Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ... Dichlorvos (DDVP) Risk Characterization Document - California ...
Rutgers University, 1981. Petition proposing a tolerance for residues of dichlorvos (2,2-dichlorovinyl dimethyl phosphate) in or on figs. DPR Vol 235-004. S.C. Johnson & Son, Inc., 1980. Raid indoor fogger formula 5066D63-2. DPR Vol. 235-037. Schaible, S.A. (USEPA), 1994. Acute and chronic dietary exposure analyses for DDVP. Memorandum to D. Utterback and M. Beringer. December 2, 1994. Schaible, S.A. (USEPA), 1995. Addendum to DDVP chronic exposure analyses and cancer risk assessments evaluating dietary risk for the DDVP PD 2/3. Memorandum to Dennis Utterback. March 6, 1995. Schwetz, B.A., H.D. Ioset, B.K.J. Leong, and R.E. Staples, 1979a. Teratogenic potential of dichlorvos given by inhalation and gavage to mice and rabbits. Teratology 20:383-388. (in DPR Vol. 235- 072 #35433). Schwetz, B.A., H.D. Ioset, B.K.J. Leong, and R.E. Staples, 1979b. Teratogenic potential of dichlorvos given by inhalation and gavage to mice and rabbits. Teratology 20:383-388. (in DPR Vol. 235- 072 #35432). SDS Biotech Corporation, 1985. A micronucleus test in the mouse using dichlorvos. Document number: 695-5TX-83-0095-000. DPR Vol. 235-080 #37220. Segerback, D., 1981. Estimation of genetic risks of alkylating agents, V. Methylation of DNA in the mouse by DDVP (2,2-dichlorovinyl dimethyl phosphate). Hereditas 94:73-76. Selby, P.B., T.W. McKinley, and G.D. Raymer, 1982. Test of dichlorvos using the sensitive-indicator method for dominant skeletal mutations in mice. Environmental mutagenesis meeting abstract page 115 (in DPR Vol. 235-075 #35446). Shell Chemical Co., 1965. Evaluation of safety in using 20% Vapona insecticide resin strips. DPR Vol. 235-022. Shell Chemical Co., 1968. A petition proposing the establishment of a tolerance for the pesticide chemical Vapona (R) insecticide. DPR Vol. 235-033. Shell Chemical Co., 1971. Oral neurotoxic potential of technical dichlorvos (SD 1750) in the chicken. DPR Vol. 235-074 #35436. Slagowski, J.L. (Bio-Research Laboratories), 1987. Addendum to lifetime study in rats with Chevron naled technical - Dosage formulation analyses. Chevron Chemical Company. DPR Vol. 215- 097 #064701. Slomka, M.B. and C.H. Hine, 1981. Clinical pharmacology of dichlorvos. Acta Pharmacol. et Toxicol. 49, suppl. V: 105-108. Springborn Institute for Bioresearch, Inc., 1987. Acute oral toxicity study in rats LD50 study. Study no. 3168.3. AT&T Bell Laboratories. DPR Vol. 235-069 #75574 (same as 235-107 #95415). State of California, 1992. Consent judgment No. BC017081. June 9, 1992. Filed in the Superior Court of the State of California, Los Angeles County, Los Angeles, California. Stefanski, S.A., M.R. Elwell, and P.C. Stromberg, 1990. Chapter 22. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat (Boorman, G.A., M.R. Elwell, C.A. Montgomery, and W.F. MacKenzie, eds.), pp. 369-393. Academic Press, Inc., San Diego, CA. 89
TAS, 1992a. Exposure 4 . Detailed Distributional Dietary Exposure Analysis, Version 3.1. Technical Assessment Systems, Inc., Washington, D.C. TAS, 1992b. Exposure 1 . Chronic Dietary Exposure Analysis Version 3.1. Technical Assessment Systems, Inc., Washington D.C. The Hine Lab., 1962. 90-day chronic toxicity studies of Vapona insecticide for dogs. Shell Chemical Company. DPR Vol. 235-070 #35421. The Hine Lab., 1973a. Acute toxicity of Vapona ready-to-use. DPR Vol. 235-028 #911137. The Hine Lab., 1973b. Acute toxicity of Vapona ready-to-use. DPR Vol. 235-028 #911162. The Kettering Lab., 1964. Neurological effects (demyelination) of VAPONA insecticide on chickens. Shell Chemical Co., DPR Vol. 235-074 #35435. The Merck Index, 1989. Eleventh edition. (Budavari, S., M.J. O'Neil, A. Smith, and P.E. Heckelman, eds), Merck & Co., Inc. Rahway, NJ. 1606 pp. Thorpe, E., A.B. Wilson, K.M. Dix, and D.B. Blair (Tunstall Laboratory), 1971a. Toxicity studies with dichlorvos: teratogenic studies in rats and rabbits given dichlorvos by inhalation. DPR Vol. 235-072 #35428. Thorpe, E., A.B. Wilson, K.M. Dix, and D.B. Blair (Tunstall Laboratory), 1971b. Toxicity studies with dichlorvos: teratogenic studies in rats and rabbits given dichlorvos by inhalation. DPR Vol. 235-072 #35427. Tracy, R.L., J. G. Woodcock, and S. Chodroff, 1960. Toxicological aspects of 2,2-dichlorovinyl dimethyl phosphate (DDVP) in cows, horses, and white rats. J. Econ. Entomol. 