Dr. Niels Grabe TIGA Center, BIOQUANT, University of ... - HBIGS

Dr. Niels Grabe
TIGA Center, BIOQUANT, University of Heidelberg
Institute of Medical Biometry and Informatics
University Hospital Heidelberg
69120 Heidelberg
Phone: ++49-(0)6221- 54 51248
Fax: ++49-(0)6221- 54 51482
Email:
URL:
niels.grabe@med.uni-heidelberg.de
http://tiga.bioquant.uni-heidelberg.de
9/07/1971, Braunschweig
CURRICULUM VITAE
Since 2008
BMBF Research Group Leader in FORSYS-PARTNER
Since 2007
Cofounder and head of Hamamatsu TIGA-Center (Tissue Imaging
and Analysis) in BIOQUANT, University Heidelberg
Since 2005
Head of systems biology/bioinformatics group, lecturer in medical
bioinformatics, University Hospital Heidelberg
2004 – 2005 Project leader, University Hospital Hamburg-Eppendorf and Center
for Bioinformatics, University Hamburg
2002 – 2004 Co-Founder of ageLab Pharma GmbH, Hamburg
2001 Post-doc, Institute for Hormone and Fertility Research at the
University Hospital Hamburg Eppendorf
1997 – 2001 Ph.D. in Bioinformatics at the Otto-von-Guericke, University
Magdeburg
1992 – 1997 Computer Science Studies at the Technical University Braunschweig
COORDINDATING FUNCTIONS
Co-Coordinator
Coordinator/Lecturer
MEDSYS Chronic Wounds
Major in bioinformatics in the master, bachelor and diploma “Medical
Informatics” in cooperation with Heilbronn University
Coordinator 1 st European Workshop on Tissue Imaging and Analysis 2009
HONORS
Innovationspreis Bioinformatik 1998, MTZ BIOQUANT Award for Systems Biology 2007
FIELDS OF INTEREST
Systems biology of tissues, biomedical informatics, quantitative histology, automated and
virtual microscopy, image processing, network reconstruction, multi-agent modeling,
epithelial homeostasis, gene regulation

CURRENTLY FUNDED PROJECTS
Several projects dedicated to the reconstruction of epithelial homeostasis in BMBF-FORSYS
Partner, BMBF-MEDSYS, BMBF-GERONTOSYS, BfR, as well as several industrial
cooperations (e.g. Hamamatsu Photonics, Procter and Gamble, Thermo Fisher).
PUBLICATIONS (10 most important publications)
S. Michel, A. Benner, M. Tariverdian, N. Wentzensen, P. Hoefler, T. Pommerencke, N.
Grabe, M. von Knebel Doeberitz and M. Kloor, High density of FOXP3-positive T cells
infiltrating colorectal cancers with microsatellite instability, Br J Cancer. 2008 Nov 4.
E. Mussig, T. Steinberg, S. Schulz, J. Spatz, J. Ulmer, N. Grabe, A. Kohl, G. Komposch, P.
Tomakidi. (2008), 18, 1-11. Connective Tissue Fibroblasts Established on Micropillar
Interfaces are Pivotal for Epithelial Tissue Morphogenesis, Advanced Functional Materials
N. Grabe, Virtual Microscopy in Systems Pathology, Pathologe, 08/2008
T. Steinberg, S. Schulz, J. P. Spatz, N. Grabe, A. Kohl, G. Komposch, P. Tomakidi. Early
Keratinocyte Differentiation on Micropillar Interfaces (2007), Nano Letters Feb; 7(2):287-94
T. Pommerencke, T. Steinberg, H. Dickhaus H, P. Tomakidi, N. Grabe (2008) Nuclear
staining and relative distance for quantifying epidermal differentiation in biomarker
expression profiling, BMC Bioinformatics 2008 Nov 6;9(1):473
N. Grabe, T. Pommerencke, P. Tomakidi, T. Steinberg, H. Dickhaus (2007): „ Reconstructing
protein networks of epithelial differentiation from histological sections”, Bioinformatics Dec
1; 23(23):3200-8.
N. Grabe, K. Neuber. Simulating psoriasis by altering transit amplifying cells.
Bioinformatics, (2007) Jun 1; 23(11):1309-12
N. Grabe, K. Neuber. A multi-cellular systems biology model predicts epidermal morphology,
kinetics, and Ca++ flow. Bioinformatics (2005) Sep 1;21(17):3541-7.
M. Koenig, N. Grabe. Highly-specific prediction of phosphorylation sites in proteins."
Bioinformatics (2004) 20(18): 3620-7.
N. Grabe. AliBaba2: context specific identification of transcription factor binding sites, In
Silico Biol. 2002;2(1):S1-15.
EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
• Supervision of several diploma thesis, International reviewer of doctoral theses,
• Currently supervising 3 doctoral thesis