Dichlorvos (DDVP) Risk Characterization Document - California ...

CONCLUSIONS
The toxicological risk of potential exposure to DDVP was evaluated for occupational, residential,
dietary and combined uses based on the inhibition of brain ChE activity, clinical signs, and the finding
of mononuclear leukemia in animal studies. Using the conventional benchmark levels, a margin of
safety of at least 100 for non-oncogenic effects and a risk level of 1 x 10 -6 or less for oncogenic effects
are generally considered sufficiently protective of human health. The exposure levels of only a few
groups meet those benchmark levels. Groups which have exposure levels which do not meet the
benchmark levels are: all people occupationally exposed to DDVP alone and in combination with
home exposure on an acute, chronic, and lifetime basis; people exposed through residential use on
an acute, chronic, and lifetime basis; and the general population exposed through the diet on a
potentially lifetime basis.
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