Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ... Dichlorvos (DDVP) Risk Characterization Document - California ...
B6C3F1 mice were fed DDVP (94% purity) daily in the diet at 1000 and 2000 ppm for 2 weeks, and 300 and 600 ppm, respectively, from weeks 3 to 80 because of toxicity (tremors, rough coat, and diarrhea) with the initial doses (NCI, 1977b). The NOEL for cholinergic signs in 2 weeks was 1000 ppm (150 mg/kg-day). 29
Table 3. Selected no-observed-effect levels (NOELs) and lowest-observed-effect levels (LOELs) of DDVP from subchronic studies. Plasma ChE a RBC ChE a Brain ChE a Other Effects Species Route Duration a NOEL LOEL % C NOEL LOEL % C NOEL LOEL % C NOEL LOEL Effects Ref. b (mg/kg-day) (mg/kg-day) (mg/kg-day) (mg/kg-day) Rat gavage 5d/wx13w 1.1 10.7 53-65% 0.1 1.1 75% (M) a 1.1 10.7 50% 1.1 10.7 salivation, urine stain 1 at 14w 50 no effects 3 Rat c diet 7d/wx3w - - - - - - 15 50 tremors, diarrhea 4 Rat d water daily 2.7 9.5 parental 5* -decreased fertility, females F0 1.1 4.6 45%
- Page 1 and 2: DICHLORVOS (DDVP) RISK CHARACTERIZA
- Page 3 and 4: transmitter of signals from the ner
- Page 5 and 6: Contributors and Acknowledgments Pr
- Page 7 and 8: List of Tables Pages 1. The acute t
- Page 9 and 10: hematocrit) in rats. From studies w
- Page 11 and 12: II. INTRODUCTION The human health r
- Page 13 and 14: food service facilities); hand-held
- Page 15 and 16: G. ENVIRONMENTAL FATE Summary: DDVP
- Page 17 and 18: III. TOXICOLOGY PROFILE Pharmacokin
- Page 19 and 20: Inhalation - Rat Carworth Farm stra
- Page 21 and 22: DIMETHYL PHOSPHATE Oral - Rat Rats
- Page 23 and 24: B. ACUTE TOXICITY Summary: The acut
- Page 25 and 26: Oral - Human One hundred and eight
- Page 27 and 28: Table 1. The acute toxicity of DDVP
- Page 29 and 30: Table 1. The acute toxicity of DDVP
- Page 31 and 32: Table 2. Selected no-observed-effec
- Page 33 and 34: dose-related manner. At a dosage of
- Page 35: pretreatment levels, respectively.
- Page 39 and 40: Gavage - Rat In a study conducted b
- Page 41 and 42: ate (Appendix D) and the assumption
- Page 43 and 44: Gavage - Mouse In a study conducted
- Page 45 and 46: Capsules - Dog DDVP (97.3-99.5% pur
- Page 47 and 48: Table 9. The no-observed-effect lev
- Page 49 and 50: Mice exposed to DDVP by inhalation
- Page 51 and 52: F. REPRODUCTIVE TOXICITY Summary: E
- Page 53 and 54: Table 11. The dosages and the inhib
- Page 55 and 56: G. DEVELOPMENTAL TOXICITY Summary:
- Page 57 and 58: levels not verified, too few pregna
- Page 59 and 60: H. NEUROTOXICITY Summary: Possible
- Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
- Page 63 and 64: Acute Toxicity Inhalation The criti
- Page 65 and 66: ates were not statistically signifi
- Page 67 and 68: In mice, there were dose-related in
- Page 69 and 70: B. EXPOSURE ASSESSMENT The exposure
- Page 71 and 72: The U.S. Department of Agriculture
- Page 73 and 74: Acute Exposure Estimates of potenti
- Page 75 and 76: Table 19. Commodity contribution of
- Page 77 and 78: C. RISK CHARACTERIZATION The potent
- Page 79 and 80: Table 23. The margins of safety for
- Page 81 and 82: Table 25. The margins of safety of
- Page 83 and 84: label between treatment and the ava
- Page 85 and 86: VI. TOLERANCE ASSESSMENT A. BACKGRO
Table 3.<br />
Selected no-observed-effect levels (NOELs) and lowest-observed-effect levels (LOELs) of <strong>DDVP</strong> from subchronic studies.<br />
Plasma ChE a RBC ChE a Brain ChE a Other Effects<br />
Species Route Duration a NOEL LOEL % C NOEL LOEL % C NOEL LOEL % C NOEL LOEL Effects Ref. b<br />
(mg/kg-day) (mg/kg-day) (mg/kg-day) (mg/kg-day)<br />
Rat gavage 5d/wx13w 1.1 10.7 53-65% 0.1 1.1 75% (M) a 1.1 10.7 50% 1.1 10.7 salivation, urine stain 1<br />
at 14w 50 no effects 3<br />
Rat c diet 7d/wx3w - - - - - - 15 50 tremors, diarrhea 4<br />
Rat d water daily 2.7 9.5 parental 5*<br />
-decreased fertility,<br />
females F0 1.1 4.6 45%
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