Prof. Dr. Michael Brunner Heidelberg University ... - HBIGS

Prof. Dr. Michael Brunner
Heidelberg University Biochemistry Center (BZH)
69120 Heidelberg
Phone: +49-6221 54-4207
Fax:: +49-6221 54-4769
E-mail: michael.brunner@urz.uni-heidelberg.de
26/07/1957, Waibstadt
CURRICULUM VITAE
2003 – 2005 Dean of the Faculty of Biosciences
2000 – present Professor (C4) University of Heidelberg Biochemistry Center
1998 – 2000 Professor (C3) Ludwig-Maximilians-University (LMU), Munich
1998 Habilitation (Medical Faculty) LMU, Munich
1992 – 1998 Group leader at the Institute of Physiological Chemistry LMU, Munich
1989 – 1991 Post doctoral fellow with Dr. J. E. Rothman, Princeton University and
Sloan-Kettering Institute, New York
1984 – 1988 PhD, “summa cum laude”, ZMBH and Hoffman LaRoche, Basel
1984 Biology Diploma ”mit Auszeichnung bestanden”, University of Heidelberg
HONORS
2004 EMBO Membership
1990 - 1991 European Molecular Biology Organization (EMBO)
1989 Deutscher Akademischer Austauschdienst (DAAD)
FIELDS OF INTEREST
Circadian rhythm and molecular clock of Neurospora crassa, gene regulation by light and
temperature.
CURRENTLY FUNDED PROJECTS
SFB 638 project B4, GK1188, DFG BR1375/2.

PUBLICATIONS (10 most important publications):
Schafmeier T, Káldi K, Diernfellner A, Mohr CA, Brunner M (2006) Phosphorylation
dependent maturation of Neurospora circadian clock protein from a nuclear repressor
towards a cytoplasmic activator. Genes & Dev 20: 297-306.
Káldi K, Herreros González B, Brunner M (2006) A positive feedback loop of the Neurospora
circadian clock gene wc-1 modulates the phase of circadian output. EMBO reports 7: 199-
204.
Diernfellner ACR, Schafmeier T, Merrow MW, Brunner M (2005) Molecular mechanism of
temperature sensing by the circadian clock of Neurospora crassa. Genes & Dev 19: 1968-
1973.
Schafmeier T, Haase A, Káldi K, Scholz J, Fuchs, M, Brunner M (2005) Transcriptional
feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of
its transcription factor. Cell 122: 235-246.
Goerl M, Merrow M, Huttner B, Johnson J, Roenneberg T, Brunner M (2001) A PEST-like
element in FREQUENCY determines the length of the circadian period in Neurospora
crassa. EMBO J. 20: 7074-7084.
Donzeau M, Káldi K, Adam A, Wanner G, Guiard B, Bauer MF, Neupert W, Brunner, M
(2000) Protein translocation contact sites between outer and inner membranes of
mitochondria. Cell 101: 401-412.
Sirrenberg C, Endres M, Fölsch H, Stuart RA, Neupert W, Brunner M (1998) Carrier protein
import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and
Tim12/Mrs5. Nature 391: 912-915.
Bauer MF, Sirrenberg C, Neupert W, Brunner M (1996) Role of Tim23 as voltage sensor and
presequence receptor in protein import into mitochondria. Cell 87: 33-41.
Sirrenberg C, Bauer MF, Guiard B, Neupert W, Brunner M (1996) Import of carrier proteins
into the mitochondrial inner membrane mediated by Tim22. Nature 384: 582-585.
Berthold J, Bauer MF, Schneider HC, Klaus C, Dietmeier K, Neupert W, Brunner M (1995)
The MIM complex mediates preprotein translocation across the mitochondrial inner
membrane and couples it to the mt-Hsp70/ATP driving system. Cell 81: 1085-1093.
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EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous Thesis Advisory and Thesis Defense Committees
Total Number of supervised PhDs: 16
SUPERVISED DISSERTATIONS (last 5 years):
Axel Diernfellner, PhD (2006) Temperaturperzeption der circadianen Uhr von Neurospora
rassa durch posttranskriptionelle Modulation des zentralen Oszillatorproteins
FREQUENCY
Current occupation: Postdoctoral fellow
Andrea Haase, PhD (2005) Untersuchung zur Interaktion der Uhrenproteine FRQ, WC-1,
WC-2 in Neurospora crassa
Current occupation: Postdoctoral fellow
Tobias Schafmeier, PhD (2005) Funktionen des molekularen Uhrenproteins FREQUENCY in
Cytosol und Zellkern
Current occupation: Postdoctoral fellow
Görl Margit, PhD (2002) Molekulare Mechanismen der circadianen Uhr in Neurospora crassa
Current occupation: Quiagen
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