LIFE09200604007 Tabish - Homi Bhabha National Institute
LIFE09200604007 Tabish - Homi Bhabha National Institute
LIFE09200604007 Tabish - Homi Bhabha National Institute
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Results<br />
Fig. 31: Percent cell death after BPDE exposure in MPN (n=20) and control cell lines (n=10).<br />
Percent cell death after 5μM radiation exposure (a) percent cell death after 8μM radiation exposure (b).<br />
Mean difference between percent relative cell death between MPN and control cell lines was statistically<br />
significant (p=0.0009 at 5μM and p=0.0008 at 8μM). The values shown are the mean values from three<br />
separate experiments.<br />
Table 12: Average cell death after γ-radiation and BPDE exposure in MPN and control cell lines<br />
Genotoxic<br />
exposure<br />
Dose/concent<br />
ration<br />
MPN cell line (n=20)<br />
Control cell line (n=10)<br />
Radiation exposure<br />
5 Gy<br />
10 Gy<br />
9.84%<br />
(Range 8.3% - 12.7%)<br />
10.84%<br />
(Range 8.3% - 12.7%)<br />
19.22%<br />
(Range 9.05% - 42.82%)<br />
22.09%<br />
(Range 12.04% - 42.4%)<br />
BPDE treatment<br />
5 µM 13.57%<br />
(Range 8.02% - 21.77%)<br />
8 µM 14.02%<br />
(Range 8.46% - 24.69%)<br />
23.25%<br />
(Range 10.49% - 41.79%)<br />
24.98%<br />
(Range 10.23% - 51.76%)<br />
114