Dr. Oliver Gruss Center for Molecular Biology Heidelberg ... - HBIGS

Dr. Oliver Gruss
Center for Molecular Biology Heidelberg (ZMBH)
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-54 6815
Fax: +49-(0)6221-54 5893
E-mail: o.gruss@zmbh.uni-heidelberg.de
13/10/1967, Münster
CURRICULUM VITAE
2003 - present Junior Group Leader at the ZMBH, University Heidelberg
1998 - 2003 Post-Doc at EMBL, Heidelberg (with Dr. Iain Mattaj)
1994 - 1998 PhD thesis at the ZMBH, University Heidelberg (with Prof. Dr. B.
Dobberstein)
1994 Biochemistry Diplom (Regensburg)
1989 - 1994 Study of Biochemistry (Regensburg)
FIELDS OF INTEREST
Cell Biology, Mechanism and Regulation of cell Division and cell cycle control, Ran
regulation of M-Phase and spindle assembly, spindle proteomics
CURRENTLY FUNDED PROJECTS
DFG Normalverfahren (2 PhD students), Bioquant Promotionskolleg (1 PhD student).
Currently supervision of 1 Bachelor thesis and 4 PhD theses

PUBLICATIONS (10 most important publications):
Dumont J, Petri S, Pellegrin F, Terret ME, Bohnsack MT, Rassinier P, Georget V, Kalab P,
Gruss OJ, and Verlhac MH. J. Cell Biol. in press.
Godl K*, Gruss OJ*, Eickhoff J, Wissing J, Blencke S, Weber M, Degen H, Brehmer D, Orfi L,
Horvath Z, Keri G, Muller S, Cotten M, Ullrich A, Daub H. (2005) Proteomic characterization
of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling.
Cancer Res. Aug 1;65(15):6919-26. *shared first authorship
Gruss OJ, Vernos I. (2004) The mechanism of spindle assembly: functions of Ran and its
target TPX2. J Cell Biol. Sep 27;166(7):949-55. Review.
Schatz CA, Santarella R, Hoenger A, Karsenti E, Mattaj IW, Gruss OJ, Carazo-Salas RE.
(2003) Importin alpha-regulated nucleation of microtubules by TPX2. EMBO J. May
1;22(9):2060-70.
Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, Sillje H, Karsenti, E, Mattaj IW,
Vernos I. (2002) Chromosome-induced microtubule assembly mediated by TPX2 is required
for spindle formation in HeLa cells. Nat Cell Biol. Nov;4(11):871-9.
Kufer TA, Sillje HH, Korner R, Gruss OJ, Meraldi P, Nigg EA. (2002) Human TPX2 is
required for targeting Aurora-A kinase to the spindle. J Cell Biol. Aug 19;158(4):617-23.
Hetzer M, Gruss OJ, Mattaj IW. (2002) The Ran GTPase as a marker of chromosome
position in spindle formation and nuclear envelope assembly. Nat Cell Biol. Jul;4(7):E177-
84. Review.
Carazo-Salas RE, Gruss OJ, Mattaj IW, Karsenti E. (2001) Ran-GTP coordinates regulation
of microtubule nucleation and dynamics during mitotic-spindle assembly. Nat Cell Biol.
Mar;3(3):228-34.
Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos
I, Karsenti E, Mattaj IW. (2001) Ran induces spindle assembly by reversing the inhibitory
effect of importin alpha on TPX2 activity. Cell. Jan 12;104(1):83-93.
Hetzer M, Bilbao-Cortes D, Walther TC, Gruss OJ, Mattaj IW. (2000) GTP hydrolysis by Ran
is required for nuclear envelope assembly. Mol Cell. Jun;5(6):1013-24.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of several TAC committees at DKFZ, BZH, EMBL and ZMBH
Currently 4 PhD students in the lab
SUPERVISED DISSERTATIONS (last 5 years)
none yet