Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ... Dichlorvos (DDVP) Risk Characterization Document - California ...
Table 24. The margins of safety of potential acute and chronic dietary exposures to DDVP. Population subgroups DPR DPR USEPA Acute exposure Chronic exposure Chronic exposure MOS a MOS b MOS b US Population all seasons 550 223 1389 Western Region 568 233 1316 Hispanics 497 213 1316 Non-Hispanic Whites 577 232 1389 Non-Hispanic Blacks 481 190 1613 Non-Hispanic Other 441 178 1429 Infants (nursing) 802 861 2632 Infants (non-nursing) 348 205 794 Children (1-6 yrs) 303 95 658 Children (7-12 yrs) 435 142 943 Females (13-19 yrs) 778 254 1667 (not pregnant, not nursing) Females (13+ yrs) 975 298 1852 (pregnant, not nursing) Females (13+ yrs) 957 274 1471 (nursing) Females (20+ yrs) 993 315 1923 (not pregnant, not nursing) Males (13-19 yrs) 724 209 1389 Males (20+ yrs) 881 273 1724 Seniors (55+ yrs) 1027 NA c NA c a/ MOS = NOEL (500 ug/kg-day) Exposure Dosage based on cholinergic signs observed in rat oral studies (Lamb, 1992 and Lamb, 1993a). b/ MOS = NOEL (50 ug/kg-day) Exposure Dosage based on brain ChE inhibition and cholinergic signs in a dog oral study (Markiewicz, 1990). c/ Chronic exposure data for this age group alone are not available. 73
Table 25. The margins of safety of potential acute, chronic, and lifetime combined occupational, residential, and dietary exposures to DDVP a . Acute Exposure Chronic Exposure Lifetime Exposure Exposure type MOS b MOS c MOS c Risk d Occupational, home, and diet Warehouse worker 4 12 20 2 x 10 -4 - 4 x 10 -4 Structural Pest Control Operator 4 11 19 3 x 10 -4 - 5 x 10 -4 Livestock applicator 2 4 7 7 x 10 -4 - 1 x 10 -3 a/ b/ Total exposure levels were from Tables 20 (acute exposure) and 21 (chronic and lifetime exposures). MOS= NOEL (325 ug/kg-day) Total Exposure based on death in a rabbit inhalation study (Thorpe et al., 1971b). c/ MOS= NOEL (25 ug/kg-day) Total Exposure based on brain ChE inhibition in a rat inhalation study (Blair et al., 1974). d/ Range for risk was calculated using the q 1 of 0.20 and q 1 * of 0.35 (mg/kg-day -1 ) for mononuclear leukemia in a rat gavage study (Chan, 1989) and the equation of risk = potency x total exposure. 74
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- Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
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Table 24.<br />
The margins of safety of potential acute and chronic dietary exposures to <strong>DDVP</strong>.<br />
Population subgroups<br />
DPR DPR USEPA<br />
Acute exposure Chronic exposure Chronic exposure<br />
MOS a MOS b MOS b<br />
US Population all seasons 550 223 1389<br />
Western Region 568 233 1316<br />
Hispanics 497 213 1316<br />
Non-Hispanic Whites 577 232 1389<br />
Non-Hispanic Blacks 481 190 1613<br />
Non-Hispanic Other 441 178 1429<br />
Infants (nursing) 802 861 2632<br />
Infants (non-nursing) 348 205 794<br />
Children (1-6 yrs) 303 95 658<br />
Children (7-12 yrs) 435 142 943<br />
Females (13-19 yrs) 778 254 1667<br />
(not pregnant, not nursing)<br />
Females (13+ yrs) 975 298 1852<br />
(pregnant, not nursing)<br />
Females (13+ yrs) 957 274 1471<br />
(nursing)<br />
Females (20+ yrs) 993 315 1923<br />
(not pregnant, not nursing)<br />
Males (13-19 yrs) 724 209 1389<br />
Males (20+ yrs) 881 273 1724<br />
Seniors (55+ yrs) 1027 NA c NA c<br />
a/<br />
MOS = NOEL (500 ug/kg-day)<br />
Exposure Dosage<br />
based on cholinergic signs observed in rat oral studies (Lamb, 1992 and Lamb, 1993a).<br />
b/<br />
MOS = NOEL (50 ug/kg-day)<br />
Exposure Dosage<br />
based on brain ChE inhibition and cholinergic signs in a dog oral study (Markiewicz, 1990).<br />
c/<br />
Chronic exposure data for this age group alone are not available.<br />
73
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