53(4):593-601 (in DPR Vol. 235-042 #911129). Travis, C.C. and R.K. White, 1988. Interspecific scaling of toxicity data. Risk Anal. 8(1):119-125. Tyl, R.W. (Research Triangle Institute), 1990. Draft results of DDVP range-finding two-generation study. Amvac Chemical Company. DPR Vol. 235-105 #88543. Tyl, R.W., M.C. Marr, and C. B. Myers (Research Triangle Institute), 1991a. Developmental toxicity evaluation of DDVP administered by gavage to CD (Sprague-Dawley) rats. Amvac Chemical Company. DPR Vol. 235-110 #96391. Tyl, R.W., M.C. Marr, and C. B. Myers (Research Triangle Institute), 1991b. Developmental toxicity evaluation of DDVP administered by gavage to New Zealand White rabbits. Amvac Chemical Company. DPR Vol. 235-111 #96392. Tyl, R.W., C.B. Myers, and M.C. Marr (Research Triangle Institute), 1992. Two-generation reproductive toxicity study of DDVP administered in the drinking water to CD (Sprague- Dawley) rats. Amvac Chemical Company. DPR Vol. 235-118 #117629. USDA, 1987-1988. Data set: NFCS 87-I-1 Nationwide Food Consumption Survey. 1987-1988. Preliminary report unpublished. U.S. Department of Agriculture, Washington, D.C. USEPA, 1982. Pesticide Assessment Guidelines Subdivision O- Residue Chemistry. Office of Pesticides and Toxic Substances document # EPA-540/9-82-023. USEPA, 1987. EPA Guidance for the Reregistration of Pesticide Products Containing DDVP as the Active Ingredient. Office of Pesticides and Toxic Substances, Washington, DC. 90
- Page 45 and 46: Capsules - Dog DDVP (97.3-99.5% pur
- Page 47 and 48: Table 9. The no-observed-effect lev
- Page 49 and 50: Mice exposed to DDVP by inhalation
- Page 51 and 52: F. REPRODUCTIVE TOXICITY Summary: E
- Page 53 and 54: Table 11. The dosages and the inhib
- Page 55 and 56: G. DEVELOPMENTAL TOXICITY Summary:
- Page 57 and 58: levels not verified, too few pregna
- Page 59 and 60: H. NEUROTOXICITY Summary: Possible
- Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
- Page 63 and 64: Acute Toxicity Inhalation The criti
- Page 65 and 66: ates were not statistically signifi
- Page 67 and 68: In mice, there were dose-related in
- Page 69 and 70: B. EXPOSURE ASSESSMENT The exposure
- Page 71 and 72: The U.S. Department of Agriculture
- Page 73 and 74: Acute Exposure Estimates of potenti
- Page 75 and 76: Table 19. Commodity contribution of
- Page 77 and 78: C. RISK CHARACTERIZATION The potent
- Page 79 and 80: Table 23. The margins of safety for
- Page 81 and 82: Table 25. The margins of safety of
- Page 83 and 84: label between treatment and the ava
- Page 85 and 86: VI. TOLERANCE ASSESSMENT A. BACKGRO
- Page 87 and 88: VII. CONCLUSIONS The toxicological
- Page 89 and 90: Bomhard, E., and M. Rinke, 1994. Fr
- Page 91 and 92: DPR, 1992. Sampling for pesticide r
- Page 93 and 94: Horn, K.-H., B. Teichmann, and T. S
- Page 95: NTP (National Toxicology Program),
- Page 99 and 100: Warf Institute Inc., 1977c. Acute e
- Page 101 and 102: APPENDIX A U.S. ENVIRONMENTAL PROTE
- Page 103 and 104: APPENDIX B Department of Pesticide
- Page 105 and 106: TABLE 2: Percent DDVP Dermal Absorp
- Page 107 and 108: RESIDENT EXPOSURES Environmental mo
- Page 109 and 110: post-treatment, respectively. Glove
- Page 111 and 112: Ross, J.H., H.R. Fong, , T. Thongsi
- Page 113 and 114: APPENDIX C NALED TOXICOLOGY OF NALE
- Page 115 and 116: APPENDIX D CALCULATION EQUATIONS 1.
