Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ... Dichlorvos (DDVP) Risk Characterization Document - California ...
Lamb, I.C. (WIL Research Lab., Inc.), 1993a. An acute neurotoxicity study of dichlorvos in rats. Amvac Chemical Corp. DPR Vol. 235-124 #120984. Lamb, I.C. (WIL Research Lab., Inc.), 1993b. A subchronic (13 week) neurotoxicity study of dichlorvos in rats. Amvac Chemical Corp. DPR Vol. 235-133 #126465. Leafe, T.D. and W.A. Feiler, 1988. Stability of DDVP in drinking water. EPA MRID 407440-02, DPR vol 235-081 #69615. Loeffler, J.E., J.C. Potter, S.L. Scordelis, H.R. Hendrickson, C.K. Huston, and A.C. Page, 1976. Longterm exposure of swine to a 14 C-dichlorvos atmosphere. J. Agric. Food Chem. 24:367-371. March, K.L., P.A. Noland, L.L. Roesel, and D.M. Chickering (ABC Laboratories, Inc.), 1993. Magnitude of the residue of dichlorvos in milk and dairy cow tissues. DPR Vol. 235-136 #127249. Markiewicz, V.R. (Hazleton Laboratories America, Inc.), 1990. A 52-week chronic toxicity study on DDVP in dogs. Amvac Chemical Corp. Study No. 2534-102. DPR Vol. 235-106 #88784. McConnell, E.E., H.A. Solleveld, J.A. Swenberg, and G.A. Boorman, 1986. Guidelines for combing neoplasms for evaluation of rodent carcinogenesis studies. J. Natl. Cancer Inst. 76(2):283- 289. McKnight, B., 1991. Chapter 22. Survival analysis. In Statistics in Toxicology (ed. D. Krewski and C. Franklin). Gordon and Breach Science Publishers, New York. pp. 471-498. Mendoza, C.E., 1976. Toxicity and effects of malathion on esterases of suckling albino rats. Toxicol. Appl. Pharmacol. 35:229-238. Mehler, L., 1993. California Pesticide Illness Surveillance Program in which health effects were attributed to exposure to DDVP. Worker Health and Safety Branch, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, California. Mennear, J.H. (Campbell University), 1988. Mononuclear cell leukemia and pancreatic acinar-cell neoplasia in male F 344/N rats: a review of NTP study interpretations. Amvac Chemical Corp. DPR Vol. 235-081 #69617. Mennear, J.H. (Campbell University), 1989. Dichlorvos risk assessment pursuant to the birth defects prevention act. Amvac Chemical Corp. DPR Vol. 235-098 #85288. Menz, M., H. Luetkemeier, and K. Sachsse, 1974. Long-term exposure of factory workers. Arch. Environ. Health 28:72-76. Microbiological Associates, Inc., 1985. In vivo sister chromatid exchange assay in mice with T-169-1. SDS Biotech Corp. Study No. 695-5TX-85-0003-000. DPR Vol. 235-080 #37223. Murphy, S., 1986. Toxic Effects of Pesticides. In: Casarett and Doull's Toxicology, The Basic Science of Poisons, 3rd Edition (Klaassen, C. D. , M. O. Amdur and J. Doull, Eds.), pp. 519-581. MacMillan Publishing Co., Inc., New York. 974 pp. NCI (National Cancer Institute), 1977a. Bioassay of dichlorvos for possible carcinogenicity (rat). Study No. NCI-CG-TR-10. DPR Vol. 235-071 #35425. NCI (National Cancer Institute), 1977b. Bioassay of dichlorvos for possible carcinogenicity (mouse). Study No. NCI-CG-TR-10. DPR Vol. 235-071 #35426. 87
NTP (National Toxicology Program), 1985. A synopsis of a mouse lymphoma forward mutation assay with dichlorvos. SDS Biotech Corp. Report No. 695-5TX-85-0065-001. DPR Vol. 235-080 #37219. Page, A.C., J.E. Loeffler, H.R. Hendrickson, C.K. Huston, and D.M. DeVries, 1971. Metabolic fate of dichlorvos in swine. Arch. Toxikol. 30:19-27. Pena Chavarria, A., J.C. Swartzwelder, V.M. Villarejos, E. Kotcher, and J. Arguedas, 1969. Dichlorvos, an effective broad-spectrum anthelmintic. Am. J. Tropical Med. and Hygiene 18(6):907-911. Pet Chemicals, Inc., 1983. Pest control products Vapona total release aerosol. DPR Vol. 235-047. Pharmakon Research International, Inc., 1984. Primary dermal irritation study in rabbits. Study no. PH 420-BL-004-84. AT&T Bell Laboratories. DPR Vol. 235-069 #75569 (same as DPR Vol. 235-107 #95410). Pharmakon Research International, Inc., 1985. Acute dermal toxicity test in rabbits. Study no. PH 422-BL-003-84. AT&T Bell Laboratories. DPR Vol. 235-069 #75571 (same as DPR Vol. 235- 107 #95412). Pharmakon Research International, Inc., 1987. Acute exposure oral toxicity study in rats. PH 402-BL- 001-86. AT&T Bell Laboratories. DPR Vol. 235-069 #75573. Pharmakon Research International, Inc., 1989. Primary eye irritation test. Study no. PH 421-BL-005- 84. AT&T Bell Laboratories. DPR Vol. 235-069 #75570 (same as DPR Vol. 235-107 #95411). Potter, J.C., A.C. Boyer, R.E. Marxmiller, R. Young, and J.E. Loeffler, 1973a. Radioisotope residues and residues of dichlorvos and its metabolites in pregnant sows and their progeny dosed with dichlorvos- 14 C or dichlorvos- 36 Cl formulated as PVC pellets. J. Agric. Food Chem. 21:734-738. Potter, J.C., J.E. Loeffler, R.D. Collins, R. Young, and A.C. Page, 1973b. Carbon-14 balance and residues of dichlorvos and its metabolites in pigs dosed with dichlorvos- 14 C. J. Agric. Food Chem. 21:163-166. Product Safety Lab., 1982a. Data to support registration of Prentox DDVP five to add additional pests and change precautionary language. Prentiss Drug & Chemical Co. DPR Vol. 235-043 #911199. Product Safety Lab., 1982b. Data to support registration of Prentox DDVP five to add additional pests and change precautionary language. Prentiss Drug & Chemical Co. DPR Vol. 235-043 #911211. Putman, D. (Microbiological Associates, Inc.), 1985. A dominant lethal assay in mice with T-169-1. SDS Biotech Protocol 695-5TX-85-0004-000. DPR Vol. 235-080 #37225. Putman, D.L. and E.H. Shadley (Microbiological Associates, Inc.), 1992. In vivo cytogenetics assay: Analysis of chromosomal aberrations in bone marrow and spermatogonial cells following repeated dose administration. Amvac Chemical Corp. DPR Vol. 235-123 #120415. Rasmussen, W.A., J.A. Jensen, W.J. Stein, and W.J. Hayes, 1963. Toxicological studies of DDVP for disinsection of aircraft. Aerospace Medicine 34:593-600. Roy, R.R. (Center for Food Safety and Applied Nutrition), 1991. Domestic food and feed samples for FY 85 to FY 90 analyzed for dichlorvos. Food and Drug Administration, Department of Health & Human Services. 88
- Page 43 and 44: Gavage - Mouse In a study conducted
- Page 45 and 46: Capsules - Dog DDVP (97.3-99.5% pur
- Page 47 and 48: Table 9. The no-observed-effect lev
- Page 49 and 50: Mice exposed to DDVP by inhalation
- Page 51 and 52: F. REPRODUCTIVE TOXICITY Summary: E
- Page 53 and 54: Table 11. The dosages and the inhib
- Page 55 and 56: G. DEVELOPMENTAL TOXICITY Summary:
- Page 57 and 58: levels not verified, too few pregna
- Page 59 and 60: H. NEUROTOXICITY Summary: Possible
- Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
- Page 63 and 64: Acute Toxicity Inhalation The criti
- Page 65 and 66: ates were not statistically signifi
- Page 67 and 68: In mice, there were dose-related in
- Page 69 and 70: B. EXPOSURE ASSESSMENT The exposure
- Page 71 and 72: The U.S. Department of Agriculture
- Page 73 and 74: Acute Exposure Estimates of potenti
- Page 75 and 76: Table 19. Commodity contribution of
- Page 77 and 78: C. RISK CHARACTERIZATION The potent
- Page 79 and 80: Table 23. The margins of safety for
- Page 81 and 82: Table 25. The margins of safety of
- Page 83 and 84: label between treatment and the ava
- Page 85 and 86: VI. TOLERANCE ASSESSMENT A. BACKGRO
- Page 87 and 88: VII. CONCLUSIONS The toxicological
- Page 89 and 90: Bomhard, E., and M. Rinke, 1994. Fr
- Page 91 and 92: DPR, 1992. Sampling for pesticide r
- Page 93: Horn, K.-H., B. Teichmann, and T. S
- Page 97 and 98: TAS, 1992a. Exposure 4 . Detailed
- Page 99 and 100: Warf Institute Inc., 1977c. Acute e
- Page 101 and 102: APPENDIX A U.S. ENVIRONMENTAL PROTE
- Page 103 and 104: APPENDIX B Department of Pesticide
- Page 105 and 106: TABLE 2: Percent DDVP Dermal Absorp
- Page 107 and 108: RESIDENT EXPOSURES Environmental mo
- Page 109 and 110: post-treatment, respectively. Glove
- Page 111 and 112: Ross, J.H., H.R. Fong, , T. Thongsi
- Page 113 and 114: APPENDIX C NALED TOXICOLOGY OF NALE
- Page 115 and 116: APPENDIX D CALCULATION EQUATIONS 1.
