Prof. Dr. Michael Brunner Heidelberg University ... - HBIGS
Prof. Dr. Michael Brunner Heidelberg University ... - HBIGS
Prof. Dr. Michael Brunner Heidelberg University ... - HBIGS
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<strong>Prof</strong>. <strong>Dr</strong>. <strong>Michael</strong> <strong>Brunner</strong><br />
<strong>Heidelberg</strong> <strong>University</strong> Biochemistry Center (BZH)<br />
69120 <strong>Heidelberg</strong><br />
Phone: +49-6221 54-4207<br />
Fax:: +49-6221 54-4769<br />
E-mail: michael.brunner@urz.uni-heidelberg.de<br />
26/07/1957, Waibstadt<br />
CURRICULUM VITAE<br />
2003 – 2005 Dean of the Faculty of Biosciences<br />
2000 – present <strong>Prof</strong>essor (C4) <strong>University</strong> of <strong>Heidelberg</strong> Biochemistry Center<br />
1998 – 2000 <strong>Prof</strong>essor (C3) Ludwig-Maximilians-<strong>University</strong> (LMU), Munich<br />
1998 Habilitation (Medical Faculty) LMU, Munich<br />
1992 – 1998 Group leader at the Institute of Physiological Chemistry LMU, Munich<br />
1989 – 1991 Post doctoral fellow with <strong>Dr</strong>. J. E. Rothman, Princeton <strong>University</strong> and<br />
Sloan-Kettering Institute, New York<br />
1984 – 1988 PhD, “summa cum laude”, ZMBH and Hoffman LaRoche, Basel<br />
1984 Biology Diploma ”mit Auszeichnung bestanden”, <strong>University</strong> of <strong>Heidelberg</strong><br />
HONORS<br />
2004 EMBO Membership<br />
1990 - 1991 European Molecular Biology Organization (EMBO)<br />
1989 Deutscher Akademischer Austauschdienst (DAAD)<br />
FIELDS OF INTEREST<br />
Circadian rhythm and molecular clock of Neurospora crassa, gene regulation by light and<br />
temperature.<br />
CURRENTLY FUNDED PROJECTS<br />
SFB 638 project B4, GK1188, DFG BR1375/2.
PUBLICATIONS (10 most important publications):<br />
Schafmeier T, Káldi K, Diernfellner A, Mohr CA, <strong>Brunner</strong> M (2006) Phosphorylation<br />
dependent maturation of Neurospora circadian clock protein from a nuclear repressor<br />
towards a cytoplasmic activator. Genes & Dev 20: 297-306.<br />
Káldi K, Herreros González B, <strong>Brunner</strong> M (2006) A positive feedback loop of the Neurospora<br />
circadian clock gene wc-1 modulates the phase of circadian output. EMBO reports 7: 199-<br />
204.<br />
Diernfellner ACR, Schafmeier T, Merrow MW, <strong>Brunner</strong> M (2005) Molecular mechanism of<br />
temperature sensing by the circadian clock of Neurospora crassa. Genes & Dev 19: 1968-<br />
1973.<br />
Schafmeier T, Haase A, Káldi K, Scholz J, Fuchs, M, <strong>Brunner</strong> M (2005) Transcriptional<br />
feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of<br />
its transcription factor. Cell 122: 235-246.<br />
Goerl M, Merrow M, Huttner B, Johnson J, Roenneberg T, <strong>Brunner</strong> M (2001) A PEST-like<br />
element in FREQUENCY determines the length of the circadian period in Neurospora<br />
crassa. EMBO J. 20: 7074-7084.<br />
Donzeau M, Káldi K, Adam A, Wanner G, Guiard B, Bauer MF, Neupert W, <strong>Brunner</strong>, M<br />
(2000) Protein translocation contact sites between outer and inner membranes of<br />
mitochondria. Cell 101: 401-412.<br />
Sirrenberg C, Endres M, Fölsch H, Stuart RA, Neupert W, <strong>Brunner</strong> M (1998) Carrier protein<br />
import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and<br />
Tim12/Mrs5. Nature 391: 912-915.<br />
Bauer MF, Sirrenberg C, Neupert W, <strong>Brunner</strong> M (1996) Role of Tim23 as voltage sensor and<br />
presequence receptor in protein import into mitochondria. Cell 87: 33-41.<br />
Sirrenberg C, Bauer MF, Guiard B, Neupert W, <strong>Brunner</strong> M (1996) Import of carrier proteins<br />
into the mitochondrial inner membrane mediated by Tim22. Nature 384: 582-585.<br />
Berthold J, Bauer MF, Schneider HC, Klaus C, Dietmeier K, Neupert W, <strong>Brunner</strong> M (1995)<br />
The MIM complex mediates preprotein translocation across the mitochondrial inner<br />
membrane and couples it to the mt-Hsp70/ATP driving system. Cell 81: 1085-1093.<br />
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EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES<br />
Member of numerous Thesis Advisory and Thesis Defense Committees<br />
Total Number of supervised PhDs: 16<br />
SUPERVISED DISSERTATIONS (last 5 years):<br />
Axel Diernfellner, PhD (2006) Temperaturperzeption der circadianen Uhr von Neurospora<br />
rassa durch posttranskriptionelle Modulation des zentralen Oszillatorproteins<br />
FREQUENCY<br />
Current occupation: Postdoctoral fellow<br />
Andrea Haase, PhD (2005) Untersuchung zur Interaktion der Uhrenproteine FRQ, WC-1,<br />
WC-2 in Neurospora crassa<br />
Current occupation: Postdoctoral fellow<br />
Tobias Schafmeier, PhD (2005) Funktionen des molekularen Uhrenproteins FREQUENCY in<br />
Cytosol und Zellkern<br />
Current occupation: Postdoctoral fellow<br />
Görl Margit, PhD (2002) Molekulare Mechanismen der circadianen Uhr in Neurospora crassa<br />
Current occupation: Quiagen<br />
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