PD Dr. Oliver T. Fackler Department of Virology University ... - HBIGS

PUBLICATIONS (10 most important publications):
Haller C, Rauch S, Michel N, Hannemann S, Keppler OT, Fackler OT (2006) The HIV-1
pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by
modulation of N-Wasp activity. J Biol Chem 281: 19618-19630.
Keppler OT, Tibroni N, Venzke S, Rauch S, Fackler OT (2006) Modulation of Specific
Surface Receptors and Activation Sensitization in Resting Primary CD4+ T-Lymphocytes by
the Nef Protein of HIV 1. J Leukoc Biol 79: 616-627.
Michel N, Allespach I, Venzke S, Fackler OT*, Keppler OT* (2005) HIV Nef induces
superinfection immunity by a dual strategy to downregulate cell surface CCR5 and CD4. (*
corresponding authors). Curr Biol 15: 714-723.
Krautkrämer E, Giese SI, Gasteier JE, Muranyi W, Fackler OT (2004) HIV-1 Nef activates
Pak via recruitment into lipid rafts. J Virol 78: 4085-4097
Gasteier JE, Madrid R, Krautkrämer E, Schröder S, Muranyi W, Benichou S, Fackler OT
(2003) Activation of the Rac interaction partner formin homology 2 domain containing 1
(FHOD1) induces actin stress fibers via a ROCK dependent mechanism. J Biol Chem 278:
38902-38912.
Fackler OT, Baur AS (2002) Live and let die: Functions of Nef beyond HIV replication.
Immunity 16: 493-497.
Fackler OT, Wolf D, Weber HO, Laffert B, D’Aloja P, Schuler-Thurner B, Geffin R, Saksela K,
Geyer M, Peterlin BM, Schuler G, Baur AS (2001) A natural variability in the proline-rich motif
of Nef modulates HIV-1 replication in primary T-cells. Curr Biol 11: 1294-1299.
Fackler OT, Peterlin BM (2000) Endocytic entry of HIV-1. Curr Biol 10: 1005-1008.
Fackler OT, Lu X, Frost JA, Geyer M, Jiang B, Luo W, Abo A, Alberts AS, Peterlin BM (2000)
Pak1 plays a critical role in cellular activation by Nef. Mol Cell Biol 20: 2619-2627. [cover
titel]
Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM (1999) Activation of Vav by Nef
induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 3: 729-
739.