- Page 117 and 118: APPENDIX E ONCOGENICITY POTENCY CAL
- Page 119: APPENDIX E (continued) ONCOGENICITY
Lamb, I.C. (WIL Research Lab., Inc.), 1993a. An acute neurotoxicity study of dichlorvos in rats.<br />
Amvac Chemical Corp. DPR Vol. 235-124 #120984.<br />
Lamb, I.C. (WIL Research Lab., Inc.), 1993b. A subchronic (13 week) neurotoxicity study of<br />
dichlorvos in rats. Amvac Chemical Corp. DPR Vol. 235-133 #126465.<br />
Leafe, T.D. and W.A. Feiler, 1988. Stability of <strong>DDVP</strong> in drinking water. EPA MRID 407440-02, DPR<br />
vol 235-081 #69615.<br />
Loeffler, J.E., J.C. Potter, S.L. Scordelis, H.R. Hendrickson, C.K. Huston, and A.C. Page, 1976. Longterm<br />
exposure of swine to a 14 C-dichlorvos atmosphere. J. Agric. Food Chem. 24:367-371.<br />
March, K.L., P.A. Noland, L.L. Roesel, and D.M. Chickering (ABC Laboratories, Inc.), 1993.<br />
Magnitude of the residue of dichlorvos in milk and dairy cow tissues. DPR Vol. 235-136<br />
#127249.<br />
Markiewicz, V.R. (Hazleton Laboratories America, Inc.), 1990. A 52-week chronic toxicity study on<br />
<strong>DDVP</strong> in dogs. Amvac Chemical Corp. Study No. 2534-102. DPR Vol. 235-106 #88784.<br />
McConnell, E.E., H.A. Solleveld, J.A. Swenberg, and G.A. Boorman, 1986. Guidelines for combing<br />
neoplasms for evaluation of rodent carcinogenesis studies. J. Natl. Cancer Inst. 76(2):283-<br />
289.<br />
McKnight, B., 1991. Chapter 22. Survival analysis. In Statistics in Toxicology (ed. D. Krewski and C.<br />
Franklin). Gordon and Breach Science Publishers, New York. pp. 471-498.<br />
Mendoza, C.E., 1976. Toxicity and effects of malathion on esterases of suckling albino rats. Toxicol.<br />
Appl. Pharmacol. 35:229-238.<br />
Mehler, L., 1993. <strong>California</strong> Pesticide Illness Surveillance Program in which health effects were<br />
attributed to exposure to <strong>DDVP</strong>. Worker Health and Safety Branch, Department of Pesticide<br />
Regulation, <strong>California</strong> Environmental Protection Agency, Sacramento, <strong>California</strong>.<br />
Mennear, J.H. (Campbell University), 1988. Mononuclear cell leukemia and pancreatic acinar-cell<br />
neoplasia in male F 344/N rats: a review of NTP study interpretations. Amvac Chemical Corp.<br />
DPR Vol. 235-081 #69617.<br />
Mennear, J.H. (Campbell University), 1989. <strong>Dichlorvos</strong> risk assessment pursuant to the birth defects<br />
prevention act. Amvac Chemical Corp. DPR Vol. 235-098 #85288.<br />
Menz, M., H. Luetkemeier, and K. Sachsse, 1974. Long-term exposure of factory workers. Arch.<br />
Environ. Health 28:72-76.<br />
Microbiological Associates, Inc., 1985. In vivo sister chromatid exchange assay in mice with T-169-1.<br />
SDS Biotech Corp. Study No. 695-5TX-85-0003-000. DPR Vol. 235-080 #37223.<br />
Murphy, S., 1986. Toxic Effects of Pesticides. In: Casarett and Doull's Toxicology, The Basic Science<br />
of Poisons, 3rd Edition (Klaassen, C. D. , M. O. Amdur and J. Doull, Eds.), pp. 519-581.<br />
MacMillan Publishing Co., Inc., New York. 974 pp.<br />
NCI (National Cancer Institute), 1977a. Bioassay of dichlorvos for possible carcinogenicity (rat).<br />
Study No. NCI-CG-TR-10. DPR Vol. 235-071 #35425.<br />
NCI (National Cancer Institute), 1977b. Bioassay of dichlorvos for possible carcinogenicity (mouse).<br />
Study No. NCI-CG-TR-10. DPR Vol. 235-071 #35426.<br />
87
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