72 and 73: CHAPTER 1 INTRODUCTION 1.4.1 Radiat
Page 74 and 75: CHAPTER 1 INTRODUCTION interaction
Page 76 and 77: CHAPTER 1 INTRODUCTION p90S6 kinase
Page 78 and 79: CHAPTER 1 INTRODUCTION CD4 (formerl
Page 80 and 81: CHAPTER 1 INTRODUCTION unrepaired d
Page 82 and 83: CHAPTER 1 INTRODUCTION well to the
Page 84 and 85: CHAPTER 1 INTRODUCTION 1.6 Radiatio
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Page 88 and 89: CHAPTER 2 MATERIALS AND METHODS MAT
Page 90 and 91: CHAPTER 2 MATERIALS AND METHODS 2.2
Page 92 and 93: CHAPTER 2 MATERIALS AND METHODS res
Page 94 and 95: CHAPTER 2 MATERIALS AND METHODS Arr
Page 96 and 97: CHAPTER 2 MATERIALS AND METHODS PBS
Page 98 and 99: CHAPTER 2 MATERIALS AND METHODS the
Page 100 and 101: CHAPTER 2 MATERIALS AND METHODS 2.1
Page 102 and 103: CHAPTER 3 RESULTS RESULTS 93
Page 104 and 105: CHAPTER 3 RESULTS fractionated regi
Page 106 and 107: CHAPTER 3 RESULTS On comparison of
Page 110 and 111: CHAPTER 3 RESULTS 80 NM_002185 IL7R
Page 112 and 113: CHAPTER 3 RESULTS SAA2 149 AU134977
Page 114 and 115: CHAPTER 3 RESULTS 221 LOC643167 RNA
Page 116 and 117: CHAPTER 3 RESULTS 299 BF244402 FBXO
Page 118 and 119: CHAPTER 3 RESULTS CDK4) 57 AU152107
Page 120 and 121: CHAPTER 3 RESULTS 134 AL045793 METT
Page 122 and 123: CHAPTER 3 RESULTS 58 AF237813 ABAT
Page 124 and 125: CHAPTER 3 RESULTS 127 AI809749 ORMD
Page 126 and 127: CHAPTER 3 RESULTS 31 BE615699 UNC84
Page 128 and 129: CHAPTER 3 RESULTS 47 AF026303 SULT1
Page 130 and 131: CHAPTER 3 RESULTS 117 BF062193 CYor
Page 132 and 133: CHAPTER 3 RESULTS 187 AL036662 ---
Page 134 and 135: CHAPTER 3 RESULTS 52 AV686514 EMP2
Page 136 and 137: CHAPTER 3 RESULTS exposed to 10 Gy
Page 138 and 139: CHAPTER 3 RESULTS Fig.3.1.4 Gene ex
Page 140 and 141: CHAPTER 3 RESULTS Fig. 3.1.6 Radiat
Page 142 and 143: CHAPTER 3 RESULTS Fig. 3.1.7 Transl
Page 144 and 145: CHAPTER 3 RESULTS 3.1.9 Stabilizati
Page 146 and 147: CHAPTER 3 RESULTS 23±1.5% (Fig. 3.
Page 148 and 149: CHAPTER 3 RESULTS whereas only the
Page 154 and 155: CHAPTER 3 RESULTS with equal doses
Page 156 and 157: CHAPTER 3 RESULTS Fig.3.3.1.2 Forma
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CHAPTER 3 RESULTS Fig.3.3.1.3 Phosp
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CHAPTER 3 RESULTS (7.5±0.64) (Fig.
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CHAPTER 3 RESULTS Fig.3.3.1.7b Phos
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CHAPTER 3 RESULTS 3.3.2 Oxygen beam
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CHAPTER 3 RESULTS in all the cells.
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CHAPTER 3 RESULTS 3.3.2.3 Radiation
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CHAPTER 3 RESULTS Fig.3.3.2.7 Apopt
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CHAPTER 3 RESULTS PMA stimulated U9
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CHAPTER 3 RESULTS Fig.3.4.2. Exista
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CHAPTER 3 RESULTS up-regulation of
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CHAPTER 3 RESULTS Fig.3.4.3.2 NO pr
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CHAPTER 3 RESULTS 3.4.3.4 Apoptotic
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CHAPTER 3 RESULTS 3.4.4 Bystander e
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CHAPTER 3 RESULTS Fig.3.4.4b DNA da
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CHAPTER 3 RESULTS Fig.3.4.5a Gene e
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CHAPTER 4 DISCUSSION DISCUSSION 185
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CHAPTER 4 DISCUSSION directly expos
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CHAPTER 4 DISCUSSION dose is delive
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CHAPTER 4 DISCUSSION A clear cause
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CHAPTER 4 DISCUSSION 4.2 Proton bea
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CHAPTER 4 DISCUSSION Although the e
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CHAPTER 4 DISCUSSION Similar number
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CHAPTER 4 DISCUSSION the mechanism
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CHAPTER 4 DISCUSSION Thus unlike th
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CHAPTER 4 DISCUSSION different from
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CHAPTER 4 DISCUSSION upregulates ma
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CHAPTER 4 DISCUSSION Numerous studi
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CHAPTER 4 DISCUSSION inhibition of
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CHAPTER 4 DISCUSSION The survival o
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CHAPTER 5 REFERENCES [1] Khan, F. T
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CHAPTER 5 REFERENCES [19] Woo, R. A
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CHAPTER 5 REFERENCES [35] Nghiem, P
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CHAPTER 5 REFERENCES [52] McKay, B.
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CHAPTER 5 REFERENCES [69] Cary, R.
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CHAPTER 5 REFERENCES [84] Uziel, T.
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CHAPTER 5 REFERENCES [98] Liu, Y.;
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CHAPTER 5 REFERENCES [111] Fei, P.;
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CHAPTER 5 REFERENCES [127] Frank, K
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CHAPTER 5 REFERENCES [141] Pierce,
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CHAPTER 5 REFERENCES [156] Roots, R
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CHAPTER 5 REFERENCES [171] Xia, Z.;
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CHAPTER 5 REFERENCES (MAP) kinase c
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CHAPTER 5 REFERENCES phosphorylatio
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CHAPTER 5 REFERENCES [211] Anderson
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CHAPTER 5 REFERENCES [229] Konca, K
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CHAPTER 5 REFERENCES [245] Kastan,
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CHAPTER 5 REFERENCES [261] Miralbel
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CHAPTER 5 REFERENCES [278] Weizman,
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CHAPTER 5 REFERENCES [294] Zhou, H.
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PUBLICATIONS AND PRESENTATIONS Publ
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Mutation Research 729 (2012) 61-72
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S. Ghosh, M. Krishna / Mutation Res
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Cancer Invest Downloaded from infor
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1568 I. J. Radiation Oncology d Bio
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