PD Dr. Oliver T. Fackler Department of Virology University ... - HBIGS

PD Dr. Oliver T. Fackler
Department of Virology
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-56 5007
Fax: +49-(0)6221-56 5003
Email : oliver.fackler@med.uni-heidelberg.de
23/05/1970, Dudweiler/Saar
CURRICULUM VITAE
2003 Habilitation in experimental virology, University of Heidelberg
2000 - present Group leader, Department of Virology, Heidelberg
1997 - 2000 PostDoc, Cancer Research Center, University of California at San
Francisco
1994 – 1997 PhD in molecular virology (Homburg/Saar)
1993 - 1994 Diploma thesis in molecular virology (Homburg/Saar)
1989 - 1993 Studies in biology (Saarbrücken)
COORDINATING FUNCTIONS
2005 - present Co-chair of graduate programme 1188 (“Quantitative Analysis of Dynamic
Processes in Membrane Transport and Translocation”), DFG
HONORS
2005 Group Leader Fellowship, C.H.S. Stiftung
2001 Emmy-Noether Fellowship, DFG
1999 Postdoctoral Fellowship, DFG
1997 Postdoctoral Fellowship, Howard Hughes Medical Institute
1998 “General Accident” Insurance Award for the best thesis in the Medical
Department of the University of the Saarland
FIELDS OF INTEREST
Molecular virology, cell biology of virus infection, actin dynamics and virus replication, T cell
receptor signal transduction, molecular biology of diaphanous related formins
CURRENTLY FUNDED PROJECTS
SFB638, project A11, TR 7013, project C4, GK1188, DFG project on the DRF FHOD1, DFG-
Fa 378/6-1

PUBLICATIONS (10 most important publications):
Haller C, Rauch S, Michel N, Hannemann S, Keppler OT, Fackler OT (2006) The HIV-1
pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by
modulation of N-Wasp activity. J Biol Chem 281: 19618-19630.
Keppler OT, Tibroni N, Venzke S, Rauch S, Fackler OT (2006) Modulation of Specific
Surface Receptors and Activation Sensitization in Resting Primary CD4+ T-Lymphocytes by
the Nef Protein of HIV 1. J Leukoc Biol 79: 616-627.
Michel N, Allespach I, Venzke S, Fackler OT*, Keppler OT* (2005) HIV Nef induces
superinfection immunity by a dual strategy to downregulate cell surface CCR5 and CD4. (*
corresponding authors). Curr Biol 15: 714-723.
Krautkrämer E, Giese SI, Gasteier JE, Muranyi W, Fackler OT (2004) HIV-1 Nef activates
Pak via recruitment into lipid rafts. J Virol 78: 4085-4097
Gasteier JE, Madrid R, Krautkrämer E, Schröder S, Muranyi W, Benichou S, Fackler OT
(2003) Activation of the Rac interaction partner formin homology 2 domain containing 1
(FHOD1) induces actin stress fibers via a ROCK dependent mechanism. J Biol Chem 278:
38902-38912.
Fackler OT, Baur AS (2002) Live and let die: Functions of Nef beyond HIV replication.
Immunity 16: 493-497.
Fackler OT, Wolf D, Weber HO, Laffert B, D’Aloja P, Schuler-Thurner B, Geffin R, Saksela K,
Geyer M, Peterlin BM, Schuler G, Baur AS (2001) A natural variability in the proline-rich motif
of Nef modulates HIV-1 replication in primary T-cells. Curr Biol 11: 1294-1299.
Fackler OT, Peterlin BM (2000) Endocytic entry of HIV-1. Curr Biol 10: 1005-1008.
Fackler OT, Lu X, Frost JA, Geyer M, Jiang B, Luo W, Abo A, Alberts AS, Peterlin BM (2000)
Pak1 plays a critical role in cellular activation by Nef. Mol Cell Biol 20: 2619-2627. [cover
titel]
Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM (1999) Activation of Vav by Nef
induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 3: 729-
739.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous thesis and thesis advisory committees
SUPERVISED DISSERTATIONS (last 5 years)
Simone Giese, PhD (2007) Membrane association and plasma membrane transport of HIV-1
Nef
Current occupation: postdoc
Ellen Krautkrämer, PhD (2005) Role of Lipid rafts for the activity of the HIV pathogenicity
factor Nef
Current occupation: postdoc
Judith Gasteier, PhD (2004) Cellular functions of the HIV-1 Nef binding partner FHOD1
Current occupation: Researcher in Biotech