Prof. Dr. Christine Clayton Center for Molecular Biology ... - HBIGS

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PUBLICATIONS (10 most important publications): Li CH, Irmer H, Gudjonsdottir-Planck D, Freese S, Salm H, Haile S, Estévez A, Clayton CE (2006) Role of a Trypanosoma brucei 5'->3' exoribonuclease homologue in mRNA degradation. RNA 12: 2171-2186. Haile S, Estévez AM, Clayton C (2003) A role for the exosome in the initiation of degradation of unstable mRNAs. RNA 9: 1491-1501. Estévez AM, Lehner B, Sanderson CM, Ruppert T, Clayton C (2003) The roles of intersubunit interactions in exosome stability. J Biol Chem 278: 34943-34951. Guerra-Giraldez C, Quijada L, Clayton, CE (2002) Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei J Cell Sci 115: 2651-2658. Shah, S, Krauth-Siegel L, Clayton CE (2002) Overproduction of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei. Mol Microbiol 43: 1129-1138. Estevez A, Kempf T, Clayton CE (2001) The exosome of Trypanosoma brucei. EMBO J 14: 3831-3839. Maier A, Lorenz P, Clayton CE (2001) A essential dimeric membrane protein of trypanosome glycosomes. Mol Microbiol 39: 1443-1451. Lorenz P, Meier A, Erdmann R, Baumgart E, Clayton CE (1998) Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p. EMBO J 17: 3542-3555. Krieger S, Schwarz,W, Ariyanagam MR, Fairlamb A, Krauth-Siegel L, Clayton CE (2000) Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Mol Microbiol 35: 542-552. Wirtz LE, Clayton CE (1995) Inducible gene expression in trypanosomes mediated by a prokaryotic repressor. Science 268: 1179-1183.
EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES Member of numerous thesis and thesis advisory committees International reviewer of doctoral theses Supervised 17 doctoral theses SUPERVISED DISSERTATIONS (last 5 years) Stefanie Brems, PhD (2006) Entwicklung eines DNA-Arrays zur Analyse der differentiellen Genexpression in Trypanosoma brucei. University of Heidelberg. Current occupation: travelling, subsequently post-doctoral fellow, DKFZ. Van-Duc Luu, PhD (2006) The Puf proteins in Trypanosoma brucei. University of Heidelberg. Current occupation: Postdoctoral fellow, DKFZ. Simon Haile, PhD (2004) Aspects of pre-mRNA processing and exosome-mediated mRNA degradation in tryanosomes. University of Heidelberg. Current occupation: Postdoctoral fellow, Canada. Pius Alibu, PhD (2004). Metabolite and drug transporters of Trypanosoma brucei. University of Heidelberg. Current occupation: Postdoctoral fellow, University of Glasgow. Cristina Guerra, Giraldez, PhD (2002) The role of the glycosomal protein PEX2 in bloodstream and procyclic forms of Trypanosoma brucei. University of Heidelberg. Current occupation: Laboratory head, LIma, Peru. Lilian Storm, MD (2006) Ein doppelt induzierbares System für die RNA-interferenz in Trypanosoma brucei. University of Heidelberg. Current occupation: Clinical practice and research, University of Heidelberg hospital.
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Prof. Dr. Christine Clayton Center for Molecular Biology ... - HBIGS

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