- Page 117 and 118: APPENDIX E ONCOGENICITY POTENCY CAL
- Page 119: APPENDIX E (continued) ONCOGENICITY
TAS, 1992a. Exposure 4 . Detailed Distributional Dietary Exposure Analysis, Version 3.1. Technical<br />
Assessment Systems, Inc., Washington, D.C.<br />
TAS, 1992b. Exposure 1 . Chronic Dietary Exposure Analysis Version 3.1. Technical Assessment<br />
Systems, Inc., Washington D.C.<br />
The Hine Lab., 1962. 90-day chronic toxicity studies of Vapona insecticide for dogs. Shell Chemical<br />
Company. DPR Vol. 235-070 #35421.<br />
The Hine Lab., 1973a. Acute toxicity of Vapona ready-to-use. DPR Vol. 235-028 #911137.<br />
The Hine Lab., 1973b. Acute toxicity of Vapona ready-to-use. DPR Vol. 235-028 #911162.<br />
The Kettering Lab., 1964. Neurological effects (demyelination) of VAPONA insecticide on chickens.<br />
Shell Chemical Co., DPR Vol. 235-074 #35435.<br />
The Merck Index, 1989. Eleventh edition. (Budavari, S., M.J. O'Neil, A. Smith, and P.E. Heckelman,<br />
eds), Merck & Co., Inc. Rahway, NJ. 1606 pp.<br />
Thorpe, E., A.B. Wilson, K.M. Dix, and D.B. Blair (Tunstall Laboratory), 1971a. Toxicity studies with<br />
dichlorvos: teratogenic studies in rats and rabbits given dichlorvos by inhalation. DPR Vol.<br />
235-072 #35428.<br />
Thorpe, E., A.B. Wilson, K.M. Dix, and D.B. Blair (Tunstall Laboratory), 1971b. Toxicity studies with<br />
dichlorvos: teratogenic studies in rats and rabbits given dichlorvos by inhalation. DPR Vol.<br />
235-072 #35427.<br />
Tracy, R.L., J. G. Woodcock, and S. Chodroff, 1960. Toxicological aspects of 2,2-dichlorovinyl<br />
dimethyl phosphate (<strong>DDVP</strong>) in cows, horses, and white rats. J. Econ. Entomol. 53(4):593-601<br />
(in DPR Vol. 235-042 #911129).<br />
Travis, C.C. and R.K. White, 1988. Interspecific scaling of toxicity data. <strong>Risk</strong> Anal. 8(1):119-125.<br />
Tyl, R.W. (Research Triangle Institute), 1990. Draft results of <strong>DDVP</strong> range-finding two-generation<br />
study. Amvac Chemical Company. DPR Vol. 235-105 #88543.<br />
Tyl, R.W., M.C. Marr, and C. B. Myers (Research Triangle Institute), 1991a. Developmental toxicity<br />
evaluation of <strong>DDVP</strong> administered by gavage to CD (Sprague-Dawley) rats. Amvac Chemical<br />
Company. DPR Vol. 235-110 #96391.<br />
Tyl, R.W., M.C. Marr, and C. B. Myers (Research Triangle Institute), 1991b. Developmental toxicity<br />
evaluation of <strong>DDVP</strong> administered by gavage to New Zealand White rabbits. Amvac Chemical<br />
Company. DPR Vol. 235-111 #96392.<br />
Tyl, R.W., C.B. Myers, and M.C. Marr (Research Triangle Institute), 1992. Two-generation<br />
reproductive toxicity study of <strong>DDVP</strong> administered in the drinking water to CD (Sprague-<br />
Dawley) rats. Amvac Chemical Company. DPR Vol. 235-118 #117629.<br />
USDA, 1987-1988. Data set: NFCS 87-I-1 Nationwide Food Consumption Survey. 1987-1988.<br />
Preliminary report unpublished. U.S. Department of Agriculture, Washington, D.C.<br />
USEPA, 1982. Pesticide Assessment Guidelines Subdivision O- Residue Chemistry. Office of<br />
Pesticides and Toxic Substances document # EPA-540/9-82-023.<br />
USEPA, 1987. EPA Guidance for the Reregistration of Pesticide Products Containing <strong>DDVP</strong> as the<br />
Active Ingredient. Office of Pesticides and Toxic Substances, Washington, DC.<br />
90
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